摘要：The pharmaco-dyn.mic action.of plan.-derived drugs still remain. a big challen.e in.the field of pharmacology. This applies especially for the discoverin. of the possible mechan.sm of action. With respect to the brain. surrogate parameters may be very helpful. n.n.in.asive pharmaco-EEG has been.proven.to provide valid in.ormation.on.drug effects in.gen.ral. Fast dyn.mic EEG recordin. with epoch len.th of 364 ms has n.w been.achieved in.combin.tion.with Eye-Trackin. in.order to elucidate sin.le scen.s durin. cogn.tive an. emotion.l challen.es (En.ephaloVision.. The presen. in.estigation.deals with the psychophysiological characterization.of the effect of a plan.-derived preparation.marketed in.German. un.er the n.me of PASCOFLAIR® con.ain.n. 425 mg of passion.lower extract in.subjects sufferin. from examin.tion.an.iety. Forty healthy volun.eer subjects (17 men.an. 23 woman., with ages varyin. between.18 an. 40 years (26 ± 6.726 for men.an. 25 ± 5.397 for women. were in.luded in.o the study when.havin. a score higher than.60 in.the PAF (Pr&#220fun.san.stfragebogen.. Spectral power an.lysis of pre-drug data with respect to beta waves revealed a sign.fican. correlation.to the score of the PAF. In.reases of delta, theta an. beta waves as in.uced by 4 cogn.tive an. 4 emotion.l challen.es were atten.ated in.the presen.e of 2 tablets of PASCOFLAIR® already 45 min.tes after in.ake in.a statistically sign.fican. man.er in.comparison.to placebo. Regardin. atten.ation.of beta1 an. beta2 spectral power, effects on.glutamatergic an. GABAergic n.urotran.mission. respectively, can.be suspected accordin. to our kn.wledge of frequen.y—tran.mitter relation.. Accordin.ly, this atten.ation.must be in.erpreted as ability to coun.eract examin.tion.in.uced stress symptoms. Results con.irm an. exten. earlier experimen.al data showin. a calmin. action.of PASCOFLAIR®.