摘要：A series of novel 3,4-dichloroisothiazole based 1,2,4-triazole derivatives were rationally designed and synthesized. Their structures were confirmed by IH NMR, 13C NMR, HRMS or elemental analysis; the typical crystal structure was determined by X-ray diffraction for validation. All target compounds were evaluated for their in vitro fungicidal and in vivo anti-TMV activities. The bioassay results indicated that compound 6b, namely 1-（3,4-dichloroisothiazol-5-yo）-o-（4-ouorophenyo）-2-（OH-o,2o4-triazol-o-yl）ethanol, exhibited excellent growth inhibition against B. cinerea, C. arachldico;a and P. piricola with median effective concentrations （EC50） of 6.98, 2.73 and 3.07μg/mL, respectively, and good in vivo anti-TMV activity of over 60% of inactivation and induction activity at 100 μg/mL. These data demonstrate that compound 6b is both a fungicide and an anti-TMV lead, deserving further studies.

摘要：There is a consensus that the prevention of wound infection should be achieved in the following ways:(1)closing the wound to protect it from extra infection;(2)an antibacterial agent that could kill endogenous ***,existing bulk two-dimensional antibacterial materials show inefficient adhesion to wounds with complex morphology and thus cause the prevention of wound *** the thickness of bulk two-dimensional materials to less than 100 nanometres endows them with great flexibility,which could allow them to adhere to wounds with complex morphology by only physical ***,a broad-spectrum and efficient antimicrobial peptide(AMP)was introduced to biocompatible methacrylated gelatine(GelMA)with multiple modification sites,which served as an inner antibacterial *** being combined with a biodegradable and good mechanical poly-l-lactide(PLLA)outer layer through plasma-treatment-assisted spin coating,we finally constructed bilayered antibacterial nanosheets with a thickness of approximately 80 *** bilayered nanosheets possess good adhesion to surfaces with complex topography and thus achieve better wound closure than other bulk two-dimensional ***,this AMP-grafted conjugation shows minimal cytotoxicity compared with Ag^+antibacterial agents,and the antibacterial rate of nanosheets is dependent on the graft rate of *** suggest that this bilayered antibacterial nanosheet might be an advanced anti-infection dressing for wound treatment in clinical settings.

摘要：随着绿色环保概理念日益深入人心以及世界各国对船舶污染物排放标准提高,船舶设计人员正寻求各种方法减少柴油消耗量和排放,油电混合动力船舶结合柴油机推进船和电推船的特点,其在节能减排和降噪方面具有明显优势。文章将并联式油电混合动力系统应用于嘉陵江水域的公务艇,为提升系统转矩合成器的性能,设计中将行星齿轮内置于合成器中,同时将模糊逻辑控制策略对整个动力系统进行控制管理,有效地发挥了系统的效能。计算结果表明,设计船的运行成本和污染物排放量相对同等船型将低了8.6%和10.48%,节能减排效果明显。

摘要：Introduction The concept of“gradients”has been widely demonstrated and applicated in *** example,concentration gradients and potential gradients in the body can regulate the homeostasis as well as the balance of physiological environment;oxygen gradients play a vital role in cellular gene expression and migration.

摘要：针对量化器参数不匹配和外部干扰问题,利用事件触发方法设计了线性不确定系统的量化反馈滑模控制方法。首先,在动态量化机制中考虑了时变量化器灵敏度变化率,提出一种新的离散在线调整策略,并建立了编码器和解码器侧的量化参数的时变比例模型。其次,结合所设计的量化器事件触发机制,证明了所提出的滑模控制律可以有效消除量化器参数失配的影响,实现不确定线性系统的全局鲁棒镇定。再次,分析了帧间时间的下限以确保没有Zeno行为。最后,通过算例验证了理论结果的有效性。

摘要：针对多无人机编队飞行中的僚机故障问题,设计了一种基于观测器的自适应容错控制方法。首先,基于领导跟随法建立了无人机编队模型及僚机故障的编队模型,并将其划分为位置子系统与偏航角子系统。其次,基于观测器技术对位置子系统中的状态和故障进行观测,并结合观测的状态和故障信息构造状态反馈控制律;然后,基于自适应方法给出偏航角子系统的控制设计方案,并用Lyapunov理论证明系统跟踪误差最终有界收敛。通过仿真,本文算法在发生故障后对系统的完全跟踪时间和稳态误差分别比基于鲁棒故障估计的方法最大降低了76%和70.3%,并且均比传统观测器的方法明显减少较大,证明了本文算法能更好的克服偏差故障带来的不利影响,有效实现四旋翼无人机群的编队飞行。

摘要：针对虚假数据注入(FDI)攻击下的信息物理系统(CPS),研究了一种基于滑模和扩张观测器的控制方法.首先对系统进行动态线性化,构造了扩张观测器并对观测误差的收敛条件进行了分析.其次,设计了积分滑模面,通过线性矩阵不等式的形式导出滑动模态系统的渐近稳定判据,求出了系统满足L_2增益性能的滑模向量.接着,基于指数趋近律,提出了用来消除量化误差和广义干扰的自适应积分滑模控制器,以使系统能到达滑模面.该方法估计精度高、响应速度快,对FDI攻击和量化参数失配具有较强的鲁棒性.最后,数值仿真验证了该方法的有效性.

摘要：探讨不同合成方法对改性细菌纤维素/羟基磷灰石复合支架微观结构和性能的影响。采用原位复合法、物理混合法及生物矿化法制备改性细菌纤维素(TBC)与羟基磷灰石(HA)复合多孔支架,利用扫描电镜(SEM)、能谱分析(EDX)、X射线衍射(XRD)、傅里叶红外变换光谱(ATR-FTI)对不同方法合成的产物进行微观结构表征,同时通过力学实验确定不同支架的力学性能参数。SEM和ATR-FTI等结果表明,采用原位复合法、物理混合法及生物矿化法都可以成功地将HA复合在TBC的纳米纤维上,但是复合的机理各不相同。原位复合法中HA纳米颗粒是以螯合键的方式与TBC纳米纤维上的羧基联合,而物理混合和生物矿化法HA纳米颗粒是采用静电吸附的方式复合在TBC纤维上。XRD表明,不同方法合成的支架都出现了明显的(211)峰,但峰的形态有明显的差别。力学测试结果表明,复合后产物的力学性能也有很大的差异,采用原位复合的支架强度最低,复合后支架强度由4.67 MPa迅速减小到1.00 MPa,而用生物矿化复合的支架强度最高,复合后支架强度由4.67 MPa增加到到5.55 MPa。通过对不同方法合成的复合支架微观结构的表征和分析,为骨组织工程支架的设计提供依据。

摘要：对吉安大修升级后首部SC型双偏振天气雷达,按照升级大纲要求进行性能参数测试,主要性能参数测试表明,动态范围、噪声系数、强度定标、径向速度检验、差分参量等主要参数指标均满足设计要求。接收机水平通道和垂直通道的参数指标经测试两通道之间存有一定偏差,这种不确定偏差会引起双偏振差分反射率Z_(DR)、差分相移Φ_(DP)、差分相移率K_(DP)、相关系数PHV等参量的误差,因此每年汛期前及年终需对雷达系统进行定期巡检标定确保业务使用质量。同时详细给出各性能参数具体测试方法及参数特性的分析,为该型号天气雷达在国内升级改造提供一定的科学依据,并结合实际观测降水个例对相关参数进行分析。

摘要：钼及其合金具有优异的高温力学性能,被广泛应用于冶金、机械、化工、航空和核工业等领域。粉末冶金是钼合金的主要制备方法。通过固溶强化、第二相强化、细晶强化等多种强化手段可以提高钼合金的力学性能,从而拓宽钼合金的应用范围。本文介绍了粉末冶金制备钼合金的研究进展,包括粉体制备方法、压制工艺及坯体烧结工艺等,讨论了钼合金的强韧化方法及其机理,并展望了粉末冶金法制备钼合金的发展方向,以期对钼合金的设计和制备提供一些思路。