摘要：In order to enhance the bearing capacity of non-circular gear pair, the non-circular gear pair with double generating angles is proposed based on the design idea of unsymmetrical gear with double pressure angles. The tooth profile is designed by generating cutting theory, the pure rolling mathematic model that the center line of unsymmetrical rack roll along non-circular pitch curve is built, the digital model of non-circular gear with double generating angles is created through the second development method of CAD software, and then the drive characteristic and tooth strength are analyzed. The results show that the design method for double generating angles non-circular gear proposed in this paper is feasible, which is significant to improve the bearing capacity of non-circular gear pair.

摘要：介绍元胞自动机理论和STEPS软件。研究音乐厅人员疏散的设计,运用STEPS软件,分析火灾导致某安全出口失效的情况下音乐厅人员疏散过程,分析其他安全出口的利用率。模拟结果显示,安全出口利用不均衡,人员在疏散楼梯口以及个别直通室外的安全出口发生拥堵。建议增大安全出口宽度,合理分流,统筹疏散;制定完善的管理制度和维护措施。将STEPS模拟结果与Pathfinder模拟结果进行对比,模拟结果基本一致。

摘要：小浪底水库运行后,黄河下游游荡段冲刷剧烈,研究其河床下切特点及影响因素对游荡段河道整治具有重要意义。利用1999-2020年黄河下游游荡段28个淤积断面汛后实测地形数据,计算了游荡段各断面及河段河床累计下切深度及平滩水深,利用水文资料得到了各水文站逐年水位-流量关系曲线,并计算了一定流量下水位的逐年变化。结果表明:(1)1999-2020年黄河下游累计冲刷量达20.5亿m^(3),其中游荡段冲刷量最大,约为14.7亿m^(3)。(2)黄河下游游荡段在2000-2007年期间河床下切最为剧烈,多年平均河床下切深度达0.24 m/a,2008-2020年游荡段河床下切程度有所减弱,多年平均河床下切深度减小至0.05 m/a。(3)各站水位-流量关系发生了较大变化,游荡段各站给定流量下水位下降明显,沿程水文站水位下降存在一定的时间滞后,滞后时间约3~4 a。各站在500 m^(3)/s下的水位下降幅度均大于3 000 m^(3)/s水位下降幅度,其中高村站的下降幅度最大。(4)游荡段平滩水深由1999年的1.6 m逐步增大到2018年的4.0 m,之后又降低至2020年的3.8 m。(5)从来水来沙条件和河床边界条件两方面探讨了影响游荡段河床累计下切深度的因素,发现前期6年平均来沙系数是影响累计平均河床下切深度的关键水沙因子,定量揭示了游荡段持续的河床粗化对河床下切起抑制作用。

摘要：PC104是一种工业计算机总线标准,PC104与国产化CPU(中央处理器)结合实现PC104嵌入式控制模块是一种新的应用需求。针对这种需求对PC104结构以及国产的"龙芯"1A芯片进行研究,从原理上结合二者特点,再利用高密度布局布线方式设计完成了基于PC104的国产嵌入式控制模块。对模块的功能和性能分别进行测试分析可得,模块化方式的嵌入式控制系统和普通嵌入式控制系统在性能和功能上表现一致,更有便于拓展外设功能的优点,而且可直接用于具有抗震加固特性的机箱,比较适用于未来的工业以及军事应用。

摘要：针对热噪声试验中石英灯加热器的快速迭代设计和优化的需求,本文简化了行波管模型和噪声气流的模拟方法,基于蒙特卡罗法和热网格方法建立了热噪声试验系统中圆锥形薄壁结构件的热分析模型,获得了圆锥形薄壁结构件在石英灯加热器辐射下的温度分布,并通过与试验数据的对比分析,验证了计算模型的有效性。本文使用的建模方法和热分析模型可用于热噪声试验中类似结构的温度均匀性评估,为石英灯加热器设计和优化提供支撑。

摘要：Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV（DPP-IV） inhibitors, with natural and non-natural L-amino acids as the starting *** structures were characterized by ~1H NMR,^（13）C NMR and *** target compounds were screened for the DPP-IV inhibition,and the preliminary SAR result was ***, compounds 4c,4d and 4f with good DPP-IV inhibition in vitro were further evaluated through a mouse oral glucose tolerance test （OGTT）.The preliminary result showed the potential value for further studies on those thiomorpholine-bearing compounds as DPP-IV inhibitors.

摘要：陵水17-2气田开发采用带凝析油储存和外输功能的深水半潜式生产储油平台——“深海一号”能源站,为国际上首个采用立柱储油的半潜式生产平台,该平台设计面临环境条件恶劣、建造场地和合龙资源受限、凝析油储存和外输安全性要求高、立管运动要求严格等诸多挑战。本文详细阐述了“深海一号”能源站总体设计技术,包括深水环境条件分析、基于受限场地资源的定制化设计、凝析油U型储存隔离与安全储存和动力定位外输以及整体船型参数设计等,并重点介绍了深水系泊系统设计、深水钢悬链立管布置与疲劳寿命分析、平台低频运动响应预报、关键结构设计及30年不进坞的防腐方案设计等关键技术。基于上述技术,研制出了新型半潜式生产储油平台母型船——“深海一号”能源站。该平台建造完成并投入使用,标志着中国海洋工程制造业逐步向深水浮式生产平台等高端装备业进军,也为同类深水浮式平台的设计提供了借鉴。

摘要：Based on the principles of the bioisosterism, combination of the active substructures of selective estrogen receptor modulators which are currently therapeutic agents available for the prevention and treatment of various estrogen dependent diseases, and structural optimization, a novel series of 2-aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]- chromen derivatives was designed as potent selective estrogen receptor modulators via molecular docking. The target compounds have been synthesized, and characterized by 1R, proton NMR, ESI-MS, elemental analysis and evaluated for their antitumor activity against human osteosarcoma U2OS-EGFP-4FI2G cell line. Some target compounds showed good inhibition effects on U2OS-EGFP-4F12G cell line and the preliminary structure-activity relationships were discussed.

摘要：Biomedical metals are widely used as implant materials in the human or animal body to repair organs and restore function, such as heart valves, meninges, peritoneum and artificial *** element affects the microstructure, mechanical property, corrosion resistance and wear resistance, but also influences the antibacterial and biological ***, antibacterial metal alloys have shown great potential as a new kind of biomedical materials, in which Cu has been widely used as antibacterial agent *** addition, biodegradable metal alloys, including magnesium alloy and zinc alloy, also have attracted much attention *** was also used as alloying element to adjust the degradation ***, the role of Cu in the alloy design will be very important for the development of new *** this paper, we summarized the recent research results on the Cu-containing metal alloy for biomedical application and hoped that this review would give more suggestions for the further development of biomedical metal alloy.

摘要：以发动机整机试验数据为研究对象,建立了一套发动机试车气路故障诊断系统.首先阐述了该系统的设计功能和总体流程逻辑;使用故障模式法和调整模式法建立了气路部件故障诊断和优化调整模块;然后以一个双轴分排涡扇发动机为例,针对气路部件故障诊断和优化调整给出了考虑噪声的数值试验分析.最后就该系统的发展进行了讨论.