摘要：Photodynamic therapy(PDT)as a non-invasive anticancer modality has received increasing attention due to its advantages of noninvasiveness,high temporospatial selectivity,simple and controllable operation,*** mainly relies on the generation of toxic reactive oxygen species(ROS)by photosensitizers(PSs)under the light irradiation to cause cancer cell apoptosis and ***,solid tumors usually exhibit an inherent hypoxic microenvironment,which greatly limits the PDT efficacy of these high oxygen-dependent conventional type II ***,it is of great importance to design and develop efficient type I PSs that are less oxygen-dependent for the treatment of hypoxic ***,a new strategy for the preparation of efficient type I PSs by introducing the photoinduced electron transfer(PET)mechanism is ***-NO_(2) is obtained by introducing 4-nitrobenzyl to(Z)-2-(5-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)malononitrile(DR-OH)with aggregation-induced emission(AIE)*** AIE feature ensures their high ROS generation efficiency in aggregate,and the PET process leads to fluorescence quenching of DR-NO_(2) to promote triplet state formation,which also promotes intramolecular charge separation and electron transfer that is conducive for type I ROS particularly superoxide radicals *** addition,DR-NO_(2) nanoparticles are prepared by nanoprecipitation to possess nanoscaled sizes,high cancer cell uptake,and excellent type I ROS generation ability,which results in an excellent performance in PDT ablation of MCF-7 cancer *** PET strategy for the development of type I PSs possesses great potential for PDT applications against hypoxic tumors.

摘要：β-Glucuronidase(GUS)plays a key role in tumor initiation,metastasis,and progression,and thus,has been proposed as a promising cancer *** this study,we designed an enzyme-activatable near-infrared(NIR)fluorescent probe(DCM-βGlcA)for the rapid and accurate detection of GUS activity in vitro,in vivo and ex *** DCM-βGlcA was prepared by linking a glucuronic acid residue to dicyanomethylene-4 H-pyran(DCM).This probe exhibited significant light-up NIR fluorescent signals at 680 nm after reacting with GUS and the Stokes shift could reach 150 *** DCM-βGlcA showed a high sensitivity toward GUS and an excellent linear relationship at concentrations ranging between 0 and 4 U L^(-1)(R^(2)=0.9974)with the limit of detection as low as 0.19 U L^(-1).We used the DCM-βGlcA to identify GUS serum levels in both cancer patients and healthy individuals with a similar accuracy as that of an enzyme-linked immunosorbent assay(ELISA)while being easier and faster to ***,the DCM-βGlcA was used for tracking endogenous GUS in living cells,thereby discriminating GUSoverexpressed liver cancer from normal ***,the DCM-βGlcA was able to detect and image endogenous GUS in liver cancer tissue and tumor-bearing mouse *** findings demonstrate the potential of the DCM-βGlcA as a promising tool for detecting and monitoring GUS activity in preclinical applications.

摘要：目的 研究改良Smith-Peterson入路和Moore入路人工股骨头置换治疗高龄股骨颈骨折的疗效。方法 该研究采用前瞻性、随机对照设计，研究时间为2020年1月至2022年12月，入组人群为信阳市人民医院行人工股骨头置换的股骨颈骨折的高龄老年患者。按照患者的入院时间，随机分为两组，一组患者行Moore入路（n=51）为Moore组，一组患者行改良的Smith-Peterson入路（n=52）为Smith-Peterson组。对患者手术情况、疼痛情况、生活质量、Harris评分、术后并发症发生情况及髋关节假体髋臼外展角、前倾角情况进行评估。结果 Smith-Peterson组患者，伤口长度为（10.01±1.01） cm，手术用时为（61.22±11.38） min，出血量为（77.28±21.35） mL，患者术后卧床时间（1.25±0.42） d，留院时间为（9.01±1.76） d，与Moore组患者比较差异有统计学意义（P0.05）。结论 采用的改良Smith-Peterson入路，可以减轻股骨颈骨折患者术后的疼痛程度，加快髋关节功能的恢复，改善患者生活质量，减少住院时间，临床应用价值显著。

摘要：为满足地震观测系统对实时性、高精度以及网络化的要求,提出了基于光纤B ragg光栅传感器和ARM的嵌入式系统设计方案,阐述了可调光纤F-P滤波器的工作机理和特点,并介绍了基于FBG传感器和ARM的地震观测系统的硬件结构和软件设计。采用三星公司的S3C2440对经过可调谐F-P腔解调后的波长信息进行采集,并对得到的数据进行处理。实验结果表明,该系统在处理精度和实时性方面都能达到要求,性价比高,有一定实用价值。

摘要：采用准静态载荷标定的方式制作牵引拉杆载荷传感器,将其安装于某型高速动车组进行线路载荷测试,得到列车启动牵引、高低速直线运行、通过坡道及制动停车等典型工况下的载荷时间历程及载荷变化特点。在此基础上,编制不同速度等级下的牵引拉杆载荷谱,并依据线性累积损伤准则分析结构疲劳损伤分布及运行速度对疲劳损伤的影响规律。研究结果表明,与拖车牵引拉杆载荷相比,动车牵引拉杆载荷幅值变化受电机扭矩载荷的影响较大,尤其在列车启动、制动阶段,其趋势载荷变化明显;随着列车运行速度的增加,牵引拉杆载荷幅值不断增大,得到动车牵引拉杆载荷的振动主频与列车运行速度呈正比。定义相对疲劳损伤来表征每级载荷的疲劳损伤贡献程度,得到结构疲劳损伤与牵引拉杆载荷幅值的对应关系,获取列车运行速度对结构疲劳累积损伤的影响规律。动车牵引拉杆载荷在列车时速280 km/h时产生的结构疲劳累积损伤最小,而拖车牵引拉杆的疲劳累积损伤值随着运行速度的增大呈现增大的趋势。该研究结果对高速列车转向架结构的优化设计及相关理论研究具有一定的参考价值。

摘要：设计了两种横向和纵向喉道宽度比值(wh∶wz)分别为1.48∶1和1∶1的各向异性和各向同性多孔介质微流体芯片,以CO_(2)为气体,二甲基硅油为液体,采用可视化实验,系统地研究了升温条件下多孔介质结构对气泡生长和聚并规律的影响。结果表明,温度升高引起的传质生长是气泡突破喉道的动力。单个气泡在多孔介质内生长方向的选择依赖于喉道的门阙压力,气泡倾向于突破门阙压力小的喉道。随着温度的升高,气泡侵入和突破喉道速度加快。在各向异性多孔介质中,气泡倾向于在横向生长时与其他气泡发生聚并,而在各向同性多孔介质中,气泡更易发生纵向聚并。当多个气泡存在于各向异性多孔介质内时,气泡的初始分布会显著影响气泡间的生长和聚并过程;在各向同性多孔介质内时,影响则较小。各向异性多孔介质在实际工程应用过程中更易实现气泡流型调控。

摘要：为践行新工科工程实践创新理念,以传热传质学课程实验教学为切入点,研制了一套干燥过程传热传质实验教学综合平台。该平台包括强制对流换热实验和干燥过程传热传质实验两个模块。利用LabVIEW搭建了一个实时数据采集、显示、记录和控制系统,实现了实验过程中对温度、风速、干燥过程水分蒸发量等数据的实时测量、显示和读写,系统还可对风机转速和加热功率进行控制。该实验平台不仅可以加深学生对传热传质知识的理解,而且能引导他们掌握温度、流速和质量等参量的测试过程,鼓励自主设计实验方案,培养学生的实践动手能力和工程素养。