摘要：Creative regions and their formation in a region depend on several factors. These factors are effective when placed side by side and have a positive impact on the establishment of the physical system of area. In fact, continuous and chained activity of these factors will play an important map. The connection between the key factors of creative region is named creative ecosystem that starts from a point, and after a few steps becomes a creative idea. Finding this ecosystem is particularly important in formation of the creative region. With proper understanding, apropos analysis, and timely use of this chain, actual and virtual potentials of region will be stimulated and pleasant result will come out. This paper explores the creative region factors and components that can be involved in the creative ecosystem. These factors are sometimes fundamental and sometimes minor considered compared to the current situation in the region. The used research method is grounded theory and in fundamental extent, it is seeking to achieve an underlying or grounded theory. After investigations and the results of this study, a creative region cycle theory has been reached and is presented as a fundamental theory that is a basis for formation of future researches. In the cycle of creative region, innovation, social capital, creative human capital and living quality are discussed that as the criteria for the formation of a creative region have numerous separated indicators.