摘要：As the Chinese Lunar New Year-Spring Festival 2025 begins,we take an opportunity to look back at the journal Bio-Design and Manufacturing(BDM for short).The journal BDM,first published in 2018,is related not only to human life and health but also to the frontier disciplines of global scientific and technological *** we highlight a few points of interest from the past year in order to encourage more readers to pay attention to this exciting field.

摘要：This report provides a highlight of the third International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC2023).BDMC2023,based on the journal of Bio-Design and Manufacturing(BDM)founded by Zhejiang University,was successfully held in Singapore on August 6–8,2023.

摘要：Bio-manufacturing,a frontier interdisciplinary subject,is a promising field full of creative thinking and innovation[1].In order to create a platform for young scientists and students in the bio-manufacturing field to have a good chance of communication and discussion,based on the success of First Bio-Design&Manufacturing Youth Forum in 2021[2],the Second Bio-Design&Manufacturing Youth Forum chaired by the editor-in-chief Academician huayong yang and jointly sponsored by the journal of Bio-Design and Manufacturing,School of Mechanical Engineering,Zhejiang University and the State Key Laboratory of Fluid Power and Mechatronic Systems was successfully held in Hangzhou on November 19,*** prestigious young scientists were invited to deliver a speech on their own research both onsite and online。

摘要：Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the *** has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable ***,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary ***,because of certain development policies,this research has not been widely recognized on an international *** paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3D)printing,and biomedical applications in the last five *** unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each ***,this review highlights the current challenges and prospects of *** viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.

摘要：Recently,Kelly and colleagues[1],inspired by computed tomography(CT),report a“volumetric additive manufacturing”technology via a computed axial lithography(CAL)approach.A related US patent application[2]has also been *** cumulative light exposure solidifies the material in the target area,while the other area remains uncured,resulting in only specific points in the designed 3D objects being *** technology significantly improves the capability of the digital light processing(DLP)***,the lithography approach based on a similar algorithm was already proposed by Xiang Wu in a patent(application ***/CN2016/080097)in 2016[3].

摘要：Developing artificial muscles that can replace biological muscles to accomplish various tasks iswhat we have long been aiming *** advances in flexible materials and 3D printing technology greatly promote the development of artificial muscle technology.A variety of flexible material-based artificial muscles that are driven by different external stimuli,including pressure,voltage,light,magnetism,temperature,etc.,have been *** these,fluid-driven artificial muscles(FAMs),which can convert the power of fluid(gas or liquid)into the force output and displacement of flexible materials,are the most widely used actuation methods for industrial robots,medical instruments,and human-assisted devices due to their simplicity,excellent safety,large actuation force,high energy efficiency,and low ***,the bio-design,manufacturing,sensing,control,and applications of FAMs are introduced,including conventional pneumatic/hydraulic artificial muscles and several innovative artificial muscles driven by functional ***’s more,the challenges and future directions of FAMs are discussed.

摘要：Cancer is characterized by a high fatality rate,complex molecular mechanism,and costly *** microenvironment of a tumor consists of multiple biochemical cues and the interaction between tumor cells,stromal cells,and extracellular matrix plays a key role in tumor initiation,development,angiogenesis,invasion and *** better understand the biological features of tumor and reveal the critical factors of therapeutic treatments against cancer,it is of great significance to build in vitro tumor models that could recapitulate the stages of tumor progression and mimic tumor behaviors in vivo for efficient and patient-specific drug screening and biological *** conventional tissue engineering methods of constructing tumor models always fail to simulate the later stages of tumor development due to the lack of ability to build complex structures and angiogenesis potential,three-dimensional(3D)bioprinting techniques have gradually found its applications in tumor microenvironment modeling with accurate composition and well-organized spatial distribution of tumor-related cells and extracellular components in the past *** capabilities of building tumor models with a large range of scale,complex structures,multiple biomaterials and vascular network with high resolution and throughput make 3D bioprinting become a versatile platform in bio-manufacturing aswell as inmedical *** this review,wewill focus on 3D bioprinting strategies,design of bioinks,current 3D bioprinted tumor models in vitro classified with their structures and propose future perspectives.

摘要：As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap *** particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ *** by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable *** further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control ***,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.

摘要：Bioprinting:a powerful tool to fabricate biomimetic tissues and organs Bioprinting is an important technology in the field of biofabrication that aims to create functional biomimetic *** flexibility,versatility and functionality of bioprinting enable the fabrication of intricate biological structures by combining cells,biomaterials or growth factors as printing bioinks[1,2].

摘要：Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent *** the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in ***,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment *** study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.