摘要：采用泊洛沙姆407和羟丙甲纤维素（HPMC）K4M为基质，依据质量源于设计（QbD）理论制备载地塞米松磷酸钠（DSP）和硫酸妥布霉素（TS）的热敏性眼用即型凝胶，以期达到延长角膜前滞留时间、提高眼部生物利用度和减少给药频次的目的。

摘要：Various recent reports on Tuberculosis have alarmed an increase in the patient class and subsequent death rates across the globe. Over and above the spread of more dangerous and fatal forms of tuberculosis like MDR-TB i.e. multiple-drug resistance tuberculosis, XDR-TB i.e. extensively-drug resistance tuberculosis & TDR-TB i.e. total-drug resistance tuberculosis has forwarded an urgent need to discover novel antitubercular agents. The current work is aimed at combining two previously well-known pharmacophores (pyrazoline and benzoxazole nucleus) in order to design and synthesize a series of novel benzoxazole-based pyrazoline derivatives. The synthesized target compounds were structurally confirmed by LCMS, 1H-nMR and 13C-nMR analysis. The target compounds were In vitro evaluated against M. tuberculosis H37Rv strain, multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains. The In vitro screening results depicted that majority of the target compounds displayed potent activity with MIC in a range of ~0.8 to 6.25 μg/mL. Many compounds were found to be more potent than isoniazid against MDR-TB with MIC value 3.12 μg/mL and XDR-TB with MIC value 12.5 μg/mL. Cytotoxicity assay of these active compounds on VERO cell lines also displayed good selectivity index.

摘要：目的肿瘤外科医师对手术技术的改进，使乳腺癌切除术后残留的乳房形态得到改善。以背阔肌皮瓣行乳房再造术效果肯定。本研究将评估不同类型的用于乳房再造术的背阔肌皮瓣的皮岛设计，寻找一种广泛用于修复各种乳腺癌切除术后缺损的背阔肌皮瓣设计算法设计原则。方法本研究回顾性分析自2001年2月至2005年4月收治的单侧或双侧乳腺癌切除术后背阔肌皮瓣乳房再造患者的临床资料。在掌握如下情况的前提下进行再造手术：①术前组织是否经放疗处理；②体质量指数是否〉30；③当前有无吸烟习惯；④之前是否做过腹腔骨盆手术；⑤患者的要求。并对患者依据缺损形式进行分组：①乳房下皱襞完整但皮肤量不足；②乳房下皱襞完整且皮肤量足够；③乳房下皱襞缺损伴或不伴皮肤量不足。根据缺损的不同。设计不同的皮岛来优化手术效果，并减少供区瘢痕形成。结果本组患者54例，共应用64块背阔肌皮瓣行乳房再造术。各组间术后外观美学效果及供区瘢痕形成情况不同。结论本研究制定了一种背阔肌皮瓣乳房再造术的相关算法设计模式。通过对乳腺癌切除术后缺损的准确评价，在利用背阔肌皮瓣进行乳房再造术时，可定向切取皮岛，减少供区瘢痕形成，提高美学效果，获得疗效持久、外观自然、美观的乳房。