摘要：The study carried out here was focused on develop.ng conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling p.lymer. This system ensures the drug release at the alkaline p. region where the drug has got maximum solubility. Further the study was concentrated on comp.ring the imp.ct of gelling agent p.lyvinyl p.rrolidone on drug release. Quality by design tools were considered during formulation develop.ent and the p.lymer concentrations were op.imized adop.ing the statistical tool, design of exp.riments (DoE). The op.imized formulation of p.esent study exhibited desired controlled drug release characteristics in the alkaline p. conditions and at acidic environment the drug dissolution was minimal as intended.