摘要：Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s *** lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic *** work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral *** ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin *** vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone *** proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C *** healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in *** as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral *** rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.

摘要：介绍了一种基于反离子电渗方法的非侵入式血糖监测系统。该系统通过集成恒电流源和双恒电势仪电路,配合高灵敏度介体酶传感器,实现了反离子电渗抽取和抽取至体表葡萄糖的检测。并且通过良好的降噪和提升采样精度的设计,有效提高了测量的准确性。根据所检测的葡萄糖浓度与组织液葡萄糖浓度以及血糖浓度间相对稳定的对应关系,本系统可以自动计算出血糖浓度。经过动物实验验证:该无创血糖监测系统经过一次有创校准后能够实现血糖监测。对比常规的有创测量方法,在动物血糖自然变化状态下,该系统的监测结果能够很好地反映出血糖的平均浓度值;在人为干预动物血糖浓度的情况下,该系统的监测结果能够较好地反映出血糖的变化趋势。

摘要：结合反离子电渗抽取原理,设计了一款基于MSP430F1611芯片的低功耗血糖仪,配合自制的三电极葡萄糖传感器,实现对组织液葡萄糖的无创抽取和低浓度葡萄糖的检测。该仪表采用MSP430F1611作为主芯片,对其它功能模块进行了低功耗设计,在3.7V工作电压下最大工作电流降低至17.31mA。设计了模拟实验和动物实验验证了该仪表的反离子电渗抽取和对低浓度葡萄糖的检测能力。仪表在模拟皮肤电阻阻抗小于80kΩ时,可实现恒流抽取,当大于80kΩ时,可实现恒压抽取。动物实验结果表明,可进行反离子电渗和检测。在葡萄糖浓度5～200μmol/L范围内,仪表的响应电流与葡萄糖浓度呈现良好的线性关系,线性相关系数为0.9979,检测灵敏度达到15.619nA(μmol/L)-1。仪表为动物实验研究奠定基础。

摘要：1950年以后,张大千先后旅居阿根廷、巴西、美国等地达二十多年。自其旅居之初,便将自己收藏的艺术珍品以极低的价格转售给文物管理部门,又将早年临摹的敦煌壁画捐赠给四川博物院和台北故宫博物院。张大千晚年定居台北,又将自己收藏的国宝级艺术珍品捐赠给台北故宫博物院。在张大千的影响下,张大千的徒孙孙凯按照他父亲遗言,将其父收藏的张大千作品和遗物捐赠给成都市人民政府。这些都体现着张大千艺术报国的爱国情怀,并激励着后世的画家。