摘要：The encapsulation of essential oil components in cyclodextrins(CDs)to form inclusion complexes(ICs)is an effective strategy for improving their stability and *** aim of the present study was to obtain a deeper understanding of the encapsulation behavior of multi-components inβ-*** molecules ofα-pinene,myrcene,and 3-carene,having the same molecular weight,formed ICs withβ-CD by a freeze-drying method.A simplex lattice mixture design with 28 experiments was carried *** analysis was applied to analyze the encapsulation behavior of guest components,and quantitative models of guest components in ICs were constructed by coupling with near-infrared(NIR)spectroscopy and chemometrics ***,the molecular docking technique was used to obtain the optimal conformation and explain the binding behavior of *** results suggested that the spatial structure and ratio of guest molecules were the key factors affecting the encapsulation effect.A non-destructive and rapid NIR analytical model for the guest component in ICs could be obtained by second derivative(2nd der)***,the encapsulation of guest components inβ-CD was differentiated,and NIR could be used as a rapid and non-destructive tool for quantitative analysis of ICs.

摘要：采用中心复合设计优化了影响多孔型核壳复合颗粒(PCPs)直接压片(DC)性能的配方参数。分别以PVP和NH4HCO3作为壳层材料和制孔剂,选择共喷雾干燥为制备工艺。以PCPs的产率、流动性、压缩性和崩解时间作为响应值。结果表明,NH4HCO3和PVPK30的最佳配比分别为4.76%和9.42%。产率、流动性、压缩性和崩解时间的测定值分别为62.00%、38.50°、4.02 MPa和14.33 min。预测误差分别为2.99%、1.09%、5.70%和2.28%。在本研究中,最优的PCPs与四种DC辅料混合用于连续DC。结果表明,优化后的PCPs具有优良的直压性能和适用性,为其他中药制备PCPs及实现DC提供思路和理论支持。