摘要：In coastal areas with complicated flow movement, deposition and scour readily occur in submarine excavation projects. In this study, a smallscale model, with a high resolution in the vertical direction, was used to simulate the tidal current around a submarine excavation project. The finite volume method was used to solve Navier-Stokes equations and the Reynolds stress transport equation, and the entire process of the tidal current was simulated with unstructured meshes, generated in the irregular shape area, and structured meshes, generated in other water *** meshes near the bottom and free surface were densified with a minimum layer thickness of 0.05 m. The volume of fluid method was used to track the free surface, the volume fraction of cells on the upstream boundary was obtained from the volume fraction of adjacent cells, and that on the downstream boundary was determined by the water level process. The numerical results agree with the observed data, and some conclusions can be drawn: after the foundation trench excavation, the flow velocity decreases quite a bit through the foundation trench, with reverse flow occurring on the lee slope in the foundation trench; the swirling flow impedes inflow, leading to the occurrence of dammed water above the foundation trench; the turbulent motion is stronger during ebbing than in other tidal stages, the range with the maximum value of turbulent viscosity, occurring on the south side of the foundation trench at maximum ebbing, is greater than those in other tidal stages in a tidal cycle, and the maximum value of Reynolds shear stress occurs on the south side of the foundation trench at maximum ebbing in a tidal cycle. The numerical calculation method shows a strong performance in simulation of the hydrodynamic characteristics of tidal currents in the foundation trench, providing a basis for submarine engineering construction in coastal areas.

摘要：本文考虑实际环境中风能方向集中的特性,提出一种偏心型半潜式基础,采用AQWA-Fast软件建立风机全耦合分析模型,对比分析对称型风机和偏心型风机在不同风浪入射角下的运动响应特性。结果表明:波浪入射角变化几乎不影响漂浮式风机平均运动响应值和平均发电功率;当风浪入射角相同时,偏心型平台横荡、横摇和艏摇自由度运动性能更优,并在一定程度上降低了系泊张力;当波浪入射角不断变化时,偏心型设计将改善横荡、横摇、纵摇和艏摇运动性能;此外,偏心型风机综合发电性能更好。

摘要：目的 研究中国成人受试者体内不同CYP2C19基因型对奥美拉唑镁肠溶片药代动力学影响。方法 招募32例中国健康成人受试者空腹单次服用奥美拉唑镁肠溶片参比制剂并进行基因检测，采用单中心、随机、开放、单剂量、两制剂、四周期、两序列完全重复交叉设计，受试者口服受试制剂20mg或参比制剂20 mg,抽取空腹组血样至给药后14h。用超高效液相色谱-串联质谱（UPLC-MS/MS）法测定血样中奥美拉唑镁的浓度，并采用Phoenix WinNonlin 8.2统计软件，以非房室模型（NCA模块）计算奥美拉唑镁主要PK参数并评价不同CYP2C19基因对于药物代谢的影响。结果 服用受试制剂正常代谢组、中间代谢组、慢代谢组的Cmax和AUC0-t分别为（286.2±75.7）μg/L,（511.9±198.5）μg·h/L;（542.8±123.6）μg/L,（1075.58±476.21）μg·h/L;（1209.1±165.6）μg/L,（4539.83±1064.55）μg·h/L;3组间差异均存在显著性（P<0.05）。服用参比制剂空腹条件下，正常代谢组、中间代谢组、慢代谢组的Cmax和AUC0-t分别为（264.1±84.7）μg/L,（545.11±229.8）μg·h/L;（538.7±183.1）μg/L,（1110.66±826.33）μg·h/L;（1234.4±182.1）μg/L,（4308.98±1500.34）μg·h/L;3组间差异均存在显著性（P<0.05）。两制剂主要药动学参数(Cmax、AUC0-t、AUC0-∞)的几何均值比90%置信区间均落于80.00%～125.00%。结论 不同个体内CYP2C19基因存在差异，从而导致CYP2C19酶活性的不同，并会影响奥美拉唑镁肠溶片在人体内的血药浓度以及药动学过程。

摘要：A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

摘要：研究了空天飞行器的再入制导预测律的设计问题。根据飞行器再入飞行所受的约束条件确定再入参考轨迹,设计非线性预测控制控制律使得飞行器跟踪参考轨迹,通过在性能指标中加入末端项,以及基于末端项设计局部非线性控制律来保证非线性预测控制律的稳定性。最后给出的仿真实例表明了本文所设计的控制律具有较好的跟踪性能。

摘要：基于轨迹线性化控制方法(TLC)以及径向基神经网络(RBFNN)技术研究了一种新的鲁棒自适应轨迹线性化控制方案并应用于空天飞行器(ASV)飞行控制系统设计中.首先基于被控对象的分析模型设计系统的TLC控制器,然后利用RBFNN对系统不确定的逼近能力,设计了鲁棒自适应控制器及参数的自适应调节律,并采用Lyapunov方法严格证明了闭环系统所有误差信号一致最终有界.最后应用新控制方案设计了ASV飞行控制系统,仿真结果表明了方法的有效性.

摘要：针对一类多输入多输出非线性不确定系统,提出了基于模糊干扰观测器(FDO)的轨迹线性化控制(TLC)方法并应用于空天飞行器(ASV)飞行控制系统设计。利用模糊系统具有以任意精度逼近非线性函数的能力设计FDO对未知干扰和不确定进行估计,并通过鲁棒控制项来提高系统的性能。采用Lyapunov方法本文证明了闭环系统跟踪误差和干扰观测误差一致最终有界。最后利用所提出的控制方案设计了ASV飞行控制系统,仿真结果表明了控制方案的有效性和鲁棒性。

摘要：针对目前用于原子力显微镜的扫描定位平台带宽低、行程小、耦合性能差等问题,提出了一种基于柔性梁的高带宽两自由度精密定位平台并对该平台进行了优化设计、仿真验证与实验分析。首先,提出了以双端固定梁与平行杂交梁为基础的并联柔顺平台,分别运用卡式第二定理和拉格朗日方程建立了平台刚度和固有频率的数学模型;然后,通过最优化理论获取了平台的最高固有频率及最优设计尺寸,并运用有限元方法验证了优化结果的可靠性;最后,搭建了实验系统,对平台进行了实验研究。实验结果表明:所设计平台的最大行程为12.950μm×13.517μm,耦合误差小于1.77%,X,Y方向的固有频率分别为12.21和13.50 kHz,在开环条件下可良好地追踪频率小于1 kHz的三角波,有效改善了传统扫描定位平台响应慢、行程小、耦合性能差等问题。

摘要：Aiming at the geometrical features of different containment relationships in Rapid Prototyping （RP）, a general method of achieving the RP layer＇s cusp distribution of the positive, negative and mixed tolerance is proposed to meet the part＇s different applications. The procedure is executed by projecting the current and the next section of the CAD model onto a horizontal plane, computing the union and the intersection of the sections to get the outer and the inner boundary, and then blending the boundaries using a rotary vector through a proper inner point in the intersection to achieve the current layer＇s scanning contour. The method can realize the layer＇s cusp distribution of the mixed tolerance with unequal cusp height, expanding the connotation of the mixed tolerance.

摘要：针对船用高压比大流量增压器涡轮的多场耦合问题,综合考虑学科间耦合、相互影响,利用反距离加权平均插值函数实现气压、温度到结构域的传递,网格重生成技术实现结构变形向气动分析模型的传递,建立了考虑气动、传热、强度、振动几个学科的增压器涡轮多学科可行(MDF)分析模型,在优化算法的驱动下实现了多学科设计优化。在MDF分析模型中,经过3次迭代实现了耦合系统的求解;在优化过程中,针对造型参数众多所导致优化设计规模巨大的问题,开展造型参数的主效应分析,选取对性能影响的主要参数作为设计变量,以加权平均方法权衡各个学科之间的矛盾,实现增压器涡轮综合性能的提高。