摘要：The application of the response surface methodology and the central composite design（CCD） technique for modeling and optimization of the influence of some operating variables on copper,molybdenum and rhenium recoveries in a bioleaching process was *** main bioleaching parameters,namely pH,solid concentration and inoculum percent,were changed during the bioleaching tests based on *** ranges of the bioleaching process variables used in the design were as follows：pH1.46-2.14,solid concentration 0.95%-11.05%,and inoculum percent 1.59%-18.41%.A total of 20 bioleaching tests were carried out by the CCD method according to software-based designed *** model equations were developed according to the copper,molybdenum and rhenium recoveries obtained with these three *** equations of responses at the base of parameters were achieved by using statistical *** model equations were then individually optimized by using quadratic programm.ng to maximize copper,molybdenum and rhenium recoveries individually within the experim.ntal *** optimum conditions for copper recovery were pH 1.68,solid concentration 0.95% and the inoculum 18.41%（v/v）,while molybdenum and rhenium recoveries were 2.18% and 24.41%,*** predicted values for copper,molybdenum and rhenium recoveries were found to be in good agreem.nt with the experim.ntal *** jarosite formation during bioleaching tests was also investigated.