摘要：AIM: To explore the effect of SDF-1α on the development of experimental corneal neovascularization (CRNV).METHODS: CRNV was induced by alkali injury in mice. The expression of SDF-1α and CXCR4 in burned corneas was examined by Flow Cytometry. Neutralizing anti-mouse SDF-1α antibody was locally administrated after alkali injury and the formation of CRNV 2 weeks after injury was assessed by Immunohistochemistry. The expression of VEGF and C-Kit in burned corneas was detected by ***: The number of CRNV peaks at 2 weeks after alkali injury. Compared to control group, SDF-1α neutralizing antibody treatment significantly decreased the number of CRNV. RT-PCR confirmed that SDF-1α neutralizing antibody treatment resulted in decreased intracorneal VEGF and C-Kit ***: SDF-1α neutralizing antibody treated mice exhibited impaired experimental CRNV through down regulated VEGF and C-Kit expression.

摘要：基于标准的GaAs赝配高电子迁移率晶体管（PHEMT）单片微波集成电路（MMIC）工艺设计并制备了一款宽带收发一体多功能电路芯片。该多功能芯片包含了功率放大器、低噪声放大器和收发开关。放大器采用电流复用拓扑结构实现了低功耗的目标。收发开关采用浮地结构避免了使用负电源。芯片在14~24 GHz工作频率的实测结果显示：接收支路噪声系数小于3.0 dB,增益大于18 dB,输入及输出电压驻波比（VSWR）均小于2.0,1 dB压缩点输出功率大于0 dBm,直流功耗为60 mW;发射支路增益大于21 dB,输入输出VSWR均小于1.8,1 dB压缩点输出功率大于10 dBm,直流功耗为180 mW。芯片尺寸为2 600μm×1 800μm。该多功能收发电路的在片测试结果和仿真结果一致,性能达到了设计要求。

摘要：In order to better evaluate the transport effect of nanoparticles through the nasal mucosa,an in vitro nasal cavity-mimic model was designed based on M *** differentiation of M cells was induced by co-culture of Calu-3 and Raji cells in invert *** ZO-1 protein staining and the transport of fluorescein sodium and dexamethasone showed that the inverted co-culture model formed a dense monolayer and possessed the transport *** differentiation of M cells was observed by upregulated expression of Sialyl Lewis A antigen(SLAA)and integrinβ1,and down-regulated activity of alkaline *** targeting M cells with iRGD peptide(cRGDKGPDC),the transport of nanoparticles *** vivo,the co-administration of iRGD could result in the increase of nanoparticles transported to the brain through the nasal cavity after intranasal *** the evaluation of immune effect in vivo,the nasal administration of OVA-PLGA/iRGD led to more release of IgG,IFN-γ,IL-2 and secretory IgA(sIgA)compared with OVA@PLGA ***,the study constructed in vitro M cell model,and proved the enhanced effect of targeting towards M cell with iRGD on improving nasal immunity.

摘要：针对不同放电倍率下电池包对液冷系统的温控需求,设计了单进双出并联流道,并提出四置液冷板的冷却方案,以压降和流量均匀性为目标对单进双出并联流道结构进行优化。结果表明采用单进双出并联流道结构冷却时,电池包模组间最大温差的差值不超过0.08℃,冷却效果均衡,电池间温度一致性高。采用四置液冷板冷却时,2.5 C放电倍率下,模组间放置冷板相较于电池包侧面放置冷板最高温度低1.27℃,最大温差低1.1℃。对流道结构优化后,各流道流量最大偏差从20%下降到2.4%,压降下降了30%。优化后流道结构与蛇形流道散热性能相比,最高温度降低了2.22℃,最大温差降低了1.12℃。