摘要：Some effective parameters on the copper extraction from Küre chalcopyrite concentrate were optimized by using response surface methodology(RSm).Experiments designed by RSm were carried out in the presence of ammonium persulfate(APS) and different types of impeller in an autoclave *** persulfate concentration and leaching temperature were defined numerically and three types of impellers were defined categorically as independent variables using experimental design *** optimum condition for copper extraction from the chalcopyrite concentrate is found to be ammonium persulfate concentration of 277.77 kg/m3,leaching temperature of 389.98 K and wheel type of *** proposed model equation using RSm has shown good agreement with the experimental data,with correlation coefficients R2 and R2adj for the model as 0.89 and 0.84,respectively.