摘要：A power management unit （PMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done.

摘要：Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal *** to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart *** methods are used to induce MI in the swine ***,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental ***,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine *** carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing *** fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked ***,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days *** method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases.

摘要：A multi-bit antifuse-type one-time programmable （OTP） memory is designed, which has a smaller area and a shorter programming time compared with the conventional single-bit antifuse-type OTP memory. While the conventional antifuse-type OTP memory can store a bit per cell, a proposed OTP memory can store two consecutive bits per cell through a data compression technique. The 1 kbit OTP memory designed with Magnachip 0.18 μm CMOS （complementary metal-oxide semiconductor） process is 34% smaller than the conventional single-bit antifuse-type OTP memory since the sizes of cell array and row decoder are reduced. And the programming time of the proposed OTP memory is nearly 50% smaller than that of the conventional counterpart since two consecutive bytes can be compressed and programmed into eight OTP cells at once. The layout area is 214 μm× 327 μ,, and the read current is simulated to be 30.4 μA.

摘要：Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients,and these shortages are especially devastating in developing *** help alleviate this strain,we have designed and tested the accessible low-barrier in vivo-validated economical ventilator(ALIVE Vent),a COVID-19-inspired,cost-effective,open-source,in vivo-validated solution made from commercially available *** ALIVE Vent operates using compressed oxygen and air to drive inspiration,while two solenoid valves ensure one-way flow and precise cycle *** device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large *** functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator *** large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation *** FiO2,respiratory rate,inspiratory to expiratory time ratio,positive-end expiratory pressure,and peak inspiratory pressure were successfully maintained within normal,clinically validated ranges,and the animals were recovered without any *** regions with limited access to ventilators,the ALIVE Vent can help alleviate shortages,and we have ensured that all used materials are publicly *** this pandemic has elucidated enormous global inequalities in healthcare,innovative,cost-effective solutions aimed at reducing socio-economic barriers,such as the ALIVE Vent,can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.

摘要：本文介绍一种设计具有转差元件和行星齿轮的开环变速箱的车辆的性能预测方法。同时采用数学模型对这种装置的内功率流程图进行理论分析。推荐一种用性能迹线图表示整个装置特性的几何方法有效测定新设计的动力变速箱。它完全可以定性预测性能和设计因素的影响。这些因素是装置的设计 ,行星齿轮传动的类型和速比以及转差元件的设计参数 ,采用测功仪对动力变速器的预测结果进行试验比较。

摘要：一、引言从以往发生的强烈地震,如1968年TokaChi-Oki地震和1971年加利福尼亚的San Fernando地震,得到的经验表明:遭受强地震动的钢筋混凝土建筑物是易于损坏的。然而,由于经济的原因,在结构抗震设计,特别是低层建筑物的抗震设计中,应当预计到允许有某种程度的破坏。尽管有这样的认识,但结构的潜在的地震破坏和有关的地震设防很大程度上还需依靠定性的工程判断。

摘要：背景:利用胸部放射学检查和痰涂片检查手段对中学生进行肺结核病例筛检。目的:调查中学生中结核分枝杆菌的传播情况。设计:对从中学生肺结核病例分离出的结核分枝杆菌进行限制性酶切片段长度多态性(RFLP)图谱分析。结果:筛检发现的中学生病例存在簇状分布现象。在本研究中,一株具有独特RFLP图谱的结核杆菌分离频率最高。该菌株在1995年全国结核病患病率调查中也是最常见的临床分离结核分枝杆菌。该菌株似乎是韩国分布最广的结核杆菌株,编号为K1。经过对RFLP图谱的仔细研究,发现有34株临床分离菌株的RFLP图谱与K1株相似。因此,K1株和K1相关株(占总菌株的18.4％,命名为K系)似构成韩国目前的优势结核分枝杆菌株。结论:筛检发现的中学生病例存在簇状分布现象。K系结核杆菌是临床分离菌株中的最常见型别。

摘要：背景:实时定量PCR技术在微生物包括分枝杆菌检测领域应用越来越广泛。目的:评价在痰标本涂片抗酸染色无法获得诊断信息时(如没有痰或痰涂片阴性),RT-PCR在结核病诊断中的作用。设计:我们分析了从2006年1月至2008年4月之间连续纳入的为诊断结核病而进行的支气管分泌物RT-PCR检测的病人。所有病人均接收了计算机断层扫描(CT)、支气管镜和组织活检确诊结核病,对收集的支气管分泌物进行了微生物学和RT-PCR检测。最终的确诊基于微生物学或临床病理学的标准。结果:有136例患者最终得到了诊断结果,其中77例(包括65例培养阳性病例)诊断为结核。RT-PCR在确诊病人中的阳性率是51.9%(40/77)。与支气管分泌物抗酸染色相比,更多的病人(20.8%)通过RT-PCR被检测出来(40比20,P<0.001)。结合支气管分泌物抗酸染色和RT-PCR,77例结核确诊病例中的44例(57.1%)在几天之内被确诊。结论:支气管分泌物的RT-PCR检测在涂阴或无痰结核病人的快速诊断中是一种有用的方法。

摘要：地点:实施国家结核病控制规划的韩国245个卫生中心及韩国国家结核病协会的结核实验室网络。目的:观察韩国1994-2004年间抗结核药物的耐药趋势和可能的相关因素。设计:评估在给定的时期内,在卫生中心登记治疗的所有结核病人。结果:2004年监测发现的2 636名新涂阳病人中,338例(12.8%,95%可信区间[CI]11.5-14.1)显示对任一一种一线抗结核药物耐药:261例耐异烟肼(INh) (9.9%,95%CI8.8-11.0)。71例为耐多药(MDR)(2.7%,95%CI2.1-3.3)。与先前的监测相比,自1994年以来,新病例中耐药有统计学显著增高的有MDR(P=0.006 75)、任一药物耐药(P=0.03779)、INh耐药(P=0.00313)、利福平耐药(P=0.001 76)。新病例中,对任意一个二线药物耐药介于0.1%(卷曲霉素)和1.1%(对氨基水杨酸)之间,复治病例中,对任意一个二线药物耐药介于1.1%至3.6%之间。新病例和复治病例中,对卡那霉素和氧氟沙星的耐药率分别为1.4%和2.6%。结论:新病例中耐药具有统计学显著增加。

摘要：此研究的目的是设计一个全景腔内显示技术．以影像变形极少的带状显示，明确其作为CT结肠成像（CTC）节省时间的主要三维显示方法的可行性。对照带状显示与其他4种三维显示方法显示10个10mm、10个20mm电子生成息肉影像的变形。52例病人行CTC检查．并于同天行结肠镜检查。对照2名独立读片医生利用带状显示与常规腔内显示的诊断操作与影像诊断时间。