摘要：说起意大利的著名城市,大部分人会在第一时间脱□而出罗马、米兰、佛罗伦萨或威尼斯。其实在意大利北部的皮埃蒙特大区(Piemonte),还有一座历史悠久、工业发达、美食众多的大城市,但一直以来被世人知晓和了解的程度远远不及前面提到的那几座,它就是都灵(Turin)。

摘要：Following dental implantation,the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation,which can negatively impact osseointegration and cause implant *** improve soft tissue sealing around the implant,enhance osseointegration,and improve implant success rates,this paper proposes a composite multifunctional coating(PHG)prepared using gelatin and polydopamine/hydroxyapatite nanoparticles,investigates the effects of this novel coating on cell adhesion,proliferation,antibacterial activity,osteogenic differentiation,and evaluates its immune-related *** PHG coating was proved to have satisfactory hydrophilicity and wettability for cell ***,it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts,indicating its adhesion-promoting ***,bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated ***,the PHG coating exhibited antibacterial activity against Streptococcus mutans,as well as anti-inflammatory effects,potentially via the regulation of ***,the proposed PHG coating may promote soft tissue sealing and bone bonding,providing a potential strategy for the surface modification of dental implants.

摘要：以聚乙二醇(PEG)为软段,六亚甲基二异氰酸酯为硬段,三聚氰胺为交联剂,制备出交联聚氨酯(CLPU),研究了不同PEG分子量对其相变性能的影响.结果表明,CLPU的焓值和相变温度随PEG分子量的改变而发生规律性变化,其中以PEG2000为原料制备的聚氨酯固固相变材料(PU-SSPCM),相变温度(T_(m)=39.9℃,T_(c)=8.7℃)在人体舒适温度区间,焓值在56.6 J/g以上,100次热循环后其性能基本保持不变.此外,还探讨了三聚氰胺含量对CLPU2000性能的影响,结果表明,随着三聚氰胺含量的增加,所得聚氨酯的焓值会降低,而相变温度则略有上升.所得聚氨酯体系具有良好的相变调温功能,将其置于手心100 s后与体温仍有3.8℃的温差.该材料体系在人体热管理领域具有广阔的应用前景,有望在智能调温服装、红外隐身等领域发挥重要作用.

摘要：Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as "un druggable''.In this review, we summarized the curre nt situatio n of "undruggable" targets, and the desig n strategies for "un druggable" targets, hoping to provide references for the development of innovative drugs.

摘要：Silicon suboxide(SiOx)is considered to be one of the most promising materials for next-generation anode due to its high energy *** its preparation,the wet-chemistry method is a cost-effective and readily scalable route,while the so-derived SiOx usually shows lower capacity compared with that prepared by high temperature-vacuum evaporation ***,we present an elaborate particle structure design to realize the wet-chemistry preparation of a high-performance SiOx/C ***-like highly porous SiOx particle coated with conformal carbon layer is designed and *** highly-porous SiOx skeleton provides plenty specific surface for intimate contact with carbon layer to allow a deep reduction of SiOx to a low O/Si ratio at relatively low temperature(700℃),enabling a high specific *** abundant mesoscale voids effectively accommodate the volume variation of SiOx skeleton,ensuring the high structural stability of SiOx@C during lithiation/delithiation ***,the three-dimensional(3D)conformal carbon layer provides a fast electron/ion transportation,allowing an enhanced electrodereaction *** to the optimized O/Si ratio and well-engineered structure,the prepared SiOx@C electrode delivers an ultra-high capacity(1,115.8 mAh·g^-1 at 0.1 A·g^-1 after 200 cycles)and ultra-long lifespan(635 mAh·g^-1 at 2 A·g^-l after 1,000 cycles).To the best of our knowledge,the achieved combination of ultra-high specific capacity and ultra-long cycling life is unprecedented.

摘要：In this paper, we present a novel design scheme of temperature-jump(T-jump) area for microfluidic *** simulation and experimental research of thermal characteristics of the solution in microchannels is *** simulation of the temperature-jump microchannel is analyzed to study the heat transfer characteristics by comparing performance of three proposed *** of the power requirement is discussed in the dimensional design of microheater. Temperature-sensitive fluorescent dye is applied to investigate the temperature field of microchannel heated by a designed microheater. It is found that the T-jump microfluidic device can provide rapid heating for solutions with strong convection heat transfer ability.

摘要：We present a ballistocardiogram(BCG)measurement system for obtaining the BCG *** performance of the BCG measurement system was tested,including the dynamic response frequency of the platform(32 Hz with a 75 kg load),and the signal to noise ratio of the system(minimum 23 dB).Factors that could influence BCG recording during measurement were investigated by collecting data from 48 healthy subjects(28 males and 20females).The basic features of the BCG signal,such as the amplitude and time interval,were extracted,and differences by gender were analyzed.A correlation between the IJ amplitude(amplitude difference between I-and J-peak)and the respiration phase was found(R2=0.49).The BCG signals for both sitting(SiBCG)and standing(StBCG)postures were obtained using this *** showed that the StBCG amplitudes were larger than those of SiBCG but there was no significant difference in the time *** robustness of our system was verified,and its potential for non-invasive cardiac activity monitoring was demonstrated.

摘要：Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing *** to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly *** near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/*** this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR ***,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of ***,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence *** includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence *** the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed.

摘要：无机化学作为大学化学的基础课程,涉及知识点较多,同时知识点之间独立性强,学生往往难以形成系统全面的知识架构。为了实现各章节知识点之间更深入的逻辑关联,本文以“合成氨”及其衍生反应为线设计多点串联的系列教学案例,精编综合例题,从气相反应、溶液行为和微观结构三个层面分别串联化学反应原理、水溶液中四大平衡及原子和分子结构等知识点,辅以思维导图,将无机化学的重要知识点融会贯通,融合课程思政,使学生达成思维训练,完成知识内化的同时实现专业课程对学生的价值引领作用。教学实践显示,该教学设计不仅有利于引导学生理解知识点之间的关联,便于进行复习和记忆,更有助于提高学生知识迁移能力,掌握深度学习的方法。

摘要：Catalysts for CO_(2)value-added conversion have been extensively explored,but there is still a lack of systematic design for catalysts that achieve efficient CO_(2)conversion under mild ***,we explored a mesoporous CeO_(2)single-crystal formed with the regulation of ionic liquids,which catalyzed the effective carbonylation reaction with CO_(2)under mild reaction *** altering the synthetic environment,a series of uniform mesoporous CeO_(2)particles with atomically aligned single-crystal frameworks were constructed,which have different surface physicochemical properties and primary aggregation *** prepared mesoporous CeO_(2)single-crystal achieved efficient activation of CO_(2)and alcohols at 0.5 MPa CO_(2)and 100℃,and the CeO_(2)-IL-M catalyst shows optimal catalytic performance in the synthesis of ethylene carbonate with 46.22 mmol g^(–1)h^(–1),which was 50.6 times as high as that of the CeO_(2)obtained without ionic ***,the catalytic pathway and mechanism of carbonylation reaction with CO_(2)on mesoporous CeO_(2)single-crystal were studied via React-IR spectra and C18O_(2)labeling *** research provides a new strategy for controllable nanoscale assembly of mesoporous single-crystal materials and expands the application range of single-crystal materials,aiming to develop novel catalytic materials to meet industrial needs.