摘要：We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring *** unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.

摘要：Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effective trimerization or dimerization respectively under highly diluted conditions in one pot.