摘要：Oral administration is the best way for the most patients due to the good compliance,and intestinal epithelium is the main barrier of oral drug *** order to overcome the small intestine epithelial barrier to orally deliver water-insoluble drugs,deoxycholic acid(DA),a substrate of the intestinal bile acid transporters,conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)(DA-PEOz-PLA)was designed and synthesized,and deoxycholic acid-modified polymeric micelles composed of DA-PEOz-PLA and mPEG-PLA were fabricated to encapsulate model drug coumarin 6(C6)based on intestinal bile acid *** structure of DA-PEOz-PLA was confirmed using 1 H NMR and TLC,and the molecular weight measured by GPC was 10034 g/mol with a PDI of *** C6-loaded polymeric micelles with drug loading content of 0.085%were characterized to have 40.11 nm in diameter and uniform spherical morphology observed by ***,the deoxycholic acid-modified polymeric micelles were demonstrated to further enhance the transmembrane transport *** mechanic study evidenced that anchorage of deoxycholic acid onto the micelles surface enriched their transcellular transport ***,the designed deoxycholic acid-modified polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

摘要：In order to enhance the targeted delivery of anticancer drugs by polymeric micelles, folic acid(FA), the ligand of folate receptor(FR) over-expressed in the most cancer cells, modified p H-sensitive polymeric micelles were designed and fabricated to encapsulate doxorubicin(DOX) by combination of p H-sensitive amphiphilic polymer poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) with FA-conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide). The prepared micelles were characterized to have about 36 nm in diameter with narrow distribution, well-defined spherical shape observed under TEM and p H-responsive drug release behavior. Moreover, the tumor targeting ability of the FA-modified p H-sensitive polymeric micelles was demonstrated by the cellular uptake, in vitro cytotoxicity to FR-positive KB cells and in vivo real time near-infrared fluorescence imaging in KB tumor-bearing nude mice. The efficient drug delivery by the micelles was ascribed to the synergistic effects of FR-mediated targeting and p H-triggered drug release. In conclusion, the designed FR-targeted p H-sensitive polymeric micelles might be of great potential in tumor targeted delivery of water-insoluble anticancer drugs.

摘要：To overcome the main barrier of intestinal epithelium for the oral absorption of poorly water-soluble drugs and further improve their oral absorption, Gly-Sar, the substrate of the oligopeptide transporter PepT1 widely distributed in the small intestine,conjugated poly(ethylene glycol)-block-poly(D,L-lactide)(Gly-Sar-PEG-b-PLA) was designed and synthesized, and Pep T1-targeted polymeric micelles were prepared and characterized. The structure of the synthesized Gly-Sar-PEG-b-PLA was confirmed by use of TLC and 1 H-NMR. The average molecular weight measured by GPC was 5954 g/mol with PDI of 1.34. The DiI-loaded polymeric micelles from Gly-Sar-PEG-b-PLA with drug loading content of 0.076% were characterized to exhibit 40.36 nm in diameter with PDI of 0.294, and well-defined spherical shape observed by TEM. Furthermore, the PepT1-targeted polymeric micelles profoundly enhanced intestinal absorption of poorly water-soluble drug. Therefore, the designed PepT1-targeted polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

摘要：蒸馏操作是化工生产中重要的单元操作。目前,职业教育的学生具有逻辑思维能力不够、学习兴趣不高、注意力容易分散等不良特点。蒸馏的教材、教学仍然是直接引入式和逻辑性强的方法进行,不符合学生的学习特点。本论文采用以学生自主学习为主,讲做结合,步步引导,层层深入的思路来进行教学设计,学生掌握了蒸馏过程、理解了蒸馏原理,学会了用自主学习的方法解决问题,主动思索掌握新知识。

摘要：针对激光引信常用的恒比定时时刻鉴别法的饱和漂移误差问题,提出了一种前沿判别与恒比定时复合的时刻鉴别方法及其误差补偿模型。建立了恒比定时时刻鉴别的漂移误差模型,分析了饱和漂移误差随回波信号理论峰值电压的变化规律;提出了基于复合时刻鉴别法的漂移误差补偿方法,建立了复合时刻鉴别的漂移误差补偿数学模型,得到了修正的脉冲激光测距公式,并进行了测距精度验证实验。结果表明,复合时刻鉴别及误差补偿修正方法可有效减小系统误差,测距精度可控制在±0.3 m以内。

摘要：为了精确分析双吸泵作液力透平叶轮内的非定常流动特性,采用SST k-ω湍流模型在设计工况下进行数值模拟。对一个周期的非定常速度场进行动态模态分解(DMD),并结合Q准则,得到前4阶主要模态及其相应的时空信息。分析结果表明:DMD方法将叶轮内复杂的流场特征分解为动静干扰模态、基本模态和耗散模态。其中动静干扰模态占主导地位,频率为叶轮旋转频率,反映出叶轮内流动受静止部件干扰的流动特征,涡结构主要为点状涡和不连续的管状涡;基本模态频率为0Hz,反映出叶片流道几何特征引起的稳态流场特征,涡结构主要为连续的管状涡;3阶及4阶模态为耗散模态,反映出叶轮内流动受静止部件干扰,在叶片上产生的流动分离及不稳定涡结构脱落的特征,以片状涡和不连续的管状涡为主。在特定频率下DMD方法可以对叶轮流场结构进行分解,能够清楚地分析双吸泵作液力透平叶轮内复杂流场的非定常特性。

摘要：为提高企业的对外形象,改善企业的生产环境,针对厂区地形多样化的特点,结合企业文化和工厂自身现状确定绿地设计风格,突出以人为本、生态园林景观的设计理念。将甘肃博原生物科技有限责任公司厂区分A、B、C 3个区,采用自然式、规则式、混合式园林风格进行设计,在景观设计中融入企业文化思想及"力存久远,做大做强"的企业愿景,布局合理、定位科学、设计手法多样。绿地设计中注重植物配置的生态性,本着适地适树原则,充分利用植物的观赏性,创造丰富优美景观,强调乡土树种的应用,景观层次丰富,具有地域特色。

摘要：中原文旅城欢乐世界一期雪世界高区结构体系采用巨型钢框架,存在结构扭转不规则、楼板缺失、大悬挑、竖向构件间断及钢桁架平台为重载大跨钢结构等不规则情况和设计难点。设计中采用基于性能的抗震设计方法,根据构件的重要程度采用不同的性能目标。4个巨型框架柱为支撑框架结构,其支撑采用屈曲约束支撑,使结构在大震作用下形成良好的屈服机制和耗能能力。对结构进行小震反应谱法弹性分析、弹性时程分析、中震弹性分析以及大震弹塑性分析。结果表明,结构整体和构件的抗震性能均能达到设计的预期目标;巨型钢框架结构体系较好地适应了本工程的实际情况,可供类似项目在选择结构体系时参考。

摘要：萘二酰亚胺(NDI)类化合物由于其较好的平面性和较强的接受电子能力,被广泛应用于有机场效应晶体管(OFETs)和有机太阳能电池中(OSCs)。然而,高迁移率的n型和双极性NDI类半导体材料较少。基于此,本文设计合成了核位硒杂环修饰的NDI衍生物,通过引入1,2-二硒苯和1,2-二硒萘基团,对其能级进行了有效的调控,获得了两个新型的窄带隙NDI衍生物。通过溶液旋涂法,制备了两种材料的底栅底接触场效应晶体管器件,二者在空气中都表现出n型半导体特性,退火温度为120℃时性能达到最优,分别为1×10^(-3)cm^(2)·V^(-1)·s^(-1)(4)和5×10^(-3)cm^(2)·V^(-1)·s^(-1)(5)。同时,通过原子力显微镜和X射线衍射对材料薄膜的退火过程进行了研究。

摘要：在PPP项目融资过程中考虑异质投资者的加入有助于实现资本组成的多样性。因此,有必要构建影响PPP项目投资者异质性的指标体系,为实现PPP项目的风险分散奠定基础。首先,基于文献分析及专家深度访谈,提出了12项构成PPP项目投资者异质性的指标;接着,利用AHP-DEMATEL方法计算了各指标综合权重,结合云模型理论进行了PPP项目投资者异质性指标的定性与定量特征转换;最后,基于案例分析,运用云模型理论确定了项目投资者的异质性指标云评价等级。研究结果表明异质企业性质、异质投资比例、异质风险态度、异质资金来源、异质预期投资期限是对该项目影响程度较高的异质性指标,对其进行了相应原因分析与讨论,在设计项目风险分散机制时应重点关注这些指标。