摘要：A series of novel 3-（（4-（t-buty-）-2-（2-benzylidenehydrazinyl）thiazol-5-yl）methyl）quinolin-2（1H）-ones （7a--7z） were designed, synthesized and evaluated for their ability of inhibiting neuraminidase （NA） of influenza H1N1 virus. Some compounds displayed moderate influenza NA inhibitory activity. Compound 71 with the scaffold of 2-（2-（2-methoxybenzylidene）hydrazinyl）thiazole was the best one, exhibiting moderate NA inhibitory activity with ICs0 of 44.66 ~tmol/L. Structure-activity relationship showed that compounds with methoxy or hydroxy groups at the ortho position, fluorine and nitro groups at the meta position and chlorine and bromine groups at the para posi- tion of phenyl ring were more active. Docking study indicated that compound 71 has important interactions with some key residues （including Asp151, Glu119, Arg292, Tyr406, and Asn347） and binds to 430-cavity adjacent to NA active site.

摘要：中医药院校制药工程专业的工科属性决定了工科课程是其培养计划中的重要组成部分。但由于知识体系的限制,学生普遍在学习工科知识的过程中感受到知识点较为抽象,难以理解,而中医药知识背景及中医药文化氛围也为之提供了相关课程教学过程中的参照及基础,将工科知识的传授融合中医药知识点,充分利用学生的先验知识背景,有效降低学生学习时的难度,以学生易于接受的知识传授模式讲授抽象的知识点,明显提高学生的接受程度,解决相关知识点教学的痛点难点,取得较好的教学效果,是教学设计时可以重点考虑的内容。

摘要：立德树人是当前我国教育的根本任务。为培养适合当今社会发展的新时代人才,充分发挥中国特色社会主义教育的育人优势,高校应着力构建"三全育人"立体化培养体系,将思政教育与专业知识教育、专业实践教育有机融合起来,构建课程思政教学体系,实现高校思政教育工作全覆盖,有力推动高等教育"三全育人"教学体系的构建,为完成立德树人这一根本任务奠定基础。