摘要：This paper is concerned with the robust reliable memory controller design for a class of fuzzy uncertain systems with timevarying delay. The system under consideration is more general than those in other existent works. The controller, which is dependent on the magnitudes and derivative of the delay, is proposed in terms of linear matrix inequality （LMI）. The closed-loop system is asymptotically stable for all admissible uncertainties as well as actuator faults. A numerical example is presented for illustration.

摘要：阿基米德螺旋叶片式水力发电设备是一种新型的低水头微型水力发电装置。介绍了该装置的结构和参数;给出了不同的安装方式和对应结构上的差异,并分别简要说明适用的场合以及能量转化的原理;与传统微型水轮机对比,分析了该装置的主要优势特征;简要概括了目前水力设计与优化方面的研究,总结出水力设计的理论和方法还有待研究和完善;并在设计理论和方法、研究方法以及我国的潜在市场等方面作出了展望。

摘要：Plastic forming is one of enabling and fundamental technologies in advanced manufacturing chains. Design optimization is a critical way to improve the performance of the forming system, exploit the advantages of high productivity, high product quality, low production cost and short time to market and develop precise, accurate, green, and intelligent(smart) plastic forming technology. However, plastic forming is quite complicated, relating to multi-physics field coupling,multi-factor influence, multi-defect constraint, and triple nonlinear, etc., and the design optimization for plastic forming involves multi-objective, multi-parameter, multi-constraint, nonlinear,high-dimensionality, non-continuity, time-varying, and uncertainty, etc. Therefore, how to achieve accurate and efficient design optimization of products, equipment, tools/dies, and processing as well as materials characterization has always been the research frontier and focus in the field of engineering and manufacturing. In recent years, with the rapid development of computing science, data science and internet of things(Io T), the theories and technologies of design optimization have attracted more and more attention, and developed rapidly in forming process. Accordingly, this paper first introduced the framework of design optimization for plastic forming. Then, focusing on the key problems of design optimization, such as numerical model and optimization algorithm,this paper summarized the research progress on the development and application of the theories and technologies about design optimization in forming process, including deterministic and uncertain optimization. Moreover, the applicability of various modeling methods and optimization algorithms was elaborated in solving the design optimization problems of plastic forming. Finally, considering the development trends of forming technology, this paper discusses some challenges of design optimization that may need to be solved and faced in forming pr

摘要：背景与目的:B细胞特异性的莫洛尼白血病毒插入位点1(B-cell-specific Moloney leukemia virus insertion site 1,BMI-1)期在放疗后DNA损伤中发挥重要作用。该研究采用siRNA干扰技术降低食管癌TE13细胞中BMI-1基因表达,探讨BMI-1的表达对X射线照射后食管癌细胞放射敏感性的影响。方法:针对BMI-1 mRNA序列,3对有效的干扰序列(siRNA1、siRNA2和siRNA3)和阴性对照序列由公司设计合成,瞬时转染食管癌TE13细胞,命名为BMI-1 siRNA1、BMI-1 siRNA2和BMI-1 siRNA3共3组,转染阴性对照序列组命名为NC组,未转染组命名为对照组。采用反转录聚合酶链反应(reverse transcription polymerase chain reaction,RT-PCR)和蛋白[质]印迹法(Western blot)检测TE13各组中BMI-1在mRNA和蛋白水平的表达。采用MTT法检测BMI-1基因转染对TE13细胞增殖能力的影响。克隆形成实验检测BMI-1对TE13放射敏感性的作用。流式细胞术测定siRNA干扰BMI-1基因对细胞周期和凋亡分布的影响。RT-PCR和Western blot检测细胞内p16、CDK4基因和蛋白表达水平。结果:3对干扰序列使人BMI-1基因在mRNA和蛋白表达水平低于对照组和NC组,尤以siRNA3组效果最明显。选择siRNA3作为干扰组进行MTT和流式细胞术。MTT结果表明,BMI-1 siRNA3转染后BMI-1的低表达对细胞的增殖能力无明显影响;克隆形成实验的结果显示,空白对照组、NC组、干扰组的D_0分别为2.514、2.506和1.761 Gy;D_q值分别为2.694、2.664和2.122 Gy;外推数N值分别为2.920、2.895和3.336;SF2值分别为0.826 8、0.823 1和0.625 5,可见对照组和空载组间放射敏感性差异无统计学意义(P>0.05),而干扰组细胞的放射敏感性高于对照组和NC组;流式细胞术分析显示,6 Gy照射后,BMI-1 siRNA组G_0/G_1期比例明显高于对照组和空载组,G_2/M期显著低于对照组和NC组,而未照射时BMI-1的低表达对细胞周期无明显影响。干扰BMI-1基因后TE13细胞p16基因和蛋白水平升高(P<0.01),CDK4基因和蛋白表达水平显著降低(P<0.01)。结论:siRNA干扰技术有效地抑制了食管癌细胞TE13中BMI-1基因的表达,联合X线照射后显著消除了细胞周期在G_2/M期的阻滞,增加了食管癌的放射敏感性,其诱导作用与p16和CDK4基因和蛋白表达有关。

摘要：目的:设计一种结构简单、成本较低、灵敏度高的血液透析穿刺点漏血监测装置。方法:该装置包括带体部分和监测部分。带体部分由弹力绷带制作而成,其一端与监测装置连接,另一端游离,并设有魔术贴粘合装置;监测部分包括监测盒和监测元件。结果:该装置操作简便,不影响患者治疗,能够随时监测到穿刺点渗血的情况,解决了患者在透析过程中漏血的安全隐患。结论:该装置在患者透析过程中发挥了较大作用,有效地避免了漏血不良事件的发生,减轻了护士的工作量。

摘要：水文情势是水生态环境质量的重要参考依据,研究湖泊、河流等水文情势变化特征可为水域安全管理和生态系统功能恢复提供一定科学依据。利用城陵矶等代表性站点水文数据以及Landsat5、8卫星遥感数据,综合分析了2000—2020年洞庭湖水文情势变化特征,并从流域层面分析了来水对洞庭湖水文情势变化的驱动影响。结果表明:(1)洞庭湖整体平均水位年际波动较大,同时年内水位变化趋势较为明显,具有明显的丰枯水期;(2)洞庭湖最大水域面积减少,但最小水域面积增加;(3)洞庭湖水体有效连通性大幅度下降,W-E方向的连通性提高,而N-S方向的连通性下降;(4)三口(藕池口、松滋口、太平口)水位和流量变化与湖区整体水文情势关系更加密切,其中藕池口对湖区水文情势影响最大。

摘要：The fore claws of the nymph of Cryptotympana atrata have excellent ability to cut and dig soil. Inspired by this, we designed a biomimetic stubble cutter to reduce the cutting resistance. Reverse engineering and 3D print technology were applied to design the biomimetic stubble cutter. Two types of biomimetic corn stubble cutters with different tooth heights （5 mm and 2.5 mm） were designed. The cutting ability of biomimetic corn stubble cutters was compared to the conventional design by the quadratic regression orthogonal test. Tooth height, dip angle of cutting edge, and cutting velocity were chosen as orthogonal test factors. The biomimetic stubble cutters show lower cutting resistance than the conventional one. Cutting velocity exerts the least effect on cutting resistance, followed by tooth height and dip angle of cutting edge. Optimal combination with the least cutting resistance is tooth height of 2.5 mm and dip angle of cutting edge of 40° while the cutting resistance does not vary remarkably with cutting velocity. Test results indicate the serrated structure design as a principal factor for cutting resistance reduction. The biomimetic stubble cutter design, inspired by the soil-cutting mechanism of Cryptotympana atrata nymph, remarkably improves the performance of stubble cutter.

摘要：针对现有的图像去雨算法通常需要设计先验知识和多阶段优化框架导致算法适应场景单一的问题,提出一种基于图像过滤统一去除雨线和雨滴的去雨核预测网络(RKPN)。有雨图像通过RKPN估计像素级去雨内核。采用空洞卷积提取多尺度特征,提出一个多分支特征聚合模块。通过数据增强构建一个雨线和雨滴混合数据集(RDRS),提升现实世界复杂场景中图像去雨算法的效果。对4个公开数据集和RDRS数据集的广泛实验结果表明,所提模型取得均高于MPRNet等主流网络的峰值信噪比和结构相似度。

摘要：结合雄安设计中心、上海临港游客中心、大河文明馆、海口职工活动中心等一系列实践项目,论述建筑师在绿色设计的过程中,如何从项目所处的环境入手获得最适宜的绿色控制要素,生成总体的调控和平衡策略,并通过项目后评估检测数据的验证,形成主动应对环境、资源、使用者的有效绿色建筑设计策略。

摘要：We propose the construction of a compact linac as the injector of a cancer therapy facility at the Institute of Modern Physics(IMP) of the Chinese Academy of Sciences(CAS). Based on a traditional setup, a new compact fast-bunching design is first introduced to optimize the 600 keV/u RFQ with a 0.05 pm A ^(12)C^(4+) beam. This shortens the RFQ structure length from the standard design value of272–230 cm while effectively regulating the particle loss and emittance growth. In addition, a detailed error analysis was performed after the optimization process. The error sources cover input beam parameters errors, machining errors and alignment errors. The simulation results show that the beam loss and emittance growth of the RFQ are acceptable and within typical ranges of error.