摘要：An experimental muon source(EMuS) will be built at the China Spallation Neutron Source(CSNS). In phase I of CSNS, it has been decided that EMuS will provide a proton beam of 5 kW and 1.6 GeV to generate muon beams. A 128-channel muon spin rotation/relaxation/resonance(μSR) spectrometer is proposed as a prototype surface muon spectrometer in a sub-branch of EMuS. The prototype spectrometer includes a detection system, sample environment, and supporting mechanics. The current design has two rings located at the forward and backward directions of the muon spin with 64 detectors per ring. The simulation shows that the highest asymmetry of approximately 0.28 is achieved by utilizing two 10-mm-thick brass degraders. To obtain the optimal asymmetry, the two-ring structure is updated to a four-ring structure with 32 segments in each ring. An asymmetry of 0.42 is obtained through the simulation, which is higher than that of all the current μSR spectrometers in the world.

摘要：为了研究输电塔半刚性连接钢管构件的轴压稳定性能,对60根钢管试件进行了轴压试验,分析了其失稳破坏模式和稳定承载力,并与现行设计规范计算的承载力进行了对比;建立了半刚性连接钢管构件的有限元模型,经与试验结果对比验证后开展了参数分析,研究了初始转动刚度、径厚比、材料强度以及初始缺陷对半刚性连接钢管构件的稳定系数-长细比曲线的影响;基于有限元分析的结果提出了半刚性连接钢管构件的轴压稳定计算公式。研究结果表明:半刚性连接构件的试验稳定承载力均大于铰接构件的试验稳定承载力,在所有试验工况中两者的相对差距最小为5.6%;中国和美国现行设计规范计算得到的钢管构件稳定承载力总体偏保守,分别约为试验结果的0.78倍和0.89倍;影响半刚性连接钢管构件稳定承载力的主要因素为长细比、初始转动刚度以及边界条件;提出的半刚性连接钢管构件轴压稳定计算公式能准确地预测其稳定系数并具有良好的适用性,可为实际工程提供参考。

摘要：The main reason for the high strength in near-βtitanium alloys is the ultrafine precipitation of the acicular secondary a phase in theβ*** purpose of this study is to use the pseudo-spinodal mechanism to obtain the ultrafine a phase for the design of a new high-strength near-γtitanium *** calculations and TC21-(TC21+15 Mo)diffusion couple composition gradient experiments were used to demonstrate that TC21+3 Mo alloy can undergo a pseudo-spinodal decomposition to obtain the ultrafine a phase,resulting in a high-strength *** adjusting the heat treatment process to obtain a bimodal microstructure,the alloy exhibits a good balance between ultimate tensile strength(1351 MPa)and plasticity(8.5%strain).Thus,it was demonstrated that the pseudospinodal mechanism combined with a high-throughput diffusion couple technique is an effective method for designing high-strength titanium alloys.

摘要：A novel 22MnMoB hot stamping steel was designed. The continuous cooling transformation （CCT） measurement of the 22MnMoB steel showed that the ferrite-bainite microstructure could be obtained at cooling rates lower than 25 ℃/s, and the complete martensite structure required the cooling rate higher than 30 ℃/s. The experiments with non-uniform die temperatures were carried out to obtain tailored properties. The results showed that strength of 1 411 MPa and elon- gation of 6% could be obtained in the hard zone, and strength of 916 MPa and elongation of 9% could be obtained in the soft zone, which can be realized by controlling the die temperature at 400 ℃. The transition zone was found smooth and could be beneficial to reduce the stress concen tration and therefore improve the performance of components.

摘要：Malaria still threatens global health seriously *** the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors,multi-targeting inhibitors are highly desired to overcome the increasingly serious drug ***,we performed a structure-based drug design on mitochondrial respiratory chain of Plasmodium falciparum and identified an extremely potent molecule,RYL-581,which binds to multiple protein binding sites of *** simultaneously(allosteric site of type Ⅱ NADH dehydrogenase,Q_(o) and Q_(i) sites of cytochrome bc_(1)).Antimalarials with such multiple targeting mechanism of action have never been reported ***-581 kills various drug-resistant strains in vitro and shows good solubility as well as in vivo *** structurebased strategy for designing RYL-581 from starting compound may be helpful for other medicinal chemistry projects in the future,especially for drug discovery on membrane-associated targets.

摘要：A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors,with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key *** in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test（OGTT）,and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.

摘要：TiO2 pigments are typically coated with inert layers to suppress the photocatalytic activity and improve the weatherability. However, the traditional inert layers have a lower refractive index compared to TiO2, and therefore reduce the lightening power of TiO2. In the present work, a uniform, amorphous, 2.9-nm-thick TiO2 protective layer was deposited onto the surface of anatase TiO2 pigments according to pulsed chemical vapor deposition at room temperature, with Ti Cl4 as titanium precursor. Amorphous TiO2 coating layers exhibited poor photocatalytic activity, leading to a boosted weatherability. Similarly, this coating method is also effective for TiO2 coating with amorphous SiO2 and SnO2 layers. However, the lightening power of amorphous TiO2 layer is higher than those of amorphous SiO2 and SnO2 layers. According to the measurements of photoluminescence lifetime, surface photocurrent density, charge-transfer resistance, and electron spin resonance spectroscopy, it is revealed that the amorphous layer can prevent the migration of photogenerated electrons and holes onto the surface, decreasing the densities of surface electron and hole, and thereby suppress the photocatalytic activity.

摘要：北京散裂中子源(BSNS)的主加速器——快循环同步加速器(RCS)采用H^-剥离注入方法,将从直线加速器预加速的束流进行累积和进一步加速．束流损失率的控制是该类高功率质子加速器所面临的关键问题之一,而束流损失中很重要的部分是由空间电荷效应造成的．为了减小该类束流损失,注入系统设计中利用H^-剥离注入和相空间涂抹方法将直线加速器预加速的发射度较小的束流尽可能均匀地涂抹到较大的横向相空间中．与其他的类似加速器相比,RCS注入系统将所有注入元件放在一个长为9m的无色散漂移节中以充分节省RCS环的纵向空间,并使对注入系统的操作与对RCS主体的操作完全独立．对于RCS累积的粒子数1．9×10^(13),空间电荷效应对粒子的运动有非常重要的作用,本文介绍了采用ORBIT程序进行三维模拟计算并进行设计优化的结果．还介绍了系统设计时需要考虑的其他重要因素,如质子穿越、电子收集等．

摘要：为了有效地减轻火炮质量,对某火炮上架进行了结构优化设计.运用有限元分析和结构拓扑优化设计相结合的方法,依据火炮发射时上架的结构受力特性及其技术设计要求,建立了优化数学模型;利用OptiStruct软件对上架进行了结构拓扑优化.根据优化结果设计的上架结构,质量减小12.17%,刚强度性能满足设计要求.该方法可用于指导火炮其它部件的结构优化设计和轻量化设计.

摘要：通过将聚束器腔体等效为 RLC并联回路 ,求得了功率馈入耦合环与腔体的互感及自感的公式 ,根据对腔体的计算结果求出了在聚束器的工作频段内达到阻抗匹配所要求的互感变化范围 ,并在该互感变化范围内设计了可移动的耦合电感环 ,计算了它的自感及整个腔体的剩余电感。