摘要：数字化口腔修复学一直是国际口腔学界的前沿热点。从结果上看,口腔医学技术专业代表的口腔修复体制作端近十年来引入日益完善的计算机辅助设计、数控加工、制作等已相对成熟;但在口腔修复临床端,除数字化口扫、面扫、虚拟美学分析、设计及下颌运动轨迹描记等分析设计阶段运用了部分数字化手段外,大部分操作尤其是不可逆操作还是以经验类比模型为基础,数字化应用远未成熟。临床端缺少对目标修复空间的三维几何分析、精准转移及校验,是目前制约数字化口腔修复学整体进步的瓶颈,究其根源就是还没有真正做到遵循立体几何与测量学来形成数字化修复所需的精密逻辑基础。本文将探讨口腔修复中的立体几何量概念及其在修复边缘区域的典型表征、测量方案等,并总结当前弱人工智能阶段下数字化口腔修复学的学科特点与对未来的展望。

摘要：近年来,半导体材料在光电转化、光热转化、电池储能等方面的优势展现出了广阔应用前景而迅速发展。随着研究的深入,界面形成机理、电子结构、电荷转移过程的构效关系成为设计新型半导体器件、新材料研究的热点,支持能源催化、界面功能构筑和芯片器件等重大领域的发展,因此准确测量半导体薄膜材料的能级结构非常重要。测量半导体薄膜材料全能级结构常用X射线光电子能谱(XPS)、紫外光电子能谱(UPS)以及反光电子能谱(IPES)三种表征方法,重点介绍了三种表征方法的研究对象、理论基础与测量原理、测量方法与能级结构识别的方法对半导体薄膜材料全能级结构的测量。最后通过实际案例进行了数据分析和讨论。三种表征技术具有互补性,可以从能量角度给出更有效的信息,这对半导体薄膜材料制备、杂质掺杂、功能和性能优化具有重要意义。

摘要：目的观察乳腺癌术后放疗患者照射区症状纵向变化，探讨放疗期间预测急性放射性皮炎的相关症状指标。方法本研究为前瞻性纵向研究设计，采用便利抽样法选取2022年5月至2022年12月于河北医科大学第四医院103例接受三维适形放射治疗的乳腺癌根治术后患者为研究对象，患者共放疗50 Gy/25次，每周观察照射区瘙痒、疼痛、肿胀、灼热、紧绷感5个症状，共6次。比较不同程度放射性皮炎相关症状的发生情况，计算发生２级及以上放射性皮炎的最佳症状个数，应用受试者工作特征曲线（ROC）评价其预测效果，应用二元Logistic 回归比较不同症状个数与放射性皮炎发生的风险。结果103例患者纳入研究，症状的严重程度总评分分别为0（0，0）、0（0，0）、0（0，1）、1（0，2）、2（1，3）、3（2，4），呈现逐渐上升趋势。从放疗20 Gy/10次至放疗结束，症状评分与基线差异具有统计学意义（P均<0.001）。从放疗30 Gy/15次至放疗结束，2级及以上皮炎组症状得分高于2级以下皮炎组（Z=2.12、2.81、4.08，P=0.034、0.005、0.001）。放疗50 Gy/25次结束时，瘙痒、疼痛、肿胀、紧绷、灼热的发生率分别为68.9%（71例）、68.9%（71例）、46.6%（48例）、36.9%（38例）、15.5%（16例）。放疗30 Gy/15次、40 Gy/20次时最佳的预测症状个数分别为2个、3个，ROC曲线下面积分别为0.632、0.666，敏感度分别为48.6%、43.2%，特异性分别为77.3%、81.8%（95%CI：0.517～0.746、0.558～0.775，P=0.027、0.005）。用最佳截断值将受试者分为低风险组和高风险组，二元Logistic回归显示，高风险组发生2级及以上放射性皮炎的风险是低风险组的3.39、3.58倍（OR=3.388，95%CI：1.400～8.197，P=0.007;OR=3.584，95%CI：1.430～8.985，P=0.006）。结论放射性皮炎的症状早期已出现，且随皮炎程度加重而增加，应密切观察患者照射野区域的症状，放疗30 Gy/15次症状个数≥2个、40 Gy/20次症状个数≥3个时2级及以上放射性皮炎的发生风险增加。

摘要：During perfusion culture,the growth of bone tissues in the scaffold was closely related to the locations of initial adhered cells and their *** this study,the fluid mechanical responses of Voronoi-lattice scaffolds and initial adhered cells on scaffolds were quantitatively *** fluid-structure interaction(FSI)model was verified by comparing with the results of Diamond scaffolds culture in the *** mechanical responses of Voronoi-lattice scaffolds and cells were analyzed by multiphase FSI *** equations were established by response surface method(RSM)to determine relationships between structural design factors of Voronoi-lattice scaffolds and fluid mechanical response parameters of scaffolds and *** results showed that the percentage of adhered cells and the locations of initial adhered cells obtained by multiphase FSI model of Diamond scaffolds had the same trend with that obtained by perfusion *** equations established based on RSM could well predict the fluid mechanical response parameters of Voronoi-scaffolds and *** multiphase FSI model closely related the densities of cells and the locations of adhered cells to bone tissue *** model could provide a certain theoretical basis for constructing and culturing engineered bone tissues in vitro perfusion.

摘要：Extreme water level is an important consideration when designing coastal protection structures. However, frequency analysis recommended by standard codes only considers the annual maximum water level, whereas water levels should actually be regarded as a combination of astronomical tide and storm surge. The two impacting factors are both random variables, and this paper discusses their dependency structures and proposes a new joint probability method to determine extreme design water levels. The lognormal, Gumbel, Weibull, Pearson type 3, traditional maximum entropy, and modified maximum entropy distributions are applied to fit univariate data of astronomical tides and storm surges separately, and the bivariate normal, Gumbel-Hougaard, Frank and Clayton copulas are then utilized to construct their joint probability distributions. To ensure that the new design method is suitable for use with typhoon data, the annual occurrence frequency of typhoon processes is considered and corresponding bivariate compound probability distributions are proposed. Based on maximum water level data obtained from Hengmen hydrological station in the Pearl River Basin, China, these probability models are applied to obtain designs for extreme water levels using the largest sum of the astronomical tide and storm surge obtained under fixed joint return periods. These design values provide an improved approach for determining the necessary height of coastal and offshore structures.

摘要：针对编织设备自动化水平提升需求,特别是携纱器的位置控制与旋转定位问题,设计了一种新型携纱器位置检测和旋转定位系统。系统通过集成方位信号和旋转定位系统,提高了编织工艺的精度和效率。结果表明,系统在多种操作条件下均表现出良好的稳定性和可靠性,适用于完成复杂编织任务。通过信号圈与高灵敏度传感器、旋转码盘的协同工作,系统可实时监控携纱器位置与旋转角度,确保编织过程连续稳定,可提升三维编织设备的自动化水平和编织精度。

摘要：片段一日外城市上空似乎是黄昏时分,镜头如飞翔一般掠过城市上空,近处桥梁顶端的星条旗迎风招展,波光粼粼,对岸的高楼大厦鳞次栉比.

摘要：Proteolysis targeting chimeras（PROTACs） are bispecific molecules containing a target protein binder and a ubiquitin ligase binder connected by a linker. Recently, some heterobifunctional small molecule bromodomain-containing protein 4（BRD4） degraders based on the concept of PROTACs were designed to induce the degradation of BRD4 protein. Herein, we synthesized a new class of PROTAC BRD4 degraders. One of the most promising compound 22f exhibited robust potency of BRD4 inhibition with IC50 value of （9.4±0.6） nmol/L. Furthermore, com- pound 22f potently inhibited cell proliferation in BRD4-sensitive cell lines RS4;11 with IC50 value of （27.6±1.6） nmol/L and capable of inducing degradation of BRD4 protein at 0.5-1.0 μmol/L in the RS4;11 cells. These data establish that compound 22f is a potent and efficacious BRD4 degrader.

摘要：对产品信息建模和推理技术的形式化方法进行了研究。将机械产品中存在的约束关系分为3类4种,在功能方法树中以边的形式进行了表示,建立了包含约束信息的功能方法树模型,在此基础上,利用多色集合理论的元素、统一颜色、个人颜色等概念以及多色图,建立了产品概念设计形式化结构模型;从功能分解和约束条件两方面进行了数学形式的描述、推理,给出了实现产品概念设计形式化推理的计算机算法流程;以隔振系统的概念设计为例,应用和验证了以上理论和方法。研究表明,基于多色集合理论建立的机械产品概念设计模型易于形式化描述和推理,方便计算机编程。

摘要：针对大型宽体客机环保和经济性等方面的需求,提出在传统高升力控制系统实现起降增升、增阻的基础上,增加巡航减阻功能,通过机翼变弯度控制实现飞机在长时间巡航过程中的气动效能最优。首先,基于系统工程正向设计的思想进行了需求分析,提出巡航减阻的功能要求。随后,围绕需求和功能开展了物理架构设计,并分析了架构的安全性,提出了“集中式”和“分布式”两种设计方案;对比两种方案的优缺点,并从工程实现角度给出了方案的选用建议。最后,开展巡航减阻控制律的设计并进行了计算与仿真分析。计算表明,巡航机翼变弯度设计可提高航程、减少燃油消耗,满足飞机提出的环保性和经济性要求。仿真结果表明,在自动驾驶接通时接入巡航减阻功能,飞机构型变化过程平稳,满足飞行品质要求。