摘要：Background Chronic obstructive pulmonary disease(COPD)is a severe public health *** smoke(CS)is a risk factor for COPD and lung *** underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain *** this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung *** An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with *** levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent *** junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western *** cytometry was performed to investigate the effects of this proto-oncogene on cell cycle *** Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic *** exposure induced the degradation of intercellular connections and triggered the EMT *** exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with *** CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial ***0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer.

摘要：This paper studies the transfer path planning problem for safe transfer of an aircraft on the aircraft carrier flight deck under a poor visibility condition or at ***,we analyze the transfer path planning problem for carrier-based aircraft on the flight deck,and define the objective to be optimized and the constraints to be ***,to solve this problem,the mathematical support models for the flight deck,carrier aircraft entity,entity extension,entity posture,entity conflict detection,and path smoothing are established,as they provide the necessary basis for transfer path planning of the aircraft on the aircraft ***,to enable automatic transfer path planning,we design a multi-habitat parallel chaos algorithm(called KCMPSO),and use it as the optimization method for transfer path ***,we take the Kuznetsov aircraft carrier as a verification example,and conduct *** simulation results show that compared with particle swarm optimization,this method can solve the transfer path planning problem for an aircraft on the aircraft carrier flight deck better.

摘要：Composite-metal joints with a metal insert are one kind of connecting *** this paper,tensile experimental tests were carried out to investigate tensile properties of a compositemetal joint with a novel metal insert *** element models of the joint were established,and strain distribution and tensile strength were *** numerical results are in good agreement with the experimental *** show that the joint failure is dominated by shear properties of the resin *** the resin layer thickness in a certain range will improve the tensile strength of the joint,while increasing the radius of the fillet on the ending side of the metal insert will decrease the joint *** the resin layer plasticity will improve the joint *** effect of the embedded depth of the metal insert can be ignored.

摘要：Pathogen/microbe-associated molecular patterns(PAMPs/MAMPs) are recognized by plant pattern recognition receptors(PRRs)localized on the cell surface to activate immune *** PAMP-triggered immunity(PTI) confers resistance to a broad range of pathogenic microbes and,therefore,has a great potential for genetically engineering broad-spectrum resistance by transferring PRRs across plant *** effectors secreted by phytopathogens often directly target and inhibit key components of PTI signaling pathways via diverse biochemical *** some cases,plants have evolved to produce decoy proteins that mimic the direct virulence target,which senses the biochemical activities of pathogenic *** kind of perception traps the effectors of erroneous targeting and results in the activation of effector-triggered immunity(ETI) instead of suppressing *** mechanism suggests that artificially designed decoy proteins could be used to generate new recognition specificities in a particular *** this review,we summarize recent advances in research investigating PAMP recognition by PRRs and virulence effector surveillance by decoy *** expansion of recognition specificities,conferred by the transgenic expression of EF-Tu receptor(EFR) and AvrPphB susceptible 1(PBS1) decoys,has highlighted the considerable potential of PRRs and artificially designed decoys to expand plant resistance spectra and the need to further identify novel PRRs and decoys.

摘要：针对灵活高效的区域探测和数据回传任务,研究了时分复用模式下无人机雷达通信一体化系统(IRCS)的时间资源分配、功率资源分配和无人机轨迹的联合优化问题,以达到最大化系统雷达探测链路和通信传输链路的加权总容量的目的。为解决该非凸优化问题,采用了块坐标下降(BCD)算法及逐次凸逼近(SCP)技术,迭代优化时间资源分配、功率资源分配和无人机轨迹。仿真结果表明,所提方案可以得到收敛解,并且可以有效提升系统容量。

摘要：The continuous growth in the scale of unmanned aerial vehicle (UAV) applications in transmission line inspection has resulted in a corresponding increase in the demand for UAV inspection image processing. Owing to its excellent performance in computer vision, deep learning has been applied to UAV inspection image processing tasks such as power line identification and insulator defect detection. Despite their excellent performance, electric power UAV inspection image processing models based on deep learning face several problems such as a small application scope, the need for constant retraining and optimization, and high R&D monetary and time costs due to the black-box and scene data-driven characteristics of deep learning. In this study, an automated deep learning system for electric power UAV inspection image analysis and processing is proposed as a solution to the aforementioned problems. This system design is based on the three critical design principles of generalizability, extensibility, and automation. Pre-trained models, fine-tuning (downstream task adaptation), and automated machine learning, which are closely related to these design principles, are reviewed. In addition, an automated deep learning system architecture for electric power UAV inspection image analysis and processing is presented. A prototype system was constructed and experiments were conducted on the two electric power UAV inspection image analysis and processing tasks of insulator self-detonation and bird nest recognition. The models constructed using the prototype system achieved 91.36% and 86.13% mAP for insulator self-detonation and bird nest recognition, respectively. This demonstrates that the system design concept is reasonable and the system architecture feasible .

摘要：The sound insulation performance of railway car body structures is critical for the control of rail vehicle interior *** sound transmission loss(STL)measurements,a niche with a large depth is necessary to allow for mounting the wide range of thicknesses of railway car body panels and for the mechanical isolation of the two *** this study,two typical interior floor panels are tested in a series of mounting conditions and mechanical boundary *** change of STL results during measurement is also predicted by an STL prediction model based on the finite element *** lower frequencies,the STL results are influenced by both the mounting positions and the mechanical boundary *** higher frequencies,the STL results are mainly influenced by the mechanical boundary *** between the panel in the infinite baffle and niches at the resonance and off-resonance frequencies are *** both the effects of mounting positions and mechanical boundary conditions,the existence of the cavity amplifies the STL difference caused by the mechanical boundary conditions.

摘要：A new substrate,aligned Ag nanowires decorated with silver nanoparticle composite structure(AgNWs@AgNPs),was fabricated to investigate metalenhanced fluorescence(MEF) and its *** new composite structure was fabricated via a three-phase interface assembly method followed by SnCl2 sensitization and AgNO3 reduction *** size and distribution of the nanoparticles on silver nanowires increased with the sensitization and reduction *** formation of AgNPs on the surfaces of AgNWs was confirmed by multiple characterization methods including scanning electron microscopy(SEM),transmission electron microscope(TEM),atomic force microscopy(AFM) and X-ray diffraction(XRD).The results show that the fluorescence intensity of the poly(3-hexylthiophene)(P3HT) on the composite structure was greatly enhanced compared with that on bare glass substrate,and the intensity increased with the increase in particle sizes and *** mechanism was basedo n the increase in excitation rate and the radiation decay *** new type of substrate could serve as a good and efficient MEF substrate for high-performance fluorescence-based devices.

摘要：Domestic solar hot water system, the use of the status quo and existing problems, by analyzing the solar water heating equipment and building integrated and building integrated design.

摘要：Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely applied in biosensor,immune sensor,and fluorescent imaging agents[9,10].