摘要：Several novel C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond were rationally designed and easily synthesized at room temperature by using the unprotected sugar aldehyde as the starting material. The effects of the compounds on Con A-induced T cell proliferation were evaluated at five concentrations of 5, 10, 25, 50, and 100 mmol/L Interestingly,compounds 7a and 8a（n = 2, R = H） exhibited immunostimulating activities, while compounds 5a, 6a（n = 1, R = H） and 7b, 8b（n = 2, R = CH3） showed immunosuppressive activities. Another two compounds 5 b and 6b（n = 1, R = CH3） had no immunomodulating activities. These initial biological results suggested that subtle structural changes to the phenyl and acetamide bond of C-pseudonucleosides could have a significant effect on T cell proliferation bias, although it was difficult to formulate a rigorous structureactivity relationship based on the observed activities.

摘要：设计开发高效的催化体系用于可控制备高分子量聚酯材料,一直以来都是可降解高分子材料研发的重点.本文报道了一种配体框架中含有Salen键和Catam键的新型不对称铝配合物.这种特殊的配体结构可以促进中心金属对环酯单体(如ε-己内酯(ε-CL)和δ-戊内酯(δ-VL))的活化作用,赋予铝配合物高活性催化环酯单体开环聚合的能力,实现了高分子量聚酯材料的可控合成.首先,考察比较了铝配合物结构和反应条件(温度、单体比例和单体结构)对催化聚合反应的影响规律.在优化反应条件后,轴配位为苄氧基的铝配合物,可以在10 min内快速催化ε-CL、δ-VL及其混合单体的聚合反应,合成得到数均分子量高达175.7~443.8 kg·mol-1的聚酯材料.进一步计算比较了混合单体比例和反应温度等条件对无规共聚酯材料平均链段长度的影响,并详细表征了聚酯材料的组分结构与材料热学性能的关系.

摘要：目的了解十堰地区中小学生心理健康现状。方法采用国内修订版4套评估工具Achenbach儿童行为量表中国标准化版增订版、学习障碍筛查量表、Conners儿童行为问卷父母量表、教师量表及自行设计的一般情况调查表,采取随机抽样方式对十堰市茅箭区区属18所学校11611名中小学生、教师及家长发放问卷,进行调查测评分析。结果89.29%的中小学生具有远大理想和崇高追求,具有正确的人生观和价值观,10.71%的中小学生存在着较为严重的心理问题,主要表现为学习目的不明确,缺乏学习积极性及自觉性,自信心缺乏,自责倾向严重,心理承受能力差,冲动倾向严重,焦虑与情绪不稳定、孤独倾向造成冷漠、羞怯、与人交往困难。结论学校、家庭、社会全方位关注学生心理健康,才会促进中小学生心理向健康方向发展。

摘要：In view of the problem that it＇s difficult to accurately grasp the influence range and transmission path of the vehicle top design requirements on the underlying design parameters. Applying directed-weighted complex network to product parameter model is an important method that can clarify the relationships between product parameters and establish the top-down design of a product. The relationships of the product parameters of each node are calculated via a simple path searching algorithm, and the main design parameters are extracted by analysis and comparison. A uniform definition of the index formula for out-in degree can be provided based on the analysis of out- in-degree width and depth and control strength of train carriage body parameters. Vehicle gauge, axle load, crosswind and other parameters with higher values of the out-degree index are the most important boundary condi- tions; the most considerable performance indices are the parameters that have higher values of the out-in-degree index including torsional stiffness, maximum testing speed, service life of the vehicle, and so on; the main design parameters contain train carriage body weight, train weight per extended metre, train height and other parameters with higher values of the in-degree index. The network not only provides theoretical guidance for exploring the relationship of design parameters, but also further enriches the appli- cation of forward design method to high-speed trains.

摘要：Lumbar degeneration leads to changes in geometry and density distribution of vertebrae,which could further influence the mechanical property and *** study aimed to quantitatively describe the variations in shape and density distribution for degenerated vertebrae by statistical models,and utilized the specific statistical shape model(SSM)/statistical appearance model(SAM)modes to assess compressive strength and fracture *** detailed SSM and SAM were developed based on the 75 L1 vertebrae of elderly men,and their variations in shape and density distribution were quantified with principal component(PC)*** vertebrae were classified into mild(n=22),moderate(n=29),and severe(n=24)groups according to the overall degree of *** computed tomography-based finite element analysis was used to calculate compressive strength for each L1 vertebra,and the associations between compressive strength and PC modes were evaluated by multivariable linear regression(MLR).Moreover,the distributions of equivalent plastic strain(PEEQ)for the vertebrae assigned with the first modes of SSM and SAM at mean±3SD were *** Leave-One-Out analysis showed that our SSM and SAM had good performance,with mean absolute errors of 0.335±0.084 mm and 64.610±26.620 mg/cm3,respectively.A reasonable accuracy of bone strength prediction was achieved by using four PC modes(SSM 1,SAM 1,SAM 4,and SAM 5)to construct the MLR ***,the PEEQ values were more sensitive to degeneration-related variations of density distribution than those of *** density variations may change the deformity type(compression deformity or wedge deformity),which further affects the fracture *** models can identify the morphology and density variations in degenerative vertebrae,and the SSM/SAM modes could be used to assess compressive strength and fracture *** above findings have implications for assisting clinicians in pathological dia

摘要：从NCBI公共数据库下载2 535条杜鹃花相关表达序列标签（expressed sequence tags,EST）,SSR位点搜索共得到435个位点。利用Primer5.0对重复基元数较大的30个SSR位点设计引物,通过混合基因池进行引物初筛,25对引物可扩增出条带;利用非变性聚丙烯酰胺凝胶（PAGE）研究25对SSR引物的PCR扩增特点。14个SSR位点为多态性,各位点的等位基因介于2-5个,平均等位基因数3.8个;观望杂合度Ho、期望杂合度He、多态信息含量PIC范围分别为0-0.8333、0.0816-0.7172、0.0767-0.6471;多态位点中有5个高度多态、7个中度多态和2个低度多态。非加权配对算术平均法（UPGMA）聚类分析结果表明：开发的14个EST-SSR标记能有效鉴定种质资源,对于杜鹃花品种的鉴定与遗传多样性分析具有重要应用价值。

摘要：针对分布式光伏大量无序接入配电网导致的安全风险问题,设计有源配电网分布式光伏承载力分析平台,旨在帮助电网调度部门全面掌握区域电网承载能力,实现分布式光伏承载力的可观可测。首先,分析了分布式光伏承载力的评估指标,按照分层分区原则,从局部到整体、低压到高压,按供电区域和电压等级开展电网承载能力评估;然后,进行热稳定计算、电压偏差、短路电流等校核,确定供电区域内的承载等级和可新增电源容量;最后,实现有源配电网分布式光伏承载力平台,提供可接入容量计算、承载力评估、统计分析等功能及可视化结果。经验证,所设计的分布式光伏承载力分析方案能够评估区域配电网各级母线的承载力及可接入容量,并将分析结果进行可视化展示。

摘要：以传统陶瓷工艺技术的研究成果,结合长期的陶瓷艺术设计、实际制作和现行的技艺规则及生活习尚,对银沟遗址出土陶瓷标本中部分特征较强的碗类器物在时代判断、制作工艺、造型装饰、规格使用等方面的成因加以分析研究。从而得出了这部分陶瓷的烧制技术特点、装饰艺术及美学风格及它在整个中国陶瓷史上的作用和地位。

摘要：作为连接不同电压等级直流母线的关键设备之一,DC-DC变换器转换效率的提高对于建立直流电网有重要意义。为了降低大功率软开关DC-DC变换器的体积和质量,基于旋转电容构造了一种能够实现功率器件零电流关断的非隔离型双向DC/DC变换器。介绍了变换器的电路拓扑结构;分析了不同模式下的稳态工作过程;设计了器件的具体参数及控制方案并研究了变换器的损耗特性;最后,在Matlab/Simulink中搭载仿真模型,验证了设计方案和控制策略的正确性。结果表明,所设计的变换器能够实现开关管和二极管的零电流关断,具有较高的转换效率。

摘要：基于性能化评估数据,采用亚安全区概念,改进了重庆某大型商业中心防火设计方案。通过合理划分防火分区,依据国内商业实际运行数据设定火灾场景,模拟人群疏散效果,通过窗型喷头加钢化玻璃的隔离方案和独立防火单元强化防火设计。性能化评估结果及相关实验结果表明亚安全区及独立防火单元的相关设计为大型商业综合体的防火设计提供了借鉴方案。