摘要：A series of novel 5-sulfoxide-substituted pyrazolo[5,1-d] [1,2,3,5]tetrazin-4（3H）ones 4a-j were designed and efficiently synthesized via a diazotization of 5-amine-3-methylsulfinyl- 1H-pyrazole, followed by cycloaddition with aryl isocyanate. A possible reaction mechanism is outlined and discussed. These new compounds exhibit some biological activity as preliminary bioassay indicated. Their structures were confirmed with ^1H NMR, IR and elemental analysis.

摘要：A series of novel fluorine-containing acrylates 6a-6g were synthesized via the condensation of ethyl cyanoacetate and trifluoroacetic anhydride, followed by chloridization and the coupling reaction with amines. These new compounds exhibited some biological activity as preliminary bioassay indicated. A plausible reaction mechanism was outlined and discussed.

摘要：近期,互联网中出现很多基于僵尸网络的攻击手段,为更好地防范来自网络的攻击,提出一种可能即将出现的混合结构P2P僵尸网络构架。本构架基于Chord协议,通过将多个Superbot组成一个虚拟节点,增强了僵尸网络稳定性。同时设计算法实现Superbot的自动筛选、生成、组合与更新。测试证明,该构架的稳定性和抗摧毁能力高于其他僵尸网络。

摘要：A series of 3-substituedmethylenethiochroman-4-ones was designed and synthesized, and their structures were confirmed by 1H NMR, 13C NMR, MS, IR, UV and elemental analysis. The results of their anticancer activity studies show that almost all 3-chloromethylenethiochroman-4-ones exhibit high anticancer activities and their activities are all better than reference cisplatin. Their IC50 against cancer cells is in a range of 0.80―9.17 μg/mL. Thus they could be promising candidates for anticancer drugs. However, compound 5 has no activity against cancer cells, thus chloromethylene at the 3 position of thiochroman-4-ones seems to play an important role in observed anticancer activities.

摘要：悬索桥钢箱梁桥位焊接施工环境较差,桥位焊接质量、精度控制十分关键。该文主要介绍了广州珠江黄埔大桥悬索桥钢箱梁桥位焊接工艺、焊接精度控制以及焊缝质量控制采取的措施和效果。

摘要：为推动喷射混凝土的高性能化和高耐久性发展,进行了喷射混凝土的力学性能和微观结构试验研究。试验结果表明,与基准喷射混凝土相比,各类喷射混凝土的抗压强度、抗折强度、弹性模量均有所降低。但PVA玻璃纤维喷射混凝土的抗拉强度增幅最大,相比AR玻璃纤维喷射混凝土,PVA纤维喷射混凝土表现出更优异的抗拉性能。纤维素喷射混凝土的微观孔结构性能改善最优。综合考虑,PVA喷射混凝土更适合应用于实际的喷射混凝土工程。

摘要：The question whether human nature is good or evil has been argued about throughout the *** paper contends that man’s actions are driven by his needs for self-existence and *** judgment is mostly determined by social norms,and different times may give different judgments to human *** man is good or evil depends on the actions taken in the situations and from the balance between self-existence and altru-existence in *** balance point between self-existence and altru-existence may vary from person to person and from culture to *** in the same person,at the different stages of his life or in different situations,the position of the balance point may change *** paper also applies the idea of balance point to the explanation of the formation of the Chinese national character.

摘要：从量子药理学的角度，对嘧啶（硫）醚类化合物的电子结构进行了量子化学研究．结果表明，在高活性分子的嘧啶环周围存在一个大的电负性区域，其除草活性与杂环部分的电荷转移能力有关．在上述结果的基础上，设计并合成了一类结构新颖的除草剂．生测结果表明，所设计的化合物具有很好的除草活性，其中化合物ｂ的ｐＩＣ５０达到７以上．

摘要：在换热网络的运行过程中,其操作条件时常变化。针对过程系统安全平稳运行的基本要求,基于频域稳定性分析方法,得出影响过程系统动态性能与稳定性的关键点,提出一种换热网络旁路控制系统的设计方法。从频域的角度分析潜在旁路与被控变量之间的耦合关系,采用频域相对增益阵方法实现换热网络的旁路设计。并在此基础上,对设计的控制系统进行控制器参数设计,使换热网络控制系统满足一定的稳定裕度要求。结果表明,基于频域稳定性分析设计的换热网络旁路控制系统满足稳定裕度要求,其阶跃响应的绝对误差积分值较小,系统的动态性能更好。

摘要：针对多数产品受到多种应力影响的情况,研究恒定应力和步进应力两种施加方式下多应力加速退化试验优化设计方法。以随机过程对产品性能退化建模,分析试验剖面,对恒定应力加速退化试验,采用均匀设计和均匀正交设计理论确定应力的组合方式;对步进应力加速退化试验,各应力均采用步进方式。基于D优化方法,以模型参数估计方差最小为目标,以试验费用为约束,建立优化模型,给出最优的各应力水平,各应力水平下的样本分配、试验时间分配和监测间隔。最后给出应用该方法的仿真算例。