摘要：Following dental implantation,the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation,which can negatively impact osseointegration and cause implant *** improve soft tissue sealing around the implant,enhance osseointegration,and improve implant success rates,this paper proposes a composite multifunctional coating(PHG)prepared using gelatin and polydopamine/hydroxyapatite nanoparticles,investigates the effects of this novel coating on cell adhesion,proliferation,antibacterial activity,osteogenic differentiation,and evaluates its immune-related *** PHG coating was proved to have satisfactory hydrophilicity and wettability for cell ***,it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts,indicating its adhesion-promoting ***,bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated ***,the PHG coating exhibited antibacterial activity against Streptococcus mutans,as well as anti-inflammatory effects,potentially via the regulation of ***,the proposed PHG coating may promote soft tissue sealing and bone bonding,providing a potential strategy for the surface modification of dental implants.

摘要：以聚乙二醇(PEG)为软段,六亚甲基二异氰酸酯为硬段,三聚氰胺为交联剂,制备出交联聚氨酯(CLPU),研究了不同PEG分子量对其相变性能的影响.结果表明,CLPU的焓值和相变温度随PEG分子量的改变而发生规律性变化,其中以PEG2000为原料制备的聚氨酯固固相变材料(PU-SSPCM),相变温度(T_(m)=39.9℃,T_(c)=8.7℃)在人体舒适温度区间,焓值在56.6 J/g以上,100次热循环后其性能基本保持不变.此外,还探讨了三聚氰胺含量对CLPU2000性能的影响,结果表明,随着三聚氰胺含量的增加,所得聚氨酯的焓值会降低,而相变温度则略有上升.所得聚氨酯体系具有良好的相变调温功能,将其置于手心100 s后与体温仍有3.8℃的温差.该材料体系在人体热管理领域具有广阔的应用前景,有望在智能调温服装、红外隐身等领域发挥重要作用.

摘要：数据的不断增长对云的存储空间、安全、性能等的需求与日俱增.安全去重技术能够有效减少云存储空间需求的同时保障数据去重的安全性.然而,当前主流云安全去重方案依赖于可信第三方来进行密钥安全性保障,这引入了额外的信任假设和密钥管理开销.而两方的去重方案在安全和传输开销方面面临较大挑战.针对该问题,本文提出了一种基于英特尔软件防护扩展(Intel software guard extension, Intel SGX)的云数据安全去重方法,该方法的主要创新在于:(1)设计基于边缘端去重的云边协同安全体系架构,减少了云边之间的传输开销,使用SGX可信执行环境保障了云和边缘端数据和密钥的安全,无需不可信的第三方密钥服务器;(2)提出低开销的密钥安全生成协议,通过云边协同生成密钥,为每个边缘端用户生成唯一的加密密钥,而非为每个数据生成单独的密钥;(3)设计高效的基于标签流行度的标签查询机制.通过计算标签频率,实现冷热标签分离,在提高标签查询效率的同时避免标签误检.安全性理论证明和系统实验测试表明,本文的方案在安全性方面优于最新方法,并大大减少了密钥管理开销和标签查询开销,其中密钥存储开销可节省48.72%~98.72%.

摘要：Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as "un druggable''.In this review, we summarized the curre nt situatio n of "undruggable" targets, and the desig n strategies for "un druggable" targets, hoping to provide references for the development of innovative drugs.

摘要：Silicon suboxide(SiOx)is considered to be one of the most promising materials for next-generation anode due to its high energy *** its preparation,the wet-chemistry method is a cost-effective and readily scalable route,while the so-derived SiOx usually shows lower capacity compared with that prepared by high temperature-vacuum evaporation ***,we present an elaborate particle structure design to realize the wet-chemistry preparation of a high-performance SiOx/C ***-like highly porous SiOx particle coated with conformal carbon layer is designed and *** highly-porous SiOx skeleton provides plenty specific surface for intimate contact with carbon layer to allow a deep reduction of SiOx to a low O/Si ratio at relatively low temperature(700℃),enabling a high specific *** abundant mesoscale voids effectively accommodate the volume variation of SiOx skeleton,ensuring the high structural stability of SiOx@C during lithiation/delithiation ***,the three-dimensional(3D)conformal carbon layer provides a fast electron/ion transportation,allowing an enhanced electrodereaction *** to the optimized O/Si ratio and well-engineered structure,the prepared SiOx@C electrode delivers an ultra-high capacity(1,115.8 mAh·g^-1 at 0.1 A·g^-1 after 200 cycles)and ultra-long lifespan(635 mAh·g^-1 at 2 A·g^-l after 1,000 cycles).To the best of our knowledge,the achieved combination of ultra-high specific capacity and ultra-long cycling life is unprecedented.

摘要：In this paper, we present a novel design scheme of temperature-jump(T-jump) area for microfluidic *** simulation and experimental research of thermal characteristics of the solution in microchannels is *** simulation of the temperature-jump microchannel is analyzed to study the heat transfer characteristics by comparing performance of three proposed *** of the power requirement is discussed in the dimensional design of microheater. Temperature-sensitive fluorescent dye is applied to investigate the temperature field of microchannel heated by a designed microheater. It is found that the T-jump microfluidic device can provide rapid heating for solutions with strong convection heat transfer ability.

摘要：We present a ballistocardiogram(BCG)measurement system for obtaining the BCG *** performance of the BCG measurement system was tested,including the dynamic response frequency of the platform(32 Hz with a 75 kg load),and the signal to noise ratio of the system(minimum 23 dB).Factors that could influence BCG recording during measurement were investigated by collecting data from 48 healthy subjects(28 males and 20females).The basic features of the BCG signal,such as the amplitude and time interval,were extracted,and differences by gender were analyzed.A correlation between the IJ amplitude(amplitude difference between I-and J-peak)and the respiration phase was found(R2=0.49).The BCG signals for both sitting(SiBCG)and standing(StBCG)postures were obtained using this *** showed that the StBCG amplitudes were larger than those of SiBCG but there was no significant difference in the time *** robustness of our system was verified,and its potential for non-invasive cardiac activity monitoring was demonstrated.

摘要：无机化学作为大学化学的基础课程,涉及知识点较多,同时知识点之间独立性强,学生往往难以形成系统全面的知识架构。为了实现各章节知识点之间更深入的逻辑关联,本文以“合成氨”及其衍生反应为线设计多点串联的系列教学案例,精编综合例题,从气相反应、溶液行为和微观结构三个层面分别串联化学反应原理、水溶液中四大平衡及原子和分子结构等知识点,辅以思维导图,将无机化学的重要知识点融会贯通,融合课程思政,使学生达成思维训练,完成知识内化的同时实现专业课程对学生的价值引领作用。教学实践显示,该教学设计不仅有利于引导学生理解知识点之间的关联,便于进行复习和记忆,更有助于提高学生知识迁移能力,掌握深度学习的方法。

摘要：Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing *** to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly *** near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/*** this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR ***,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of ***,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence *** includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence *** the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed.

摘要：产品设计是面向用户需求的反复迭代并逐步进化的创造性活动,其核心是多领域知识应用。为了解决产品设计中知识可视化程度低、人机交互下知识推理弱等问题,提高产品设计智能化程度,提出了基于知识图谱(Knowledge graph, KG)技术的产品交互式设计知识应用模型。首先,基于产品设计活动间的作用与交互演进机制,分析产品设计问题与求解知识间的关联关系,构建一种可扩展的多层产品设计知识图谱(An expandable multi-layer knowledge graph for product design, m-KGPD)用以结构化组织多领域、跨学科求解知识,建立知识需求-求解知识信息检索通道。其次,利用数据标注平台doccano开展知识文本标注和模型训练集构建并基于双向编码表征模型-双向长短时记忆网络-条件随机场(BERT-BiLSTM-CRF)模型开展求解知识实体关系抽取,减轻在大规模文本知识提取工作中的人工重复性操作,利用知识图谱可视化平台Graph XR完成图谱搭建。最后,基于交互式遗传算法(Interactive genetic algorithm,IGA)提出满足产品交互式设计演进规律的求解知识集迭代化推理方法,通过人机混合交互方式为产品设计知识需求匹配最优求解知识集。以复杂地形多岩层成孔装备交互设计过程为例,验证了方法的可行性与有效性。