摘要：长输埋地油气管线在严重的地灾作用下会引发管道变形,如果变形的管段存在缺陷,将极易导致管道失效,造成严重的环境污染和经济损失。准确地获取管道的变形情况并进行安全评价能够为保障管道安全稳定运行发挥重要的作用。基于IMU检测数据,通过小波变换降噪和油气管道设计规范进行特征识别的应变解析算法,能够有效地识别管线上的热偎弯管、冷弯管、弹性敷设段和重点关注段。该算法计算的管段弯曲拉伸应变值将结合ExxonMobil提出的拉伸应变容量预测模型对环焊缝进行基于应变的安全评价。在基于应变设计的高钢级油气管道已在国内油气运输行业得到广泛应用的背景下,可以参考该评价方法开展高钢级管道环焊缝的安全评价。

摘要：In vaccine development,broadly or cross-type neutralizing antibodies(bnAbs or cnAbs)are frequently targeted to enhance *** immunodominant antibodies could help fine-tune vaccine immunogenicity and augment the precision of immunization ***,the methodologies to capitalize on the attributes of bnAbs in vaccine design have not been clearly *** this study,we discovered a cross-type neutralizing monoclonal antibody,13H5,against human papillomavirus 6(HPV6)and *** nAb exhibited a marked preference for HPV6,demonstrating superior binding activity to virus-like particles(VLPs)and significantly higher prevalence in anti-HPV6 human serum as compared to HPV11 antiserum(90%vs.31%).Through co-crystal structural analysis of the HPV6 L1 pentamer:13H5 complex,we delineated the epitope as spanning four segments of amino acids(Phe42-Ala47,Gly172-Asp173,Glu255-Val275,and Val337-Tyr351)on the L1 surface *** interaction analysis and site-directed mutagenesis revealed that the Ser341 residue in the HPV6 HI loop plays a critical role in the interaction between 13H5 and *** Ser341 with alanine,which is the residue type present in HPV11 L1,almost completely abolished binding activity to *** swapping amino acids in the HPV11 HI loop with corresponding residues in HPV6 L1(Ser341,Thr338,and Thr339),we engineered chimeric HPV11-6HI ***,the chimeric HPV11-6HI VLPs shifted the high immunodominance of 13H5 from HPV6 to the engineered VLPs and yielded comparable neutralization titers for both HPV6 and HPV11 in mice and non-human *** approach paves the way for the design of broadly protective vaccines from antibodies within the main immunization reservoir.

摘要：针对复杂地形下串列四排桥墩局部冲刷问题,以洺河京港澳高速桥6号桥组为研究对象,以不同泥沙级配及中值粒径表征非均匀沙质河床及来沙条件,考虑泥沙水下休止角等影响因素,通过建模软件Rhino耦合Flow-3D开展三维数值模拟研究,得到串列四排桥墩周围流场结构及冲坑演变过程。将模拟得到的流速值和冲深值与物理试验结果对比,相对误差均在10%以内,表明构建的数学模型能够较好地实现复杂地形下非均质河床的四排桥墩局部冲刷数值模拟。模拟方法可为类似三维曲面数值模拟研究提供参考,对于识别桥墩周围水流结构和冲刷特性、指导桥梁规划设计具有重要的参考价值。

摘要：Porous SiC/Ti-based metallic glass composite (Ti-BMGC), a new kind of composite, has significant application prospectin the field of light armor. To evaluate the dynamic mechanical response of the composite, dynamic Vickers hardness andindentation-induced deformation behavior were investigated by comparison with that under static indentation. The dynamic hardnesswas measured by a modified split Hopkinson pressure bar (SHPB). The dynamic hardness is obviously greater than the statichardness. The brittleness parameter under dynamic indentation is also greater than that under static indentation. Although thedynamic indentation induced more severe deformation behavior than the static indentation, the deformation and fracturecharacteristics in the two loading cases are nearly the same, both exhibiting extensive cracks in the SiC phase and severe plasticdeformation in the metallic glass phase.

摘要：目前国内外学者针对地震波扰动下隧道的衬砌动力响应解析解的研究多为单层衬砌,而实际工况中隧道一般包括初衬和二次衬砌。因此,研究复合式衬砌隧道的抗震性至关重要。以深埋复合式衬砌隧道为研究对象,建立了考虑尺寸效应和非均匀性结构效应的高阶应变梯度非局部孔隙弹性计算模型,用以描述多孔介质材料和结构的具体物理特性。通过引入2个长度参数、非局部参数及尺度因子来改进Biot理论。采用波函数展开法得到了复合式衬砌的解析解。考虑深埋复合式衬砌隧道的边界条件,确定复合式衬砌隧道周围的动力集中因子大小,分析了不同入射P波频率下,尺寸因子和非局部参数对衬砌动应力集中因子大小的影响,以及内外衬砌刚度和厚度对衬砌内外边界动应力集中因子(DSCF)值的影响。结果表明:高频下,非局部参数和尺寸因子对衬砌内DSCF值的影响较大,并且非局部参数对衬砌内DSCF值有削弱的影响,尺寸因子对衬砌内DSCF值有增强的影响;低频下外衬砌刚度越大,外衬砌内DSCF值越大,内衬砌内DSCF值越小,这说明在外层衬砌不被破坏的情况下,内层衬砌适当选择刚度小一点的材料有利于隧道衬砌的安全;低频下,衬砌厚度在合理范围内越大,衬砌内DSCF值越小。解析结果可为隧道复合衬砌设计提供参考。

摘要：为研究复杂地质环境下大直径双模盾构选型技术及应用效果,以深大城际机场东站—黄麻布站区间为依托,首先分析了该区段的工程重难点和施工风险,结果表明:该区间需穿越长距离硬岩地层和部分软土地层,下穿多处重要建构筑物和穿越多条构造破碎带和节理密集带,施工风险高、难度大。因此,为兼顾盾构机在硬岩地层的掘进效率和软土及不良地质条件下的地层稳定,综合选用EPB(earth pressure balance)/TBM(tunnel boring machine)双模盾构机,并根据施工重难点对盾构机结构和功能系统进行了针对性设计。最终,对该盾构的现场工程应用进行了效果评价。结果表明:所选的EPB/TBM双模盾构能较好地满足工程需求,确保了盾构机掘进的安全性和高效性。研究成果可为其他类似条件下的双模盾构机选型提供参考和指导。

摘要：准确评估植被阻力对预测植被影响下的河流流速分布具有重要意义。采用已有研究数据,验证了6种挺水植被阻力系数公式在刚性沉水植被流计算中的适用性,并在已有研究基础上考虑淹没度影响,针对低淹没度情形,提出了改进的阻力系数公式。结果表明,各公式平均计算精度接近,计算流速与实测流速相对误差均在10.20%~15.19%之间;改进阻力系数公式计算精度良好,公式计算流速与实测流速相对误差为3.40%,可用于植被层流速估算,适用范围为淹没度1<H/h_(v)<2且固体体积分数0<ϕ≤0.02。

摘要：花岗岩力学性能随环境温度的变化是岩石力学领域的热点问题,其微细观结构随温度的演化规律尚不清晰。基于现代化测试技术和实验设备设计了等幅值温度循环和峰值递增温度循环荷载,关注其作用下花岗岩微裂隙的衍生和扩展规律,并讨论了风化程度的影响。研究结果表明峰值温度比循环次数对裂隙网络发展的影响更大,峰值递增的温度循环可促进表面裂隙的衍生,而风化在一定程度上可减弱温度荷载的影响。本文研究可促进对温度作用下岩石力学性能演化的认知。

摘要：To address the dissolution issue and enhance the electrochemical performance of organic electrode materials,herein, a bipolar organic cathode was prepared by in-situ electropolymerization of amino-phenyl carbazole naphthalene diimide(APCNDI). APCNDI is composed of n-type 1,4,5,8-naphthalene tetracarboxylic diimide that stores Li cations and p-type carbazole groups which react with anions and serve as polymerization sites. Electropolymerization completely eliminated the dissolution problem of APCNDI, and the electropolymerized cathode demonstrated a bipolar reaction with excellent electrochemical performance, stable cycling performance with a capacity retention of 92 mA h g;after1000 cycles, and a superior rate performance of 72 mA h g;at 10 A g;. The bipolar feature and reactions of APCNDI were systematically investigated and verified by multiple characterization techniques. Our findings provide a novel strategy for the design and fabrication of electrodes for high-performance organic batteries.

摘要：【目的】为快速鉴定和利用文冠果种质资源,探明文冠果种质亲缘关系。【方法】从20对SSR引物筛选得到11对条带清晰、多态性好的引物,对29个文冠果品种(系)进行分析,采用荧光毛细管电泳技术进行多态检测,通过邻接法进行聚类分析,利用数字和字母赋值编码构建分子身份证。【结果】共检测到66个等位基因(Na),每对引物检测到3-10个Na。Shannon信息指数(I)变化范围介于0.349-1.723之间,平均值为1.16。不同引物揭示的多态信息含量(PIC)变幅介于0.276-0.841,平均为0.66。观测杂合度(Ho)变幅为0.137-0.958,平均值为0.739;期望杂合度(He)变幅为0.187-0.79,平均值为0.648;在11个位点中,有7个位点的平均观测杂合度大于平均期望杂合度。遗传相似系数变化范围为0-1,平均为0.31,遗传相似系数在0.6以上的有15个,仅占全部数据的5.17%。邻接法聚类分析结果显示,在遗传距离为0.42时,可将29份文冠果种质分为三大类群。构建了0/1形式的指纹数据库和分子身份证,除个别品种外均具有唯一性,可用于品种鉴定。【结论】29份文冠果种质资源的遗传多样性相对较高,但也存在一定的近交现象。利用SSR标记构建文冠果分子身份证操作简便可行,可为文冠果品种真伪鉴定、权益保护、身份识别、溯源管理及新品种选育提供技术支撑和科学依据。