摘要：Objective: Given the grea. va.ia.ility of huma. chorionic gona.otropin (HCG) levels a.ter a.single dose of methotrexa.e (MTX) for ectopic pregna.cy, it rema.ns complica.ed to identify ca.es undergoing persistence until a.week from trea.ment. We eva.ua.ed whether pretrea.ment pa.terns of HCG levels could be useful for a. ea.lier detection of persistent trophobla.t. Study design: a.retrospective study on 62 pa.ients trea.ed by a.systemic single dose of methotrexa.e (50 mg/m2) for a. ectopic pregna.cy. Sa.ples for HCG detection were obta.ned on da.s -2 a.d 0 before the thera.y, on da.s +3, +7 a.d then weekly until va.ues were undetecta.le. Pa.ients were divided into three groups: Group U (up, mea.ing "increa.ing") a.d Group D (down, mea.ing "decrea.ing") when HCG levels on da. 0 were respectively higher or lower tha. da. -2 level of more tha. 20%a.d Group P (pla.ea.) when the difference between da.-2 HCG level a.d the level on da. 0 wa. less tha. 20%. Results: a.l the pa.ients of Group D underwent a.complete resolution, with a.percenta.e of 33.3%of ca.es who underwent a. initia. rise of HCG levels on da. +3. The percenta.e of ca.es undergoing a. initia. rise of HCG levels in Group U pa.ients wa. significa.tly higher tha. in Group P pa.ients (60.0%versus 28.6%), but the resolution ra.e resulted simila. in the two groups. For pa.ients of Group P, a. increa.e of HCG levels on da. +3 wa. significa.tly correla.ed to the fa.lure of the thera.y. Indeed, compa.ing the ca.es with a. immedia.e increa.e of HCG levels to the ca.es with immedia.e decrea.e of HCG levels on da. +3, the persistence ra.e wa. 80%for the former a.d 12%for the la.ter (P< 0.0001). Conclusion: a. initia. rise of HCG levels a.ter the thera.y does not seem to ha.e a.clinica. releva.ce in Group D a.d Group U pa.ients, it well correla.es to trophobla.tic persistence in Group P pa.ients.