摘要：Conducting polymers(CPs),including poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS),are promising coating materials for neural ***,the weak adhesion of CP coatings to substrates such as platinum-iridium is a significant challenge that limits their practical *** address this issue,we used femtosecond laser-prepared hierarchical structures on platinum-iridium(Pt-Ir)substrates to enhance the adhesion of PEDOT:PSS ***,we used cyclic voltammetry(CV)stress and accelerated aging tests to evaluate the stability of both drop cast and electrodeposited PEDOT:PSS coatings on Pt-Ir substrates,both with and without hierarchical *** results showed that after 2000 CV cycles or five weeks of aging at 60℃,the morphology and electrochemical properties of the coatings on the Pt-Ir substrates with hierarchical structures remained relatively *** contrast,we found that smooth Pt-Ir substrate surfaces caused delamination of the PEDOT:PSS coating and exhibited both decreased charge storage capacity and increased ***,enhancing the stability of PEDOT:PSS coatings used on common platinum-iridium neural electrodes offers great potential for improving their electrochemical performance and developing new functionalities.

摘要：The interfacial performance of implanted neural electrodes is crucial for stimulation safety and the recording quality of neuronal *** paper proposes a novel surface architecture and optimization strategy for the platinum–iridium(Pt–Ir)electrode to optimize electrochemical performance and wettability.A series of surface micro/nano structures were fabricated on Pt–Ir electrodes with different combinations of four adjustable laser-processing ***,the electrodes were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,cyclic voltammetry,electrochemical impedance spectroscopy,and wetting *** results show that electrode performance strongly depends on the surface *** scanning overlap along with moderate pulse energy and the right number of pulses leads to enriched surface micro/nano structures and improved electrode *** raises the maximum charge storage capacity to 128.2 mC/cm^(2) and the interface capacitance of electrodes to 3.0×10^(4)μF/cm^(2) for the geometric area,compared with 4.6 mC/cm^(2) and 443.1μF/cm2,respectively,for the smooth Pt–Ir *** corresponding optimal results for the optically measured area are 111.8 mC/cm^(2) and 2.6×10^(4)μF/cm^(2),which indicate the contribution of fner structures to the ablation *** hierarchical structures formed by the femtosecond laser dramatically enhanced the wettability of the electrode interface,giving it superwicking properties.A wicking speed of approximately 80 mm/s was *** optimization strategy,leading to superior performance of the superwicking Pt–Ir interface,is promising for use in new neural electrodes.

摘要：Objective] This study aimed to determine the effects of medium composi-tion and fermentation condition on the production of antibiotics from an actinomycete antagonistic to Penicil ium viridicatum, which was isolated from soil and identified primarily as Streptomyces anandi . [Method] Single-factor experiments and orthogonal array designs were used to optimize the medium composition and fermentation con-ditions. [Result] Culture medium composition and fermentation conditions showed sig-nificant influence on the antibiotic production from S. anandi . The optimum culture medium consisted of soluble starch 10 g/L, soybean cake powder 15 g/L, KH2PO4 0.5 g/L and MgSO4·7H2O 0.1 g/L. The optimized fermentation conditions were tem-perature 30 ℃, initial pH value 7.7, culture medium amount 40 ml/250 ml flask, and fermentation time 144 h. The titer of fermentation broth reached 452.7 U/ml when the S. anandi was cultured under the optimal fermentation medium and conditions. [Conclusion] The study may lay the foundation on further isolation and purification of the antibiotic from S. anandi JXNU02.

摘要：有源植入式医疗器械是中国医疗器械产业实现转型升级和高质量发展目标的关键领域。该文概述了高风险有源植入式医疗器械的可靠性特点。从系统级、部件级到元器件级3个层面,系统阐述了有源植入式医疗器械领域的可靠性研究进展。在系统级,主要关注有源植入式医疗器械寿命的影响因素、关键部件之间的连接和医生手术过程的再操作等。在部件级,电路板的可靠性保障与传统高可靠性保障方法相比发生了显著变化,简化元件级试验并增加用户板级试验内容,结合实际工况设计相关试验条件和判据,成为了商用器件用于高可靠领域的可靠性保障的发展方向。电极与组织之间相互作用的长期可靠性是有源植入式医疗器械可靠性研究的重点内容。在元器件级,以电容为例对关键部件用于有源植入式医疗器械领域的可靠性问题进行了结合应用场景的分析。此外,微小型植入式医疗器械因植入简单,能够降低和导线密切相关的电磁兼容、核磁等风险,同时能够避免因导线变形、断裂等引发的可靠性问题,成为有源植入式医疗器械的重要发展方向,其可靠性先行的特征尤为明显。以设计应用方作为研究主体,侧重结合实际应用情况进行可靠性保障,是有源植入式医疗器械等高可靠性领域可靠性研究当前阶段的突出特点和发展趋势。

摘要：为研究小型氧化二氮(N2O)-有机玻璃(PMMA)混合火箭发动机,搭建了试验平台,设计并制造了N2O-PM-MA混合发动机试验样机。通过试验验证了试验平台和发动机设计,获得了N2O-PMMA混合发动机燃料燃速和氧化剂质量速度的关系公式。利用试验数据分析了燃料药柱几何尺寸、氧化剂质量速度和发动机喷嘴喉径对燃烧效率及推进性能的影响,探讨了这种发动机的优化设计范围。研究结果为未来小型混合发动机的工程应用提供了试验平台和科学依据。

摘要：审美价值是美学原理研究的基本问题,目前的审美价值研究通常在价值论的基础上进行。盖格尔将审美价值等同为艺术价值,并将其视为高级的、精神性价值,这固然凸显了人的独特意义,但也忽视了生态系统本身的价值,人类中心主义色彩较为浓厚。罗尔斯顿的环境价值理论表明,生态系统整体具有内在价值,一切价值均源于生态系统,因此自然的生态价值高于其审美价值。环境美学虽然注意到生态价值,但它仍赋予审美价值以优先地位,并未改变价值论美学的价值序列。戈比斯特借鉴罗尔斯顿的学说指出,当景观管理实践以审美价值统摄生态价值时,两者会发生尖锐冲突,其生态美学概念模型将两种价值统一于审美体验中。简言之,生态美学充分借鉴并吸收了当代伦理学的内在价值学说,将生态价值置于突出位置,以生态价值为基准反观审美价值的特性及其在价值序列中的恰当位置,规范生态价值与审美价值的应然关系,从而推进了美学原理研究。

摘要：当前,老炼仍被广泛应用于塑封微电路(PEM)的可靠性保证。为了解决老炼过程中存在的热失控及温度不一致的问题,该文设计了一套温度闭环控制系统。在由老炼箱自身装置提供箱内基础温度的基础上,设计的温度闭环控制系统以每个封装夹具内的微环境为控制对象,采用模糊自适应算法,最优配置比例积分(PI)控制器的控制参数,最终驱动执行器,对被老炼器件及时加热或散热。通过试验证实,老炼过程中加入温度闭环控制系统后,被测器件的温度在更短的时间内(20min)达到稳态,稳态精度控制在1℃以内,且被测器件温度的差异由2℃降低到基本一致。而后,当系统采用模糊自适应控制算法后,系统的动态响应时间更短,抗干扰能力更强。因此,该系统达到了防止器件热失控及保证不同器件间温度一致的目的。

摘要：以衣康酸(IA)、丙烯酸(AA)和甲基丙烯酸羟乙酯(HEMA)为单体,采用水溶液聚合法制备三元共聚阻垢剂IA-AA-HEMA,以阻垢率为指标,利用称垢法评价其阻垢效果;利用P-B试验和CCD实验优化阻垢剂制备条件。结果表明IPA投加量15%、KPS投加量8%、单体配比nIA∶nAA∶nHEMA=1∶0.5∶0.3、聚合温度86℃、聚合时间85 min的最优条件下,阻垢率最大可达96.69%,其中聚合温度和单体配比nIA∶nAA对阻垢率的影响极为显著,聚合时间和KPS显著影响次之。红外光谱表征表明IA-AA-HEMA阻垢剂聚合成功,CaCO3垢样的扫描电镜分析结果表明加入IA-AA-HEMA后CaCO3垢样结构明显疏松,阻垢效果良好。

摘要：【目的】浙江某配水工程四期接入三期系统,四期支线流量需求变幅大,以减小四期工程的建设对三期工程影响为目的。【方法】针对四期工程的布置特点,首先开展"池后加压"方案及"管内加压"2个方案水力学设计;接着采用对比的方法,系统开展2个方案的水力学比较;最后,对优选的方案进行了水锤防护分析。【结果】"池后加压"方案更优,泵后阀及管道出口阀采用分段关闭和管线上下游布置调压室联合进行的水锤防护。【结论】该研究思路及研究成果可为类似工程的设计提供参考。

摘要：有源植入式医疗设备的金属外壳在磁耦合能量传输应用中,由于涡流效应而限制了磁耦合能量传输的效率,且带来装置发热问题。针对该问题,该文建立含金属介质的磁耦合能量传输的等效电路模型,提出以接收效率为优化目标的系统设计方法,并用于可充电脑起搏器的研制。根据等效电路模型,接收效率取决于接收线圈匝数、负载阻抗和阻抗匹配参数;较高的等效负载阻抗会带来接收线圈最佳匝数增加,同时导致传输功率、传输效率和接收效率增加;电容串联补偿时,最佳补偿电容在较大值时获得,电容并联补偿时,最佳补偿电容在较小值时获得。动物试验结果表明,所研制的可充电脑起搏器在无温度控制下,最高温度多数分布在36~38℃,满足临床使用要求。