摘要：A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection *** meet these requirements,the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating *** effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were *** tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube ***-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(N·m)due to adhesive and ***-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase *** coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia *** findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

摘要：In order to search for potent and environmental friendly insecticides with new modes of action, a series of pyranoside derivatives mimicking D-myo-inositol 1,4,5-trisphosphate （IP3） were designed and synthesized according to the bioisosterie approach. The biological assay indicated that most of the new compounds showed moderate to good insecticidal activities against oriental armyworm （Mythimna separata） and diamondback moth （PluteIla xylostella）. Especially, compound 5g displayed 80% larvicidal activity against oriental armyworm at 50 mg/L. Meanwhile, 5a showed 100% and 70% larvicidal activities against diamondback moth at 50 and 25 nag/L, respectively. To further explore the mode of action, calcium imaging technique was applied to study the effects of 5a, 5g, and 5i on the intracellular calcium ion concentration （[Ca^2＋]i） in central neurons isolated from Spodoptera exigua. The results indicated that the tested compounds released stored calcium ions from endoplasmic reticulum.

摘要：In order to discover potential ryanodine receptor insecticides, 21 novel anthranilic diamides analogues ( C , D , E , and F ) containing amide, carbamate, urea, and thiourea moieties were designed and synthesized based on bioisosteric approach. The biological assays against oriental armyworm ( Mythimna separata ) and diamondback moth ( Plutella xylostella ) indicated that these compounds displayed moderate to excellent activities. Especially, compound D 1 showed 100% larvicidal activities against oriental armyworm at 1.0 mg•L −1 , equivalent to the standard chlorantraniliprole (100%, 1.0 mg•L −1 ). Moreover, the larvicidal activity of D 1 against diamondback moth was 100% at 0.1 mg•L −1 , more effective than that of chlorantraniliprole (90%, 0.1 mg•L −1 ). Therefore, D 1 can be used as a new lead structure for the development of insecticidal agents. The preliminary structure‐activity relationship showed that the introduction od carbamate groups into 4‐position on the benzene ring of the N ‐phenylpyrazole moiety has a positive effect on the larvicidal activities.

摘要：To discover novel strobilurins analogues with good and broad spectrum activity,a series of nove 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides-based strobilurins was designed,synthesized,and tested agains various phytopathogenic *** *** 7k exhibited substantial and broad spectrum antifungal activities against the tested phytopathogenic fungi,especially compound 7b,which showed 100%,80%,90%,and 90%antifungal activity(in virto)against Erysiphe graminis(***),Puccinia sorghi Schw:(P sorghi Schw.)Colletotrichum lagenarium(***),and Pseudoperonospora cubensis(P cubensis)at 300 ug/mL,*** or comparable to the positive control ***,compound 7b exhibited 85%greenhouse *** activity(in vivo)against *** even at 0.2μg/mL,equal to azoxystrobin(90%)and trifloxystrobin(90%)Meanwhile,compound 7b against P cubensis displayed 70%and 55%greenhouse inhibition activity(in vivo)at 1.56 and 0.2μg/mL,respectively,much better than those of azoxystrobin and trifloxystrobin(both 0%at 1.56 and 0.2 ug/mL).Therefore,compound 7b could be considered as the most promising fungicidal candidate for furthe ***,based on the effective concentration(ECso)against ***,the built CoMSIA model provided the useful reference for the further structural optimization design.

摘要：Due to the conceptual clarity and calculational simplicity, practical methods for seismic analysis have been widely used in seismic design and calculation of underground structures. All of the commonly adopted practical methods assume that the earthquake inertia force of the analysis model equals that of free-field. However, this assumption neglects the influence of underground structures on their surrounding soil layers, and may lead to significant errors in both conceptual and computational terms when the size of a structure increases. This article focuses on the practical seismic analysis of large underground *** derivation is demonstrated on the basis of the establishment of mechanical models of the soil-structure system and free-field, and consequently, the quantitative relation between the seismic acceleration response of the soil-structure system and that of free-field is obtained. This relation can be used to revise the earthquake inertia force applied to the analysis model so that the calculation accuracy is effectively improved. By doing so, a revised pushover analysis method, which combines the traditional pushover analysis and theoretical derivation, is proposed in order to be appropriate to seismic analysis of large underground structures. Moreover, an example of application of the proposed method is given, in which a selected large underground structure is analyzed. The results show that this revised method has higher efficiency than the traditional method thanks to the revision of the earthquake inertia force.

摘要：Pushover analysis is common because of its conceptual simplicity and computational attractiveness in computing seismic *** that traditional pushover analysis is restricted in underground structures due to the stark differences in the seismic response characteristics of surface structures,this paper proposes a pushover analysis method for underground structures and its application in seismic damage ***,three types of force distribution are presented based on ground response ***,the target displacements and analysis models are established according to force-based and performance-based ***,the pushover analysis procedure for underground structures is ***,the applicability of pushover analysis to underground structures is verified by comparing the responses of a Chongwenmen subway station determined by the proposed procedure and by nonlinear response history *** addition,two other points are made:that the inverted triangular distribution of effective earthquake acceleration is more practical than the other two distributions,and that performance-based design is more effective than force-based ***,a cyclic reversal loading pattern based on one cycle of reversal loads as an earthquake event is presented and applied to the seismic damage assessment of underground *** results show that the proposed pushover analysis can be effectively applied to the seismic design and damage assessment of underground structures.

摘要：To develop novel sulfonylurea herbicides, a series of chlorsulfuron derivatives was designed and synthesized through introducing tetrahydrophthalimide substructure taken from protoporphyrinogen IX oxidase（PPO） inhibitors onto the critical 5-position of the classical benzene ring. The structures of title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR spectrometry, mass spectrometry and elemental analysis. In addition, the crystal structure of compound I1-5 was further determined by X-ray diffraction analysis. Bioassay results showed that individual compounds exhibited good herbicidal activities, especially compound I1-8, which displayed 100% inhibition rate against Echinochloa crusgalli at 150 g/ha（1 ha=104 m2） with the method of foliage spray in the pot experiment.

摘要：针对我国尚缺少完善的地铁地下结构抗震分析方法和专门的地铁结构抗震设计规范的现状,在分析目前我国地铁等地下结构抗震研究及设计方法的基础上,重点阐述了需要迫切解决的五个关键问题:合理的地下结构动力分析模型,高效的地下结构-地基系统动力相互作用问题分析方法,合理而实用的地铁地下结构地震破坏模式和抗震性能评估方法,地铁地下结构抗震构造措施,地铁区间隧道穿越地震断层的设计方案及工程措施。这些问题的研究和解决将为地铁地下结构抗震设计规范或规程的制定奠定坚实的基础。

摘要：Since sulfonylurea is one of the most potent acetohydroxyacid synthase（AHAS） inhibitors, a series of novel sulfonylureas containing an oxime ether moiety was designed and synthesized and their chemical structures were determined by means of 1H nuclear magnetic resonance（NMR）, 13C NMR and high-resolution mass spectrometry（HRMS）. In the herbicidal bioassay, several compounds showed moderate to good herbicidal activities against dicotyledons, but their activities against monocotyledons decreased. The in vitro antifungal activity was tested at a dosage of 50 mg/L. And the results show that compounds 71, 7m and 7n exhibit promising antifungal activities against six common plant pathogenic fungi. Further investigations on molecular modification are in progress.

摘要：为得到低强度、低弹性模量,能够在离心机振动台试验中产生破坏现象的模型材料,采用正交试验方法对不同配合比石膏材料进行研究,根据试验结果选出适合土–结构离心机振动台破坏性试验的石膏配合比。并进一步对该配合比石膏进行耐水性研究,结果表明,试验中的防水处理效果显著。对于振动模型试验,相似关系设计是很重要的环节,在试验前期关系到模型尺寸的大小与材料的选取,在试验结束后则关系到试验数据的处理。基于Bockingham定理,采用量纲分析法对土–结构动力相互作用的离心机振动台试验进行模型相似关系设计。在相似设计中,主要考虑要在试验中能够激发出与原型相似的土–结构动力相互作用,因此需要保证土–结构刚度比、结构惯性力满足相似关系。由此,根据相似关系要求,分别得到石膏材料及微粒混凝土材料试验模型结构,并对2种材料模型进行分析。