摘要：Micro-alloying design of wrought magnesium(Mg) alloys is an important strategy to achieve high mechanical properties at a low cost. In the last two decades, significant progress has been made from both theory and experiment. In the present review, we try to summarize recent advances in micro-alloying design of wrought Mg alloys from both theoretical and pragmatic perspectives, and provide fundamental data required for establishing the relationship between chemical composition and mechanical properties of Mg alloys. We start with theoretical attempts for understanding the mechanical properties of Mg alloys at different scales, by involving first principle calculations,molecular dynamics, cellular automata, and crystal plasticity. Then, the role of alloying elements is discussed for a series of promising Mg alloys such as Mg-Al, Mg-Zn, Mg-RE(rare-earth element), Mg-Sn, and Mg-Ca *** challenges in the micro-alloying design of Mg alloys are highlighted at the end. The review is expected to provide helpful guidance for the intelligent design of novel wrought Mg alloys and inspire more innovative ideas in this field.

摘要：从项目概况、小区景观规划设计原则、小区景观整体框架、主要景观节点设计、植物设计等方面具体阐述了泰州水岸帝景项目的景观规划设计。

摘要：Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a progressive disease characterized by adipose and fibrous replacement of the *** elevated testosterone levels have been implicated in the pathological process of ARVC,its exact contribution to cardiac fibrosis in ARVC remains *** this study,we analyzed the potential contribution of gender-based differences on the distribution of the low-voltage area in an ARVC cohort undergoing an electrophysiological study,which was indicated by feature ***,we established engineered cardiac spheroid models in vitro using patient-specific induced pluripotent stem cell(iPSC)-derived cardiomyocytes(iPSC-CMs)and iPSC-derived cardiac fibroblasts(icFBs).We elucidated the pathogenicity of abnormal splicing in the plakophilin-2(PKP2)gene caused by an intronic ***,pathogenic validation of the desmoglein-2(DSG2)point mutation further confirms the reliability of the ***,testosterone exacerbated the DNA damage in the mutated cardiomyocytes and further activated myofibroblasts in a chain *** conclusion,we designed and constructed an in vitro three-dimensionally-engineered cardiac spheroid model of ARVC based on clinical findings and provided direct evidence of the fibrotic role of testosterone in ARVC.

摘要：目的降低药品调配差错发生率。方法抽取医院药房中255个品规药品,统计通用名、规格、数量、有效期和内标签等标签信息,分析药品标签设计与药品调配差错的关系。结果通用名标签和剂型名标签无印刷差异;10.20%的品规字号,64.57%的规格字号,70.40%的数量字号,93.73%的有效期字号≤14号字;85.00%以上的各类标签字体颜色集中使用黑、白、蓝、绿;11.42%的规格未印刷在正面,83.92%的有效期印刷在横截面;50.00%的有效期标签使用钢印印刷;24.31%的注射液剂型在安瓿瓶上直接印刷内标签信息。结论药品标签中的通用名、剂型、规格和数量标签的字体大小、颜色和印刷位置直接影响调配差错发生率。药品标签设计应优化上述内容,降低药品调配差错发生率。

摘要：Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

摘要：文章将公共艺术实践中公众交流语境的营造、设计与实现置于网络空间文本中加以讨论,研究利用网络技术如何促进城市公共艺术实践中信息沟通和公众参与的问题。并以此为逻辑起点,探讨网络环境下公共艺术交流平台的构建方式。通过对"互联网+公共艺术"新范式的探索,勾勒出一幅较为完整的公共艺术信息交流互动技术框架图。

摘要：该研究基于山东省聊城市2024年国省道干线公路养护工程,自主研发半柔性灌浆料并施工,通过基层混合料配合比设计及施工工艺研究,提出适用于半柔性路面复合路面灌注的关键技术。研究了灌注式半柔性复合路面的抗车辙机制,分析了材料组成和结构特性对车辙问题的抵抗作用。施工工艺包括旧路面处治、基体沥青混合料铺筑和半柔性材料灌注等环节。通过改进灌浆材料配方、优化基层沥青混合料设计和施工工艺,可进一步提升路面性能。

摘要：目的建立银杏叶提取物冻干舌下片的制备方法及质量评价标准。方法通过星点设计-效应面法筛选银杏叶提取物冻干舌下片最优处方制备工艺。结果银杏叶提取物冻干舌下片最优处方为银杏叶提取物40 mg/片、普鲁兰多糖8.6 mg/片、氢氧化钠0.9 mg/片、黄原胶0.2 mg/片。结论银杏叶提取物冻干舌下片制备工艺稳定可靠,有效成分含量测定合格,可用于大规模生产。

摘要：球墨铸铁具有加工性好、成本低廉等优点,但其强度和韧性不能共存,严重限制了其低温应用。本研究采用树脂砂铸造工艺,通过添加合金元素Ti在球墨铸铁中形成TiC颗粒,制备了制氧机壳体铸件。分析了铸件材料的组织、成分和力学性能。结果表明,当Ti含量为0.03%(质量分数)时,球墨铸铁中形成细小的TiC颗粒,没有影响石墨球化,球化率达到94%,符合组织要求。拉伸试验表明,该铸件材料的强度和伸长率较QT400-18球墨铸铁分别提高了5%以上和22.8%,此外,室温冲击吸收功为17 J,高于QT400-18;低温冲击韧性较好,-20℃、-40℃冲击吸收功分别提高了10%和8%。这说明添加0.03%的Ti可以提高球墨铸铁的性能,根据晶格错配度理论讨论了强韧化机理。

摘要：在给定的限制条件下,通过从S2反问题计算出发,依靠在粗、细网格上求解三维黏性Navier-Stokes(N-S)方程的设计方法完成了某高负荷、跨声速低压风扇的气动设计.该设计方法抛弃了准三元设计对损失模型的依赖,较快的实现了跨声速风扇的气动设计.在设计结果的基础上,对风扇流场结构的分析表明,动叶顶部激波,以及激波、泄漏流和附面层的相互作用是风扇损失的主要来源.全三维的弯扭叶片设计实现了静叶的高亚声大折转角扩压流动.