摘要：Objective:To determine the efficacy and safety of oral erythromycin(EM) for feeding intolerance in p.eterm infants < 35 weeks gestation. Study design:In this randomized,double blinded,p.acebo-controlled trial,p.eterm infants with feeding intolerance were randomly allocated to a treatment group.given EM ethyl succinate 10 mg/kg every 6 hours for 2 days,followed by 4 mg/kg every 6 hours for another 5 days,or to a control group.given p.acebo. The p.imary outcome was time to full feeding (150 mL/kg/day) after the start of ***:Each group.comp.ised 23 p.eterm infants,almost all of whom were < 32 weeks gestation. Baseline characteristics were similar between the 2 group.. Times to full feeding were significantly shorter and the number of with held feeds were significantly less in the EM group.than the control group. the resp.ctive medians (interquartile ranges) were 7 days (6 to 9 days) versus 13 days (9 to 15 days) (p.< 0.001) and 1 ep.sode (0 to 2 ep.sodes) versus 9 ep.sodes (2 to 13 ep.sodes) (p.< 0.001).No significant differences in ep.sodes of sep.is,necrotizing enterocolitis,and cholestasis were observed. Conclusions:Oral EM was effective and safe for treatment of feeding intolerance in p.eterm infants.