摘要：Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of ***,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial *** by the hunting behavior of spiders,here,a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of *** virtue of the initiative bacteriacapturing functionality,this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology ***,its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species(ROS)release allows such nanoagent to harvest a promoted bactericidal ***,the woundplast employing the spiderweblike nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available *** work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming.

摘要：Theranostic nanoprobes can potentially integrate imaging and therapeutic capabilities into a single platform,offering a new personalized cancer diagnostic ***,there is a growing concern that their clinical application is not safe,particularly due to metal-containing elements,such as the gadolinium used in magnetic resonance imaging(MRI).We demonstrate for the first time that the photothermal melting of the DNA duplex helix was a reliable and versatile strategy that enables the on-demand degradation of the gadolinium-containing MRI reporter gene from polydopamine(PDA)-based theranostic *** combination of chemotherapy(doxorubicin)and photothermal therapy,which leads to the enhanced anti-tumor *** vivo MRI tracking reveals that renal filtration was able to rapidly clear the free gadolinium-containing MRI reporter from the mice *** results in a decrease in the long-term toxic effect of theranostic MRI *** findings may pave the way to address toxicity issues of the theranostic nanoprobes.

摘要：X射线计算机断层扫描技术(X-ray computed tomography,CT)是目前临床医学诊断中最为重要的工具之一.临床使用的CT造影剂主要是一些有机碘类小分子,但是这类小分子造影能力有限、体内循环时间短,极大地限制了CT成像技术在疾病诊断中的应用.相比之下,CT成像纳米探针不仅极大地提升了造影能力,同时具有更好的生物相容性和更长的体内循环时间.更重要的是,其表面易修饰特性有助于多功能成像探针的构建.本文针对近年来CT成像纳米探针的设计及应用进行了简要介绍,并展望了其未来的发展方向.

摘要：为了解决信号传输和接收过程中多个信号混叠造成信号干扰和损失的问题,设计了一种信号分离装置。该装置主要由模拟信号源产生、信号调理、信号采集与数字处理和信号输出4大模块构成。在信号调理模块中,对基于MCP6002的加法器电路产生的待分离信号源进行直流偏置,将信号变换至STM32G473片内数模转换器(ADC)采集范围。在信号采集与数字处理模块中,采用ADC对调理后的信号进行连续采样,并使用快速傅里叶变换(FFT)对采集到的信号序列进行时频域变换,分析计算两原始信号的类型和频率参数。在信号输出模块,利用DDS模块AD9833输出两原始信号,最后在信号调理模块利用乘法、滤波和比较电路形成信号跟踪反馈,有效抑制漂移。本装置主要考察了两路正弦信号、三角和正弦信号以及两路三角信号的分离,测试结果表明,该装置能准确分离出两信号,且频率的平均精确度达到99%以上,并能稳定显示波形且不产生漂移,提升了信号分离的准确性和有效性。

摘要：： Ｌ Ｂ 膜作为模板可诱导晶体取向成核和外延生长，生成的晶体材料具有独特的微观结构和优异的物理化学性能。这种方法对于生物矿化现象的研究以及新颖材料合成策略的设计等方面具有重要的启示意义。本文从 Ｌ Ｂ 膜诱导晶体取向生长的机理及利用等方面综述了该领域研究的最新进展。

摘要：内陆江域地区地质条件变化复杂,特别是较为发育的软弱夹层对工程设计及施工产生着较大影响。为查明该类型地层展布特征,以赣江流域南昌段为研究对象,采用微动及多道水上地震法,开展江域地区工程地球物理探测应用研究,结果表明,该方法组合能较为准确地探获第四系覆盖层分布特征,特别是对查明淤泥质粘土等地质异常体空间展布特征极为有效,结合钻孔验证、测试结果,能较为准确地获取不同地层物参、动参特征,为工程勘察、设计、施工提供重要依据。