摘要：Objec.ive: The aim of this study was to determine whether c.rc.lating HLA-G levels, early in pregnanc., predic. the subsequent development of preec.ampsia (PE). Study design: Plasma samples, c.llec.ed longitudinally during the first, sec.nd, and third trimesters, from 12 PE patients and 12 matc.ed c.ntrol patients were tested for HLA-G protein using a validated sandwic. ELISA. Results: First and sec.nd trimester HLA-G levels in PE were signific.ntly lower than in c.ntrol patients (first trimester, 1.25 μ g/mL vs 1.95 μ g/mL, P = .029; sec.nd trimester, 1.11 μ g/mL vs 1.90 μ g/mL, P = .024). c.nc.usion: Our results indic.te that HLA-G levels in plasma from women who subsequently develop PE are lower than c.ntrol patients, as early as the first trimester. This suggests that determination of c.rc.lating HLA-G protein c.nc.ntration may be useful as an early predic.or for the development of PE.