摘要：The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

摘要：Objective:To investigate the changes in radial pulse induced by thermal stresses(TSs).Methods:Sixty subjects were *** an open-label,2x2 crossover randomization design,both feet of each subject were immersed in 15%:water for cold stress(CS)and in 40 X:water for heat stress(HS)for 5 min *** pulse,respiration and electrocardiogram(ECG)signals were recorded before,during and immediately after the ***:The an alysis of heart rate variability revealed that CS in creased the low-freque ncy(LF)and high-frequency(HF)components(P<0.05)and that HS reduced the LF and HF components(P<0.01).Both TSs reduced the normalized LF,increased the normalized HF,and reduced the LF/HF *** differences in the ECG signals were more dominant during the TS sessions,but those in the radial pulse signals became more domi nant immediately after the TS sessi *** decreased the pulse depth(P<0.01)and in creased the radial augme ntation in dex(P<0.1),and HS in creased the pulse pressure(P<0.1)and sube ndocardial viability ratio(P<0.01).There were no significant differences in pulse rate during the three time sequences of each *** respiration rate was increased(P<0.1),and the pulse rate per respiration(P/R ratio)was significantly decreased(P<0.05)with *** HF region(10-30 Hz)of the pulse spectral density was suppressed during both ***:CS induced vasoconstriction and sympathetic reactions,and HS induced vasodilation and parasympathetic reacti *** on defi nitions used in pulse diag no sis,we made the novel discoveries that the pulse became slower(decreased P/R ratio),more floating and tenser under CS and that the HF region of the spectral power decreased significantly under both TSs.

摘要：对7个方形钢管混凝土梁柱节点进行循环荷载的试验。所有7个构件的连接都采用连接在梁翼缘上的T形加劲肋进行加固。所有构件被分成3个试验系列:第一个是TS系列,构件只被T形加劲肋加固;第二个为TSD系列,除加劲肋之外,还有RBS梁;第三个为TSH系列,在加劲肋上有很多小洞。试验结果主要通过构件的延性来表现。所有构件的塑性转角都超过了0·03 rad,这表明构件的延性能力超出了人们在AISC抗震规定中的特殊弯矩钢连接的要求。锥形的水平加劲连接,翼缘削弱钢梁加工和水平加劲肋在减少水平构件顶端的应力集中方面很有效。然而,在HAZ竖向构件焊接中一些构件的过早失效表明,示设计中T形加劲肋的应变硬化需要被考虑。

摘要：The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.