摘要：高催化活性的催化材料是提升铝-空气电池阴极氧还原反应(ORR)的必要条件,设计并制备了石墨烯基钙钛矿型催化材料,测试了其电化学性能并组装了铝-空气电池,借助第一性原理研究了催化作用机理。通过科研问题设计和合作研究实践完成基于科研驱动的PBL教学模式实践。结果表明:溶胶-凝胶法制备的掺杂钙钛矿与石墨烯负载,可有效提高导电性和电催化活性,保持电池高稳定放电。该实验从材料制备、电池组装、电子结构分析等方面设计和调控催化性能,使学生掌握了材料制备基本实验技能和电池测试综合应用能力,并引入了材料设计创新性研究成果,实现从理论到实践再到理论的飞跃。PBL教学激发了学生创意意识和科研兴趣,提高了团队合作和综合能力。

摘要：Beta-ketoacyl-acyl-carrier-protein synthase Ⅱ,an important enzyme in biosynthesis of bacterial fatty acid,is an attractive target in antibacterial drug design. Platensimycin(PTM), produced by Streptomyces platensis, has a strong, broad-spectrum Gram-positive antibacterial activity by selectively targeting to Fab F but exhibits no inhibition to the Fab F from Streptomyces platensis(spFabF). To study the self-resistance mechanism within the PTM-producing strain and provide hint for development of novel antibiotics, it is imperative to solve the structure of spFabF and elucidate the difference between spFabF and other Fab Fs which are not resistant to PTM. To this end, we constructed four chimeric Fab Fs based on the sequence of spFabF and its homologous protein after the expression of wide-type spFabF was failed. The crystal structure of one chimera, js_(200)FabF, of 91.2% sequence identity to spFabF,was solved. A structure comparison of js_(200)FabF with a PTM-bound Fab F suggested that three loops nearby the catalytic site might play key roles in preventing the binding of PTM to spFabF. The results provide an encouraging basis for further studies on the self-resistance mechanismand structure-based design of novel antibiotics targeting FabFs.

摘要：针对当前蚕蛹雌雄鉴别环节人工劳动强度大、蚕蛹雌雄识别分选装置准确率和效率不高、适用品种范围小等问题,根据雌雄蚕蛹性腺特征差异是区别不同品种蚕蛹雌雄的可靠依据,该研究设计了一种蚕蛹性腺图像在线采集与雌雄自动识别分选装置。首先,在对蚕蛹基本物理特性参数大量统计的基础上,对振动排序上料机、蚕蛹输送滑轨和蚕蛹翻转拍照装置进行了结构设计与理论分析。在识别方法和计算机硬件条件不变基础上,对装置中蚕蛹排序输送螺旋倾角、滑轨倾角和转动棒带动蚕蛹旋转转速进行了优化设计,以提高装置的识别分选速度。并设计了以SIEMENS-S7-200SMART-ST30为控制器,基于激光、光电传感器检测的信息融合控制系统。分选装置工作性能优化结果为:螺旋倾角为15.62°,滑轨倾角为31.77°,转速为21.09 r/min,单粒蚕蛹平均分选时间为5.13 s,准确率为95.97%,破损率为0.07%。样机试验结果表明,在最优参数下,利用卷积神经网络的全新轻量级雌雄识别分类模型,单粒蚕蛹平均分选时间为5.03 s,分选准确率为96.47%,破损率为0.09%,满足蚕蛹雌雄识别分选实际应用要求。该蚕蛹性腺图像在线采集与雌雄自动识别分选装置能够实现蚕蛹自动排序上料、蚕蛹带性腺图像在线采集、自动识别与雌雄自动分选的一体化,提高了蚕蛹雌雄自动识别分选的效率和准确率。研究结果可为雌雄蚕蛹自动识别分选装置的研发提供理论依据和技术支持。

摘要：本文分析湘南民间艺术老艺人技艺的现状,探讨其数字化传承途径。调研湘南民间老艺人和技艺传承现状,借鉴国内民间艺术保护传承经验,分析民间老艺人技艺数字化的传承与传播路径,以赓续工匠精神中的湘南民间艺术老艺人技艺数字传承,谋求融合发展。在继承中发扬,在传承中创新,既是对国家政策的响应与践行,又是新时代高校师生的使命与担当。

摘要：为保障复杂地质环境中铁路桥梁桩基础的结构安全,进一步提升设计质量,提出一种通用的复杂特殊地质条件下桩基计算方法。选择静水、负摩阻力、膨胀土和地震液化土作为4种基本特殊地质,以桥梁桩基设计规范中的m法和单桩承载力计算式为基础,提出它们各自分别作用时的计算方法和综合作用时的耦合效应算法。结果表明:季节冻结深度线、多年冻土上限深度线、中性点深度线和急剧层深度线可作为冰、液态水、冻土、负摩阻力、膨胀土的分界线;该方法在规范基础上增加的计算步骤、计算参数和外载增量可以移植到桩基通用设计程序中,并适用于任意复杂特殊地质条件计算,可为实现该条件下铁路桥梁桩基安全、高效、精细化的计算提供支持。研究成果应用于铁路桥梁设计中,节省桩长约5%、桩身配筋约4%。

摘要：针对一类参数不确定连续时间系统,本文提出一种具有预见补偿的重复控制器.首先,引入重复控制器,采用预见控制理论中误差系统的方法,构造出包含未来目标值信号信息的扩大误差系统,将原系统的预见重复控制问题转化为扩大误差系统的反馈控制问题;然后,针对扩大误差系统,利用Lyaounov方法和线性矩阵不等式技巧给出闭环系统渐近稳定的条件.并基于此,设计预见重复控制器.最后,数值仿真表明本文结果的有效性.

摘要：从理论、关键技术,具体架构设计等层面研究了云边协同与区块链的融合应用。云边协同与区块链融合架构研究与设计包括了总体融合应用研究与设计、云边协同与区块链交互应用设计、基于云边协同的区块链管理功能设计、基于云边协同的智能合约管理设计、基于云边协同的区块链数据管理设计。通过研究云边协同与区块链融合的可行性和优势,设计出两者互相融合的通用性架构,该架构可以应用于智慧用电、智能网联汽车、智慧管网、工业物联网等应用场景。

摘要：Background： Despite the rapid growth in the incidence of acute myocardial infarction （AMI） in China, there is limited information about patients＇ experiences after AMI hospitalization, especially on long-tern1 adverse events and patient-reported outcomes （PROs）. Methods： The China Patient-centered Evaluative Assessment of Cardiac Events （PEACE）-Prospective AMI Study will enroll 4000 consecutive AM I patients from 53 diverse hospitals across China and follow them longitudinally for 12 months to docunlent their treatment, recovery, and outcomes. Details of patients＇ medical history, treatment, and in-hospital outcomes are abstracted from medical charts. Comprehensive baseline interviews are being conducted to characterize patient demographics, risk factors, presentation, and healthcare utilization. As part of these interviews, validated instruments are administered to measure PROs, including quality of life, symptoms, mood, cognition, and sexual activity. Follow-up interviews, measuring PROs, medication adherence, risk factor control, and collecting hospitalization events are conducted at 1, 6, and 12 months after discharge. Supporting documents for potential outcomes are collected for adjudication by clinicians at the National Coordinating Center. Blood and urine samples are also obtained at baseline, 1 - and 12-month follow-up. In addition, we are conducting a survey of participating hospitals to characterize their organizational characteristics. Conclusion： The China PEACE-Prospective AMI study will be uniquely positioned to generate new information regarding patient＇s experiences and outcomes alter AMI in China and seiwe as a foundation for quality improveinent activities.

摘要：The influence of brazing temperature and brazing time on the microstructure and shear strength ofγ-TiAl/GH536 joints brazed with Ti-Zr-Cu-Ni-Fe-Co-Mo filler was investigated using SEM,EDS,XRD and universal testing *** show that all the brazed joints mainly consist of four reaction layers regardless of the brazing temperature and brazing *** thickness of the brazed seam and the average shear strength of the joint increase firstly and then decrease with brazing temperature in the range of 1090-1170℃and brazing time varying from 0 to 20 *** maximum shear strength of 262 MPa is obtained at 1150℃for 10 *** brittle Al3NiTi2 and TiNi3 intermetallics are the main controlling factors for the crack generation and deterioration of joint *** fracture surface is characterized as typical cleavage fracture and it mainly consists of massive brittle Al3NiTi2 intermetallics.

摘要：本文以上海市民办桃李园实验学校的实践为基础,整体分析了学校教育生态变革中教师参与的内涵、价值,在对教师参与学校良好教育生态建构中关键问题的把握基础上,从“以共同价值理念激发教师参与教育生态变革的意识,以深度协同教研培育教师参与教育生态变革的素养,以教学改革实践搭建教师参与教育生态变革的平台,以和谐关系打造建构教师参与教育生态变革的支撑”等维度设计了引导教师有效参与学校教育生态变革的实践路径。