摘要：To obtain the optimization formulation of pure cultures in Tibetan kefir, the influence of the different mixtures of five strains in the pure cultures in Tibetan kefir on the flavor components in fermented milk was studied using the mixture design. The regression model on microorganism composition and main metabolites was established. The results suggested that the predictable production of lactate reached the maximum of 8.16 g L-1, while the most predictable production of diacetyl, ethanol, and CO2 were 77.23 mg L-1, 4259 mg L-1, and 2.12 g L-1, respectively. Based on these, the response values that satisfied all expectations were optimized, and the most excellent combination was Lactococcus lactis 27%, Leuconostoc mesenteroides 37%, Lactobacillus kefiri 11%, Lactobacillus casei 10%, and Kluyveromyces rnarxianus 15%. With the aid of analysis software （Design-expert 6.0.5）, the formulation of pure cultures in Tibetan kefir can be optimized for several responses and the best formulation can be obtained.

摘要：Since the PI3K signaling pathway is the most commonly activated in human cancers,inhibition of PI3K is a promising approach to cancer *** this study,a series of 2-methyl-5-nitrobenzeneacylhydrazones were designed and *** the new derivatives were tested by p110α enzymatic and Rh30 cellular *** enzyme selectivity profiling proved that 6e and 7 were potential selective PI3K inhibitors.

摘要：A 325-MHz superconducting half-wave resonator has been designed with β = 0.51. Three shapes of the inner conductors(race track, ring shape and elliptical shape) were optimized to decrease the peak electromagnetic fields and minimize the dissipated RF power on the cavity walls. In order to suppress the operation frequency shift caused by fluctuations of the helium pressure and maximize the tuning ranges, the frequency shifts and mechanical properties were studied on the electric and magnetic areas. The helium vessel was designed to keep the mechanical structure as robust as possible.

摘要：本文从"智慧资本"、"表征资本"和"产业资本"三个方面论述了北京文化创意产业的概念,提出以创新为"智慧资本",以文化为"表征资本",以产业为"经济资本",构建以"创意"为本体,"文化"和"产业"为资本构架,"智慧资本"为自主创新动力的文化创意产业。

摘要：黑格尔哲学美学中的"艺术终结"问题成为了20世纪西方美学和艺术哲学的一个预言,一些重要理论家基于不同的文化语境对"艺术终结"的预言作出了不同的阐释,成为了当代美学和艺术哲学的热门话题。探讨黑格尔以来关于"艺术终结"问题可知,"艺术终结"问题是对不同历史时期艺术发展的不同诠释,体现的是艺术实践和艺术理论阐释的开放性,而不是作为一种人类活动的艺术的结束。

摘要：公共艺术无论作为一个艺术概念,还是作为一种城市文化的艺术实践,都体现出既肯定自身又否定自身的多重复杂性和矛盾性。本文结合公共艺术理论和公共艺术实践,从公共艺术与公共空间、公共艺术与城市文化、公共艺术与政治赞助学、公共艺术与公众四个方面论述公共艺术与城市文化的矛盾性及其复杂的张力关系。

摘要：国内外关于公共艺术问题的讨论往往注重于作为对象性客体的公共艺术作品的讨论,而对于公共领域与艺术公共性、公共性与公共艺术,尤其是公共性与公共艺术本体论的关系问题未深入研究。事实上,公共性才是公共艺术真正的本体论存在,公共艺术从根本上说是存在于公共空间领域中的艺术,无论就公共艺术的空间性存在方式,还是其时间性存在方式,都是公共空间领域中具有公共性的存在和表现,这种存在和表现方式决定它比其他任何形式的艺术都更具有公共性,并体现出公共艺术在公共空间领域中的文化意识和美学精神。在当代公共艺术建设中,这不仅是一个需要深入探讨的理论问题,更是一个城市文化生产和艺术景观塑造的实践问题。

摘要：The paper establishes the relationship between the settling efficiency and the sizes of the sedimentation tank through the process of numerical simulation, which is taken as one of the constraints to set up a simple optimum designing model of sedimentation tank. The feasibility and advantages of this model based on numerical calculation are verified through the application of practical case.

摘要：在供应商面临资金约束且分担零售商的广告费开展合作广告的情形下,探讨了收益共享契约和回购契约的协调问题,分三种情形进行讨论:正常支付(不融资模式)、零售商垫付广告费用和提前支付货款(两种融资模式)。刻画了契约实现渠道协调及完成渠道收益任意分配的资金临界条件,比较分析了两个契约的协调性:在正常支付下,两个契约等价;在资金短缺且融资下,回购契约优于收益共享契约。特别地,在提前支付下,回购契约不仅能协调供应链,还可实现渠道收益的任意分配。基于契约协调的柔性比较了三种支付模式,结果表明:提前支付模式优于垫付广告费用模式,而后者又优于正常支付模式。最后,分析了初始资金和分配份额对契约协调的影响:供应商初始资金越多,或索要的分配份额越小,供应链的协调越有可能实现。

摘要：目的观察蒲地蓝消炎口服液治疗湿热蕴结证中度寻常痤疮的有效性和安全性。方法采取多中心随机双盲对照研究设计,选取5家中心,筛选240例湿热蕴结证中度寻常痤疮受试者,随机分为试验组和对照组,每组各120例;试验组给予蒲地蓝消炎口服液,对照组给予蒲地蓝消炎口服液模拟剂;两组均联合外用克林霉素磷酸酯凝胶,每天2次,洁面后涂于患处。治疗4周,比较两组治疗前后皮损(丘疹、脓疱、粉刺)数量以及中医证候(面红、皮疹痒痛、舌苔厚腻、尿黄、便秘)积分变化,记录不良反应。结果229例受试者完成试验,其中试验组117例、对照组112例。与基线相比,用药4周的两组患者的丘疹计数、脓疱计数显著减少,试验组粉刺计数和中医证候积分显著减少,且试验组均优于对照组(P<0.05)。试验组痤疮皮损改善有效率为87.2%,高于对照组的58.0%(P<0.05)。试验组仅1例患者出现外用药膏刺激性反应。结论蒲地蓝消炎口服液可有效改善湿热蕴结证中度寻常痤疮患者皮损数量及中医证候,值得临床推广应用。