摘要：Fail-safe topology optimization is valuable for ensuring that optimized structures remain operable even under damaged *** selectively removing material stiffness in patches with a fixed shape,the complex phenomenon of local failure is modeled in fail-safe topology *** this work,we first conduct a comprehensive study to explore the impact of patch size,shape,and distribution on the robustness of fail-safe *** findings suggest that larger sizes and finer distribution of material patches can yield more robust fail-safe ***,a finer patch distribution can significantly increase computational costs,particularly for 3D *** keep computational efforts tractable,an efficient fail-safe topology optimization approach is established based on the framework of multi-resolution topology optimization(MTOP).Within the MTOP framework,the extended finite element method is introduced to establish a decoupling connection between the analysis mesh and the topology description *** examples demonstrate that the developed methodology is 2 times faster for 2D problems and over 25 times faster for 3D problems than traditional fail-safe topology optimization while maintaining similar levels of robustness.

摘要：On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual ***,state-of-the-art microfluidic chips for droplet sorting still suffer from low sorting speeds,sample loss,and labor-intensive preparation ***,we demonstrate the development of a novel microfluidic chip that integrates droplet generation,on-demand electrostatic droplet charging,and high-throughput *** charging electrode is a copper wire buried above the nozzle of the microchannel,and the deflecting electrode is the phosphate buffered saline in the microchannel,which greatly simplifies the structure and fabrication process of the ***,this chip is capable of high-frequency droplet generation and sorting,with a frequency of 11.757 kHz in the drop *** chip completes the selective charging process via electrostatic induction during droplet ***-demand charged microdroplets can arbitrarilymove to specific exit channels in a three-dimensional(3D)-deflected electric field,which can be controlled according to user requirements,and the flux of droplet deflection is thereby significantly ***,a lossless modification strategy is presented to improve the accuracy of droplet deflection or harvest rate from 97.49% to 99.38% by monitoring the frequency of droplet generation in real time and feeding it back to the charging *** chip has great potential for quantitative processing and analysis of single cells for elucidating cell-to-cell variations.

摘要：Short-range ordering(SRO)is one of the most important structural features of high entropy alloys(HEAs).However,the chemical and structural analyses of SROs are very difficult due to their small size,complexed compositions,and varied *** electron microscopy(TEM)as well as its aberration correction techniques are powerful for characterizing SROs in these compositionally complex *** this short communication,we summarized recent progresses regarding characterization of SROs using TEM in the field of *** using advanced TEM techniques,not only the existence of SROs was confirmed,but also the effect of SROs on the deformation mechanism was ***,the perspective related to application of TEM techniques in HEAs are also discussed.

摘要：Aqueous zinc-ion batteries(AZIBs)show great potential for applications in grid-scale energy storage,given their intrinsic safety,cost effectiveness,environmental friendliness,and impressive electrochemical ***,strong electrostatic interactions exist between zinc ions and host materials,and they hinder the development of advanced cathode materials for efficient,rapid,and stable Zn-ion *** and their derivatives possess a large interlayer spacing,excellent hydrophilicity,outstanding electronic conductivity,and high redox *** materials are considered“rising star”cathode candidates for *** comprehensive review discusses recent advances in MXenes as AZIB cathodes from the perspectives of crystal structure,Zn-storage mechanism,surface modification,interlayer engineering,and conductive network design to elucidate the correlations among their composition,structure,and electrochemical *** work also outlines the remaining challenges faced by MXenes for aqueous Zn-ion storage,such as the urgent need for improved toxic preparation methods,exploration of potential novel MXene cathodes,and suppression of layered MXene restacking upon cycling,and introduces the prospects of MXene-based cathode materials for high-performance AZIBs.

摘要：High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer *** entails connecting hundreds or thousands of electrode wires on a limited *** study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode *** challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology *** flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic *** minimum spacing between electrodes was 15μm,comparable to the diameter of a single *** hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter *** flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

摘要：当供电接触轨振动的位移量过大时,将对接触轨造成损伤,因此地铁工程师需不定期监测供电接触轨振动情况并记录。为方便地铁工程师监测供电接触轨振动情况,研制了地铁供电接触轨振动位移量检测装置。该装置以STM32F103R8T6型ARM芯片为核心,实时检测振动变送器输出的4 mA~20 mA模拟电信号,计算振动位移量数值,并驱动ARM内部RTC模块生成日期和时间信息,每隔10 ms将日期、时间和振动位移量数值记录1次,将该数据记录在TF卡的TXT文件中。该装置对供电接触轨振动位移量的监测效果理想且成本低廉,值得在轨道交通行业内推广应用。

摘要：有轨运输电机车是有色金属矿山井下矿石转运的主要设备,受井下巷道结构复杂、网络基础设施薄弱等因素影响,需要投入大量人力在现场配合电机车司机完成相关运输任务,实际作业过程中存在操作人员劳动强度大、易发生机械伤害等诸多问题。金川集团信息与自动化工程公司通过对放矿及道岔控制进行自动化改造,并将视频监控、漏泄通讯、红区管控等系统有机结合,实现井下有轨电机车的远程放矿及无人值守,在有色矿山具有推广应用和借鉴价值。

摘要：考察了国产他达拉非(1)口溶膜在中国健康男性志愿者体内的药物动力学特征及其相对于1片的生物利用度。空腹试验采用随机、开放、三周期、双重拉丁方交叉试验设计,36名健康志愿者按1∶1∶1随机接受1口溶膜(不饮水)、1口溶膜(饮水)或1片(饮水);餐后试验采用随机、开放、两周期、交叉试验设计,志愿者按1∶1随机接受1口溶膜(饮水)或1片(饮水)。采用LC-MS/MS法检测血浆中1的浓度,并应用Win Nonlin 8.1软件计算药动学参数,SAS 9.4软件进行统计分析。结果表明,与1片相比,空腹试验中1口溶膜的主要药动学参数(c_(max)、AUC_(0→t)和AUC_(0→∞))几何均数比值的90%置信区间均落在80%~125%;而餐后试验中,1口溶膜的c_(max)未落在80%~125%。由此可见,空腹条件下,1口溶膜在不饮水及饮水条件下与1片均具有生物等效性,而在餐后条件下不具有生物等效性。

摘要：针对负载扰动造成永磁同步电机(PMSM)调速控制系统性能下降的现象,提出了基于新型趋近律的无模型滑模控制算法。搭建PMSM转速环超局部模型,利用新型趋近律来提高系统趋近阶段的收敛速度,并设计了一个改进无模型滑模控制器增强抑制扰动。通过与传统的PI控制的实验结果进行对比,验证了所提方法动态响应强,具有强抗扰能力。

摘要：Bone screws are devices used to fix implants or bones to ***,conventional screws are mechanically fixed with thread and often face long-term failure due to poor *** improve osseointegration,screws are evolving from solid and smooth to porous and *** manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and *** paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw ***,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing *** the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore *** addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi *** the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated ***,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated *** osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.