摘要：Since the PI3K signaling pathway is the most commonly activated in human cancers,inhibition of PI3K is a promising approach to cancer *** this study,a series of 2-methyl-5-nitrobenzeneacylhydrazones were designed and *** the new derivatives were tested by p110α enzymatic and Rh30 cellular *** enzyme selectivity profiling proved that 6e and 7 were potential selective PI3K inhibitors.

摘要：Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of *** this study,we describe the design,synthesis,and biological evaluation of a series of O-linked indoles as potent inhibitors of *** these compounds,18 showed significant anti-angiogenesis activities via VEGFR-2 in enzymatic proliferation assays,with IC50 value of3.8 nmol/L Kinase selectivity profiling revealed that 18 was a multitargeted inhibitor,and it also exhibited good potency against VEGFR-1,PDCFR-α and β.

摘要：Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among these compounds, 39 exhibited potent inhibitory activity against VEGFR-2 both in vitro and in vivo. The antiangiogenesis activity of 39 was further confirmed by both tube formation assay and chick chorioallantoic membrane assay.

摘要：目的以玄武岩复合材料低水平放射性固体废物箱新产品为研究对象,对其力学性能进行研究。方法基于玄武岩复合材料性能,参照《低、中水平放射性固体废物容器钢箱》(EJ1076—2014)的相关标准要求,利用ANSYS有限元软件完成了玄武岩复合材料低水平放射性固体废物箱的结构设计,并根据EJ 1076—2014等标准规则,对其进行了力学计算校核。结果以FB-Ⅲ型固体废物箱为例,其由Q235B的钢结构框架和厚度4.5 mm的玄武岩复合材料箱面组成,利用ANSYS有限元软件中的静力学和显示动力学模块,对此结构的玄武岩复合材料废物箱进行了堆码、顶部起吊、叉举、跌落等力学仿真分析,所得到的力学结果均小于EJ 1076—2014要求的限值。结论玄武岩复合材料低水平放射性固体废物箱新产品的结构设计满足设计要求,其力学评定符合EJ 1076—2014。

摘要：本文通过对不锈钢封装外壳在激光焊接过程中出现的靠近焊接区域的玻璃开裂问题进行研究,对可能造成玻璃开裂的影响因素进行分析并设计相关实验进行验证,找出了造成玻璃在激光焊接过程中出现开裂失效的主要因素。针对分析结果,对不锈钢封装外壳零部件原材料的高温处理提出相应要求,有效避免该问题的发生并为其他类似产品提供参考。

摘要：数字媒体艺术综合了信息技术、艺术创作等学科优势,利用通信技术展开艺术创作,成为未来广告传播的重要载体和表现形式。广告的目标在于传播信息,数字媒体艺术以其创意性、动态性、交互性等特征,为受众带来听视觉等感官的特别体验,极具吸引力和冲击力。

摘要：Based on the current indoor natural ventilation and lighting in the space of traditional residential buildings,this paper starts from the passive-design optimization of the spatial natural ventilation and lighting,and makes quantitative evaluation on the quality of current interior natural ventilation and lighting for two typical residential buildings by three indexes,including wind speed,static wind area ratio and satisfaction ratio about minimum lighting coefficient. Based on that, this paper conducts the passive design optimization, and establishes the quantitative association and reevaluation among the passive reformation design, natural ventilation,and lighting environmental quality,proposing the general strategy for the existing residential buildings to respond to the passive reformation design of the natural ventilation and lighting. The special reconstruction of core functionary space of integration of "the living room + dining room + partial space"is researched,and the redesign for the optimization and replacement of both indoor and outdoor enclosure parts is explored,which is expected to provide practical exploration on the strategies for passive construction of spatial natural environmental quality within a large number of highly-energy-consumed residential buildings in China,as well as the green design of residential buildings.

摘要：随着有晶状体眼后房型人工晶状体植入术的发展及可植入式接触镜(ICL)的不断改进,ICL V4c植入术目前已经成为矫正中高度近视的主流术式之一。术后拱高是评价手术安全性的重要指标,在常规ICL V4c植入手术的基础上,如何优化手术以获得更理想的拱高是近年来学者们研究的热点。本文以术前检查、术中手术设计以及术后随访为中心,总结分析优化ICL V4c植入手术的方案,为提高手术安全性提供帮助。

摘要：船式拖拉机在水田作业时,其行驶驱动力主要来源于驱动叶轮轮叶与土壤间的相互作用。为了降低船式拖拉机行驶过程中的功率损失,采用弧形轮叶来优化叶轮的驱动效率,并构建了弧形轮叶—土壤的离散元模型,通过比较弧形单轮叶在不同幅角、厚度、驱动面倾角下受到的土壤作用力(推进力和支撑力)及作业过程中不同参数的弧形轮叶与土壤流动之间的关系,以叶轮驱动效率为参考指标,对弧形轮叶结构参数进行优化。研究结果表明:当辐角为18°、厚度为8mm、驱动面倾角为6°时,轮叶驱动效率达到最大,为61.23%,相比原始直面轮叶提高了31.11%,比课题组优化得到的直面轮叶驱动效率提升了8.49%,叶轮驱动性能获得了明显提升。

摘要：Objective It is imperative to provide some consistent experimental results for the extraction of flavonid from Fructus Gardeniae. Methods The key extraction parameters that influenced the yield of flavonid from Fructus Gardeniae were optimized by employing an orthogonal experiment [L9（3）4], including the ratio of buffer solution （Na2B4O7· 10H2O） to raw material, concentration of Fructus Gardeniae in extracting solution, extraction time and pH of buffer solution. An UV/Vis detector was used to perform the qualitative and quantitative analyses of the extracted flavonid with the using of the standard sample. Results The maximum extraction yield of the crude extract was 5.0533 （mg/g） after 20 min when the mass ratio of Na2B4O7 · 10H2O to raw material was 0.4%, the concentration of Fructus Gardeniae in the extraction solution was 1/12 （g/mL）, and pH of buffer solution was 4.5. The positive reactions to the Molish and HCI-Mg tests suggested that the extracted compound was flavonoid, and FTIR measurements also identified the presence of flavonoid in the extracts. Conclusion This work is expected to provide a basis for further research, development, and utilization of Fructus gardenia in flavonid extraction.