摘要：总部位于巴塞罗那的年轻建筑事务所h3o建筑事务所推出了Relámpago住宅,这是他们最为特别和不同寻常的住宅项目之一。在巴塞罗那郊区圣胡斯特德斯韦恩的传统加泰罗尼亚农舍内,对一座面积55m2的谦逊老谷仓进行翻新,打造出一个色彩丰富的独特空间,向访客诉说着自己难忘的故事。项目的灵感源自业主的愿望,这是一位热爱创意和艺术的历史学家。设计师以多年前一道闪电穿越古老农舍的传说为出发点,力图在功能性和大胆设计中展现这一灵感,以激发客户的艺术兴趣。

摘要：Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanofiller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

摘要：设计命题极速城市化使城市变成一个高度雷同、自我复制的标准编码系统,学校也不例外.在快速增长的人口和教育需求的压力下,校园建设同样仰赖快速建造复制生产的模式.学校建筑被简化为"满足规范"的标准设计范式加常规的建造生产.建筑、尤其是校园营造所应具备的人本精神和社会文化职能缺失.

摘要：Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

摘要：2023年9月,“中国音乐文化与俄罗斯”国际学术研讨会在俄罗斯莫斯科国立柴科夫斯基音乐学院举行,两国数十位音乐学者参加。会议以中俄两国在音乐文化和音乐教育领域的交流互动、中国文化在俄罗斯音乐和苏联音乐中的印记、两国在音乐领域的研究现状和前景等议题为主。在研讨会框架内,举办了俄籍华裔作曲家左贞观新书《中国音乐文化概论》发布会、中国传统与当代作品音乐会等一系列学术、艺术活动。

摘要：意识形态安全与网络对话平台紧密相关,意识形态安全是网络对话平台建设的应然指向,网络对话平台是意识形态安全维护的重要载体。意识形态安全视阈下深入推进新时代网络对话平台建设,有助于加快促进网络对话双方良性互动,积极防范意识形态领域重大风险。进入新时代,我国网络对话平台建设环境发生了深刻变化,面临着诸如开放性与包容性存在隐患、虚拟性与现实性呈现割裂、便捷性与娱乐性日趋复杂等现实问题。对此,要在思想保障上,牢固树立网络意识形态安全思维;在话语设计上,生动展现网络意识形态话语特色;在媒体支持上,集中整合网络意识形态传播渠道;在制度完善上,建立健全多元主体协同治理机制。

摘要：近来备受关注的诺基亚全球策略／创意比稿中，成败决定性因素聚焦于一个细节，它可以预见谁将成为Nokia未来的广告代理商。

摘要：Groupe Galia办公楼位于巴黎11区的Villadu Clos-de-Malevart,原建筑改造前是一家汽车销售店。该大楼面朝内街且独立于周围的建筑,因此在这个建筑密集的区域内几乎是一个完全不透明的体量。经过设计团队简单却精心的策划干预,使得这座翻新建筑与城市环境重新建立起了联系。

摘要：地景缝合项目场地位于广州市白云区白云山东侧安静的甘园路里,现状为两幢建于不同年代的多层仓库。A幢为建于1980年代的4层印刷品仓库,总建筑面积9980m^(2),总高约17m;B幢为刚新建的5层仓库,总建筑面积12,000m^(2),总高约18m。设计任务是将这两幢空置厂房更新为以出租公寓和孵化办公基地为主的综合生活工作园区。

摘要：h3o建筑事务所是巴塞罗那一家年轻的设计公司,而同样位于巴塞罗那的Ti&beri俱乐部则以客制化的餐饮服务为人们所熟知。为了重新定义本地传统酒吧的体验,Tiberi俱乐部联手h3o建筑事务所的3位创始人Adri,orriols、JoanGener和MiquelRuiz,共同打造了Tiberi酒吧。这是该俱乐部的第一家实体店,并已于2023年初夏开业。Tiber酒吧位于充满活力的PobleSec街区的一个转角处,面积82m^(2)。这个地区以多元的文化特色为亮点,吸引着众多的年轻人。设计师将这个空间打造成一个“宾至如归的酒吧”,完美诠释了Tiberi俱乐部的本质:试图通过提供独特的餐饮体验,来促进陌生人之间的交流和联系。