摘要：Several novel C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond were rationally designed and easily synthesized at room temperature by using the unprotected sugar aldehyde as the starting material. The effects of the compounds on Con A-induced T cell proliferation were evaluated at five concentrations of 5, 10, 25, 50, and 100 mmol/L Interestingly,compounds 7a and 8a（n = 2, R = H） exhibited immunostimulating activities, while compounds 5a, 6a（n = 1, R = H） and 7b, 8b（n = 2, R = CH3） showed immunosuppressive activities. Another two compounds 5 b and 6b（n = 1, R = CH3） had no immunomodulating activities. These initial biological results suggested that subtle structural changes to the phenyl and acetamide bond of C-pseudonucleosides could have a significant effect on T cell proliferation bias, although it was difficult to formulate a rigorous structureactivity relationship based on the observed activities.

摘要：本文探讨的是中国语境下的城市保护。作者以三个中国历史文化街区为例,对历史街区的居民、政府及文物保护专业人士在原真性、集体记忆及其空间表现形式等方面的理解差异作了分析。本文提出采取一种具有文化敏感性的方式,将公众历史(视角/视野/解读/敏感性/结论)融入(政府部门的)城市保护工作。

摘要：K-ion batteries(KIBs)hold great promise for large-scale energy ***,the absence of suitable cathode materials limits their practical ***,rationally designing advanced cathode materials for KIBs remains an open *** this work,based on density functional theory calculations,we find that the bond stability of Fe–O is higher than that of Co–O in layered transitional metal(TM)***,the K-ion migration in the Fe-based layered TM oxide has a significantly lower activation energy barrier than that in the Co-based *** on this theoretical prediction,we successfully synthesized a low-cost K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode,which shows excellent structural stability and superior K-storage properties,including durable cycle life and high-rate ***,the designed K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode possesses a great full-cell performance with a discharge capacity of~75 mA h g^(-1) and capacity retention of~80%after 100 *** results show that Fe has better structural stability and K-ion diffusion than high-cost Co in layered oxide cathodes,and this finding provides new insights into the design of low-cost and high-performance KIB layered *** work highlights the feasibility of a theory-guided experiment in screening promising battery materials.

摘要：本文通过对卸料斜面的位置,初始卸料角及终止卸料角的理论分析,找出了离心式卸料斗式提升机的回料原因,求得最佳参数和料斗形状。根据抛料流轮廓设计头罩等。对斗式提升机设计和使用具有指导意义。

摘要：针对现有计算方法的不足,本文以柔索力学的理论出发,提出了一个新的不加护轨的大倾角裙式(槽形)输送机最小曲率半径计算公式;分析了加护轨时护轨的受力情况并讨论了如何根据情况决定是否加护轨。

摘要：钢丝绳作为一种普通的机械零件产品,在工农业生产中有着广泛的应用,如提升及紧固的场合等。本文分析了钢丝绳在氧化铝厂‘钢索扭矩沉降槽’设备中的应用,通过对钢丝绳结构伸长(永久变形)和弹性变形的分析和研究得出了钢丝绳在承受一般恒力下所表现出的固有特征和规律,同时也提出对钢丝绳所承受各种各样变载下的结构伸长和弹性伸长,还应作进一步的研究和探索。

摘要：高压作为一种重要的热力学变量,可用于引发软物质系统中的各种结构变化。小角X射线散射具有高空间分辨能力,可用于蛋白质折叠动力学、核酸结构稳定机制研究,在生命科学领域具有广阔的应用前景。然而,目前国内尚缺少用于高压溶液散射的专用装置,为此,在上海光源BL19U2线站设计开发了一种专用于溶液X射线散射的高压原位样品装置和手动加压系统,实现了在0.1~250 MPa范围内静水压测量。该装置可实现X射线窗口在整个测量过程中保留在原位,有助于准确扣除背景散射,实现高信噪比测量,为食品科学、药理学、结构生物学等研究领域提供重要的研究平台。

摘要：表面增强拉曼光谱(SERS)因其独有的快速检测、高灵敏度、低检测限和无损分析等优点,在医学检验领域有着广泛的研究。SERS增强基底的成功构建是SERS技术实现以上优点的前提。本文介绍了SERS的增强机制,在血液检测中,对其增强基底的设计进行了分类及讨论,将其分为无标签基底和有标签基底两大类,并根据材料应用的不同和基底设计的方式不同进行进一步的细分。对近年来血液检测中SERS检测应用相关文献进行了回顾,综述了在血液检验中不同类型增强基底的设计方法及应用特征。最后,对SERS增强基底在血液检验中的设计进行了总结与展望。

摘要：数字技术颠覆并重塑了视障群体的媒介实践与社会生活,但也因此被统摄在视觉中心主义的技术环境与社会环境中。本研究基于田野调查与网络民族志考察,探究视障者数字阅读界面生成社会关系网络的过程,并揭示其间秩序协商的复杂形构。研究发现,围绕视障者数字阅读界面,立法与行政机关、公益事业单位、无障碍科研机构、互联网大厂等多元行动者入场,形成相互渗透交织的残健关系网络。该关系网络含有动态秩序联结与隐性秩序区隔的双重特征,既为视障者提供了群体认同和社会融入机会;同时又以工作界限和权力错位的形式,制造了视觉中心主义和结构性忽略导致的技术区隔效应。以上发现,为未来秉持“参与式设计”理念,持力优化视障者数字阅读基础设施,提供了新的理论视角与实践理路。

摘要：反复是歌词创作中高频率运用的一种修辞手段,歌词结尾反复的艺术程式有:无阶式和有阶式及其升、降格式,分析了反复对歌词结尾程式的艺术处理的修辞作用。