摘要：The high incidence of cardiovascular disease has led to significant demand for synthetic vascular grafts in clinical ***-proliferation drugs are usually loaded into devices to achieve desirable anti-thrombosis effects after ***,the non-selectiveness of these conventional drugs can lead to the failure of blood vessel reconstruction,leading to potential complications in the long *** address this issue,an asymmetric membrane was constructed through electro-spinning *** bilayer membrane loaded and effectively released nitric oxide(NO),as hoped,from only one *** to the short diffusion distance of NO,it exerted negligible effects on the other side of the membrane,thus allowing selective regulation of different cells on both *** released NO boosted the growth of endothelial cells(ECs)over smooth muscle cells(SMCs)-while on the side where NO was absent,SMCs grew into *** overall structure resembled a native blood vessel,with confluent ECs as the inner layer and layers of SMCs to support *** addition,the membrane preserved the normal function of ECs,and at the same time did not exacerbate inflammatory *** preparing this material type that regulates cell behavior differentially,we describe a new method for its application in the cardiovascular field such as for artificial blood vessels.

摘要：In order to maintain the safety of underground constructions that significantly involve geo-material uncertainties,this paper delivers a new computation framework for conducting reliability-based design(RBD)of shallow tunnel face stability,utilizing a simplified inverse first-order reliability method(FORM).The limit state functions defining tunnel face stability are established for both collapse and blow-out modes of the tunnel face failure,respectively,and the deterministic results of the tunnel face support pressure are obtained through three-dimensional finite element limit analysis(FELA).Because the inverse reliability method can directly capture the design support pressure according to prescribed target reliability index,the computational cost for probabilistic design of tunnel face stability is greatly *** comparison with Monte Carlo simulation results,the accuracy and feasibility of the proposed method are ***,this study presents a series of reliability-based design charts for vividly understanding the limit support pressure on tunnel face in both cohesionless(sandy)soil and cohesive soil stratums,and their optimal support pressure ranges are *** results show that in the case of sandy soil stratum,the blowout failure of tunnel face is extremely unlikely,whereas the collapse is the only possible failure *** parametric study of various geotechnical uncertainties also reveals that ignoring the potential correlation between soil shear strength parameters will lead to over-designed support pressure,and the coefficient of variation of internal friction angle has a greater influence on the tunnel face failure probability than that of the cohesion.

摘要：To achieve secured in vivo drug synergy in stroma-rich pancreatic cancer(PDAC)is not an easy *** and Liu et *** the rational development of a ratiometrically designed nanocarrier to co-package a CDK4/6 cel cycle inhibitor palbociclib(PAL)plus an autophagy inhibitor hydroxychloroquine(HCQ)for efficient PDAC treatment The lead formulation was obtained using a computer software aided in vitro screening,followed by a remote drug co-import into a lipid-coated mesoporous silica *** ratiometric nanocarrier led to the synchronized phar-macokinetic(PK)profile and effective intratumoral buildup of the drug pair post intravenous injection,which otherwise exhibited distinctly different biodistribution *** treatment using PAL/HCQ co-delivery nanoparticle:yielded the most effective shrinkage of PDAC in subcutaneous and orthotopic PANCI mouse *** mechanistic investigation also demonstrated the activation of anti-apoptosis pathway after repetitive nanoparticle injection in mice which promoted the authors to introduce a small molecule anti-apoptosis inhibitor to further improve the performance of their already potent nanoparticle in the PDAC mouse *** work has been published online in Nature Communi cations on August 25,2020.

摘要："5.12"汶川地震导致川西高原生态环境严重破坏,为了科学、快速、实时地对川西高原大熊猫栖息地进行评估,以景观生态学和空间分析为理论基础,利用***平台和ArcEngine工具设计、实现了大熊猫生境评估系统,并提出了基于栅格数据提取适宜面积核心斑块和潜在廊道的方法.该系统良好的交互性可方便用户实现生境评估与保护区景观格局设计,为保护大熊猫生态环境提供决策支持.

摘要：地震灾害的信息化管理是实现地震灾害预测、预报和预防的基础。为了满足评价过程中对不同模型数据与因子数据的管理需求,结合ArcEngine二次开发技术,设计、实现了集灾害数据分析、灾害评价模型管理、模型应用与评价结果可视化等功能于一体的地震灾害快速评价系统,并将其应用于芦山地震滑坡灾害危险性评价过程。测试结果表明,该系统可以快速稳定完成不同模型下数据的分析与输出,有效地提高灾害信息提取的工作效率,为抗灾减灾赢取时间。

摘要：近年来,随着矿产资源开发和利用活动的不断增加,采矿企业安全、合理、合规生产变得尤为重要。但部分矿山在开采过程中,越界开采、超限开采、擅自改变开采矿种等多种违法行为时有发生。为了促进我国矿山企业绿色高效安全生产,对矿山开采进行动态监测十分必要。为此,以无人机影像数据为主要数据来源,首先针对相关矿山开采违法行为设计了矿山开采越界监测、矿山开采量监测、矿山剩余储量监测、矿山多期比对变化监测等矿山开采动态监测关键算法;然后在SuperMap Objects二次开发平台基础上设计并开发了一套矿山动态监测系统,以期为矿山动态监测提供可视化工具,为矿山违法开采判定提供技术支撑。与传统的矿山开采监测相比,所构建的矿山动态监测方法大大减少了相关技术人员的工作量,节约了大量的时间成本,具有较好的应用价值和推广前景。

摘要：生物医用材料的表界面设计在组织工程、生物医疗器械、生物传感与检测、生物芯片等领域越来越重要,深入理解材料性质,尤其是表界面性质,对生物材料研发具有一定指导作用。在生物材料表界面修饰的各种方法中,光化学修饰方法简单高效,且具有时空可控性和非侵入性等优点,已成为生物材料表界面修饰中的热点研究领域之一。本综述在介绍近年来发展的生物材料表面光化学修饰方法的基础上,集中介绍其在组织再生材料(仿细胞外基质界面、硬度调控薄膜凝胶、图案化和梯度表面、光响应动态表面)、微液滴阵列表面、高通量生物芯片等领域的应用,并进一步展望了光化学表面修饰在生物医用界面研究中的关键挑战和发展方向。

摘要：基于β-环糊精和胆固醇之间的主客体识别作用,通过对主客体分子的设计,构筑模块化的组装基元;通过主客体分子组装,将具有靶向功能的乳糖酸、成像功能的异硫氰酸荧光素和治疗作用的阿霉素引入同一超分子聚合物前药胶束中,制备得到多功能的纳米药物传递系统.研究结果表明,具有不同功能的模块基元可通过超分子主客体组装在水中自组装成一定尺寸的前药胶束,并通过二维1H NOESY谱证明了主客体作用的发生.该前药胶束具有p H值响应的药物释放行为,在细胞内涵体/溶酶体酸性环境下药物释放速率显著加快.用荧光显微镜和流式细胞仪对此聚合物前药胶束的细胞内吞行为进行了研究.在乳糖酸受体介导作用下,聚合物前药胶束能在肿瘤细胞内有效富集,并同时观察到阿霉素和异硫氰酸荧光素的荧光,用以跟踪载体在细胞内的位置.MTT的结果进一步表明,该前药胶束能有效地抑制癌细胞的增殖.

摘要：计算机技术、无线网络通信飞速发展与大量移动设备的普及,促使移动GIS技术的产生与发展。本文介绍了移动GIS的概念、特点,以及系统的关键技术,并采用面向对象的设计方法,设计并实现了移动GIS地图引擎,并在此基础上实现了POI查询、驾车导航等功能,为通用的移动GIS地图引擎的应用开发提供了一个切实可行的方案。

摘要：随着Web平台逐渐成熟,在互联网上服务的新技术陆续出现,促使地理信息系统(GIS)的功能强大、应用广泛。目前,基于浏览器应用程序的开发技术,结合Google Maps和Joomla框架的组件无疑是最引人注目的技术之一。本文分析了Google Maps在Joomla构站中的现实应用,设计了一套Google Maps在Joomla中集成的解决方案,并且阐述了组件四个功能模块的实现过程。此组件基于Google Maps API与Joomla框架,利用PHP和JavaScript脚本语言进行开发,提供了Google Maps在Joomla网站中的一种简易安装方式,实现添加标记,画线等简单应用,并对其在复杂组件环境中的应用作了初步研究。