摘要：In search of novel neuroprotective agents with higher potency and lower h ERG liability, a series of novel Fenazinel derivatives were designed and synthesized, among which compounds 8m–o containing amide moiety exhibited good neuroprotective effects in vitro and in vivo. Especially, the representative compound 8o showed lower activity in a patch clamp h ERG K^＋ion channel screen and could be considered as a lead compound for further development. These findings provided an alternative approach to the development of drugs more potent than Fenazinel for the intervention of ischemic stroke.

摘要：Bending deformation behaviors of solution treated(ST),natural aged(NA)and T6tempered6063aluminum alloy sheetswere studied by three-point bending *** changes of bending force,interior angle,bending radius and sheet thickness in thefillet region were analyzed by experimental measurements and numerical *** results showed that the bendingcharacteristics were strongly dependent on the heat treatment *** T6alloy sheets were bent more sharply and localplastic deformation occurred severely in the fillet ***,the ST and NA alloy sheets exhibited relatively uniform bendingdeformation and large bending *** bending force of T6alloy was the highest,followed by the NA alloy and that of the STalloy was *** unloading,as compared with the ST and NA alloys,the springback of T6alloys was markedly *** time showed a positive sensitivity on the springback and non-uniform bending *** bending characteristics areattributed to the combined effects of yield strength,yield ratio and coefficient of neutral layer.

摘要：6061 aluminum alloy T-joints were welded by double-pulsed MIG welding process. Then, the post-weld heat treatment was performed on the welded T-joints. The weld microstructure under different aging temperature and time was investigated by transmission electron microscopy and scanning electron microscopy. The mechanical properties were examined by hardness test and tensile test. The results showed that the micro-hardness was sensitive to heat treatment temperature and time. Increasing temperature was beneficial to the shortening of peak aging time. There were a large number of dislocations and few precipitates in the welded joints. With the increase of post-weld heat treatment temperature and time, the density of dislocation decreased. Meanwhile, the strengthening phase precipitated and grew up gradually. When the post-weld heat treatment temperature increased up to 200℃, large Q' phases were observed. And they were responsible for the peak value of the micro-hardness in the welded joints.

摘要：布鲁斯博物馆是一家位于康涅狄格州格林威治的地区性文化机构,拥有多学科藏品和展览项目,将艺术、科学和自然历史融为一体。2014年,在一场全国性设计竞赛之后,布鲁斯博物馆踏上了振兴其园区的征程,以将该机构带入未来。竞赛结束后,设计团队领导了一项严格的初步规划研究,深入挖掘博物馆的需求,并为其作为社区资源的能力提供支持。

摘要：The interfacial heat transfer coefficient between hot profile surface and cooling water was determined by using inverse heat conduction model combined with end quenching experiment. Then, a Deform-3 D thermo-mechanical coupling model for simulating the on-line water quenching of extruded profile with unequal and large thicknesses was developed. The temperature field, residual stress field and distortion of profile during quenching were investigated systematically. The results show that heat transfer coefficient increases as water flow rate increases. The peak heat transfer coefficient with higher water flow rates appears at lower interface temperatures. The temperature distribution across the cross-section of profile during quenching is severe nonuniform and the maximum temperature difference is 300 ℃ at quenching time of 3.49 s. The temperature difference through the thickness of different parts of profile first increases sharply to a maximum value, and then gradually decreases. The temperature gradient increases obviously with the increase of thickness of parts. After quenching, there exist large residual stresses on the inner side of joints of profile and the two ends of part with thickness of 10 mm. The profile presents a twisting-type distortion across the cross-section under non-uniform cooling and the maximum twisting angle during quenching is 2.78°.

摘要：The flow stress behavior and microstructure development of Al-5Zn-2Mg （7005） aluminum alloy were studied by hot compression tests at deformation temperatures between 300-500 ＆#176;C and strain rates between 0.05-50 s-1. The deformed structures of the samples were observed by optical microscopy （OM）, transmission electron microscopy （TEM） and electron backscattering diffraction （EBSD） analysis. The calculated activation energy is 147 kJ/mol, which is very close to the activation energy for lattice self-diffusion in aluminum （142 kJ/mol）. Dynamic recovery is the dominant restoration mechanism during the deformation. At high strain rate of 50 s-1, temperature rise due to deformation heating leads to a significant flow softening. Microstructure observations indicated that the remaining softening after deformation heating correction at high strain rate and the softening observed at high temperature are associated with grain coarsening induced by grain boundary migration during dynamic recovery process.

摘要：当前,生物制造技术和产业是世界关注的热点。然而,生物过程优化与放大过程中普遍面临以下几个难题,包括:过程检测手段缺乏,难以满足关键指标参数的监控;细胞代谢认知匮乏,无法理性实现过程最优化调控;反应器环境差异大,导致逐级放大效率低下。文中针对以上亟待解决的关键问题,通过案例分析介绍发酵过程实时检测-动态调控-理性放大全链条关键技术创新。在未来,生物过程设计将以集成细胞生理学(时空多尺度细胞代谢模型)和流体动力学(CFD模型)的全生命周期模型为指导,推进计算机辅助设计与开发,加速生物过程实现大规模智能化生产,开启绿色生物制造新时代。

摘要：A three-dimensional finite element approach based on ABAQUS code was developed to investigate the effect of welding sequence on welding residual stress distribution in a thin-walled 6061 aluminum alloy structure. To obtain sound numerical results, the therrno-mechanical behaviour was simulated using a direct-coupled formulation. Nine different simulation sequences were carried out by single-pass TIG welding of an octagonal pipe-plate joint, and the distributions of longitudinal and transverse residual stresses both on the outer and inner surfaces of the pipe were analyzed. The results suggest that the final residual stresses in the weld and its vicinity are not affected by the initial residual stresses of the structure. Selecting a suitable welding sequence can reduce the final residual stress in an octagonal pipe-plate joint.

摘要：为加快教育赋能新质生产力,开展以“海上风电高端装备的设计制造、智能运维”为主要特色的智能风电微专业教育教学反思。以微专业的海工装备腐蚀控制课程建设为例,探索融合新质生产力的课程体系及教学模式建设创新思路和实践路径,以期实现碳中和目标下“新工科”人才培养与新质生产力的双向驱动。

摘要：目的构建了引入CpG基序的lvgA基因的真核表达质粒pclvgA/CpG,并在NIH3T3细胞中表达。方法采用PCR方法将特定CpG基序作为核酸佐剂构建于嗜肺军团菌lvgA基因侧翼,定向克隆入真核表达载体pcDNA3.1/myc-his(+),构建重组质粒pclvgA/CpG,体外阳离子脂质体转染法转染NIH3T3细胞。结果通过测序证实真核表达质粒pclvgA/CpG中lvgA/CpG克隆片段长为657bp,推测lvgA基因编码蛋白大小约为27.7Ku,lvgA基因及两侧翼原设计CpG基序完整扩出,测序序列与设计序列完全符合。用免疫荧光检测重组质粒在NIH3T3细胞中瞬时表达。结论本实验成功构建了嗜肺军团菌pclvgA/CpG真核表达质粒,并在NIH3T3细胞检测到其瞬时表达信号。