摘要：Objective: This study was undertaken to determine the effect of menopause and hormone replacement therapy (HRT) on incontinence quality of life (I- QOL) score improvement in women with moderate- to- severe stress urinary incontinence (SUI) after nonsurgical, transurethral radiofrequency energy (RF) tissue micro- remodeling. Study design: Retrospective review of prospective, randomized, controlled clinical trial. Women with moderate- to- severe SUI were analyzed by menopausal status and HRT use for 10- point or greater I- QOL score improvement (an increase associated with subjective and objective SUI improvement). Results: RF micro- remodeling resulted in 81% of subjects achieving 10- point or greater I- QOL score improvement versus 49% of sham subjects at 12 months (p = .04). Outcomes did not differ statistically when premenopausal (85% ), postmenopausal using HRT (70% ), and postmenopausal not using HRT (71% ) groups were compared. Conclusion: Menopausal status and HRT demonstrated no impact on the quality of life improvement experienced by women with moderate- to- severe SUI who underwent RF tissue micro- remodeling.