摘要：Reliability of medical devices such as infusion pumps is extremely important because these devices are being used in patients who are in critical condition. Occlusion pressure, as an important parameter of infusion pumps, should be detected when an occlusion occurred. How-ever, infusion pumps’ occlusion pressure could not be tested and the performance of these pumps is not known to us. In order to test the occlusion pressure of infusion pump, a testing system has been put forward according to standards of IEC 60601-2-24:1998/ GB 9706.27- 2005. The system is comprised of sensor, acquisition card, three-way tap and so on;this system is controlled by a PC. At the same time, sampling rate could be changed if necessary and test time could be recorded. And then the characteristics of this system were studied, such as linear, effects of pump rates and different pumps. The system remained linear in a given environment. The higher is the pump rate, the faster is the time to reach occlusion condi-tion. The testing system has been proved to be effective in testing the occlusion pressure of infusion pumps and the accuracy error of pressure is content the demand of ±1% of range.

摘要：A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.

摘要：基于有色金属材料在工业CT环境下同时进行拉伸和断层扫描的特殊试验要求,首次采用非金属材料聚碳酸酯作为试验机机架,设计了一种微型材料拉伸试验机。采用伺服电机作为加载动力源,为解决伺服电机及传动机构的非线性影响加载精度问题,设计了模糊PID控制算法,以满足加载实时控制的精度要求。仿真和实验证明了新型微型试验机方案的有效性。

摘要：鸟类鸣声复杂,在鸟类的生活史中具有重要意义。自19世纪50年代末期基于声音回放技术开展鸟类鸣声、行为及生理等研究以来,鸟类学家取得了许多单靠鸣声声谱分析所无法取得的成果。但在中国,回放技术在鸟类学的应用尚处于起步阶段。根据现有的研究资料总结了相对于其他动物而言,回放技术在鸟类学研究中应用更为广泛的原因;对回放技术在种间关系、种内识别、种群数量调查、行为及生理等领域的应用及其意义进行了综述;对回放实验中存在的不稳定因素、假重复问题以及回放反应评估体系进行了讨论;并对回放技术在鸟类分类学及濒危鸟类监测中新的应用以及互动回放技术的发展前景进行了展望。

摘要：利用复合酶法综合提取海带中的褐藻糖胶和海藻酸,以提高海带资源利用率。通过单因素和正交试验对复合酶解条件进行优化,结果表明,复合酶的最佳配比为:纤维素酶∶木聚糖酶∶果胶酶∶蛋白酶∶淀粉酶=60∶20∶10∶15∶1.6,复合酶的作用条件为:料液比1∶30、加酶量6.05%(以海带干重计)、p H4.8、酶解温度55℃、酶解时间18h。采用优化的提取方法获得的褐藻糖胶得率为2.30%,硫酸基含量22.9%,一次提取率92.1%,海藻酸得率26.12%,一次提取率87.1%,显著高于其他的相关研究报道。由以上结果可知,复合酶酶解提取是一种提高海带利用率的有效方法,并为海带资源的高值化利用提供了新的思路。

摘要：为构建区域干旱的高精度简化估算模型,以中国北方农牧交错带为研究区域,选择该区域12个气象站点,计算不同站点3个月、6个月、12个月的标准化降雨蒸散指数(SPEI-3、SPEI-6、SPEI-12),以表征区域干旱,使用时间卷积神经网络模型(TCN)来提取序列数据的特征,同时输入到双向长短期记忆神经网络模型(BiLSTM)中进行进一步的处理,构建组合模型(BT),采用麻雀搜索算法(SSA)和Attention机制对组合模型进行优化,构建SSA-BiLSTM-TCN-Attention模型(SBTA),同时计算了SBTA模型精度,基于均方误差(MSE)、决定系数(R^(2))和效率系数(E_(NS))以及GPI指数的模型精度评价体系进行精度验证,结果表明:SBTA模型MSE值仅为0.041~0.200,R^(2)和E_(NS)在全区取值均在0.9以上,在全区的误差最低、一致性最高,在所有模型中精度排名第1,可推荐SBTA模型用于北方农牧交错带干旱估算当中。

摘要：目的探讨虫草素(cordycepin,COR)减轻庆大霉素(gentamicin,GEN)肾毒性的作用及其抑制GEN诱导的氧化应激和细胞铁死亡的分子机制。方法将SD大鼠分为对照组、GEN组与GEN+COR组3组,动物模型构建成功后,检测各组大鼠血清肌酐和尿素氮水平,HE染色评价肾脏组织损伤程度。另外,检测各组SD大鼠肾脏组织中丙二醛和谷胱甘肽含量,并通过Western blot的方法分析细胞铁死亡标志蛋白GPX4、SLC7A11表达。结果与对照组相比,GEN组大鼠血清肌酐、尿素氮明显升高(P<0.01),同时给予50 mg·kg-1 COR后有效降低肌酐与尿素氮水平,HE结果也显示COR能够缓解GEN造成的肾脏组织损伤;COR可逆转GEN造成的大鼠肾脏组织中丙二醛水平升高与谷胱甘肽水平下降。同时,COR能够恢复GEN诱导的GPX4、SLC7A11蛋白水平下降。结论COR能够通过减轻细胞氧化应激与铁死亡缓解GEN造成的肾损伤。

摘要：针对兴趣点推荐中无法精准捕捉POI之间地理影响和高效学习用户-兴趣点(POI)交互行为动态表示的问题，提出一种融合地理和时空信息的对比兴趣点推荐方法(IGST-CL)。采用地理插值采样策略来缓解数据不平衡问题，利用一种动态消息传播机制的图卷积网络精准捕获地理影响。采用一种基于正余弦时间函数的时间注意力机制和超图网络联合学习用户-POI交互行为的动态表示。采用对比学习策略进一步增强模型性能。基于多任务学习方法自适应融合上述3个任务推断用户偏好。基于多个基准数据集的实验分析验证了IGST-CL模型相比其它主流兴趣点算法的优越性。

摘要：Efficient photogenerated carrier migration/separation plays a critical role in increasing the photocatalytic performance of g-C_(3)N_(4).Herein,sulfonic acid group-functionalized g-C_(3)N_(4)(SACN)was synthesized and then synchronously strengthened by a facile-solid-state thermal reaction of g-C_(3)N_(4)and sulfamic *** a solid strong acid,sulfamic acid can be used to achieve acid etching on the surface of g-C_(3)N_(4)with the assistance of thermal treatment,leading to an enlarged specific surface area and increased surface catalytic reaction *** importantly,our experiments and density functional theory calculations indicate that the driving force generated by the negative inductive effect of sulfonic acid groups significantly improves the charge transfer dynamics and effectively inhibits their ***,the negative inductive effect can induce charge redistribution,which reduces the conduction band potential of g-C_(3)N_(4)to enhance the reduction ability of photo-induced *** a result,the SACN-400 sample showed excellent photocatalytic performance in H2 generation with an apparent quantum efficiency of 11.03%at 420±15 nm,as well as an efficient photodegradation rate for organic pollutants.

摘要：文章以民间文化视角切入,考察1979年至2019年间五部哪吒题材动漫作品中哪吒之母形象跟随时代变化的建构轨迹。从《哪吒闹海》到《封神榜传奇》,母亲形象的由虚到实隐含着民众对安定与达观的精神追求;《哪吒传奇》与《我是哪吒》以女娲和莲花类比母亲,传达出民众推崇母性与实用之美的观念;《哪吒之魔童降世》中的母亲形象走下神坛,其显示的民间文化元素照应着现实,透射出人情人性美与真实感。文章认为母亲形象的变化展现了民间文化与流行文化的融合,这为国漫的创作带来了新思考。