摘要：AIM：To determine the agreement and repeatability of the pupil measurement obtained with VIP-200（Neuroptics）,Power Ref II（Plusoptix）,WAM-5500（Grand Seiko） and study the effects of instrument design on ***：Forty patients were measured twice in low,mid and high *** was analyzed with the within-subject standard deviation（Sw） and paired *** was studied with Bland-Altman plots and repeated measures *** design analysis consisted on measuring pupil size with Power Ref II simulating monocular and binocular conditions as well as with proximity cues and without proximity ***：The mean difference（±standard deviation） between test-retest for low,mid and high mesopic conditions were,respectively：-0.09（±0.16）,-0.05（±0.18） and-0.08（±0.23） mm for Neuroptics,-0.05（±0.17）,-0.12（±0.23） and-0.17（±0.34） mm for WAM-5500,-0.04（±0.27）,-0.13（±0.37） and-0.11（±0.28） mm for Power Ref *** agreement with Neuroptics,the mean difference for low,mid and high mesopic conditions were,respectively：-0.48（±0.35）,-0.83（±0.52） and-0.38（±0.56） mm for WAM-5500,-0.28（±0.56）,-0.70（±0.55） and-0.61（±0.54） mm for Power Ref *** mean difference of binocular minus monocular pupil measurements was：-0.83（±0.87） mm;and with proximity cues minus without proximity cues was：-0.30（±0.77） ***：All the instruments show similar *** all illumination conditions,agreement of Neuroptics with WAM-5500 and Power Ref II is not good enough,which can be partially induced due to their open field design.