摘要：The chemical industry is nowadays predominantly using fossil raw materials,but the alternative use of bio-based resources is investigated to account for the foreseeable scarcity of fossil feedstocks.A main challenge of using biobased feedstocks is the complexity of the impurity *** an economic production of bio-based chemicals,the use of intensified processes is inevitable and approaches are needed for the various process intensification techniques to identify their applicability to be used for the production of bio-based *** the presented study,an approach is shown for the reactive distillation(RD) technology to identify the most critical bio-based impurities and their impact on the reactive distillation *** investigated case-study is the production of n-butyl acrylate from acrylic acid and *** all initially identified impurities,the key impurities,having the biggest impact on the product purity in the reactive distillation process,are *** impurities are then studied in more detail and an operating window depending on the impurity concentration is identified for the reactive distillation ***,an integrated design of upstream and downstream processes is facilitated,as the presented results can be used in the development of the fermentation processes for the production of the bio-based reactants by decreasing the concentration of the critical impurities.