摘要：AIM:To assess the symptomatic efficacy of Lactobacillus plantarum 299v(*** 299v)(DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome(IBS) patients fulfilling the Rome Ⅲ ***:In this double blind,placebo-controlled,parallel-designed study,subjects were randomized to daily receive either one capsule of *** 299v(DSM 9843) or placebo for 4 *** and intensity of abdominal pain,bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was ***:Two hundred and fourteen IBS patients were *** 4 wk,both pain severity(0.68 + 0.53 vs 0.92 + 0.57,P < 0.05) and daily frequency(1.01 + 0.77 vs 1.71 + 0.93,P < 0.05) were lower with *** 299v(DSM 9843) than with *** results were obtained for *** week 4,78.1 % of the patients scored the *** 299v(DSM 9843) symptomatic effect as excellent or good vs only 8.1 % for placebo(P < 0.01).CONCLUSION:A 4-wk treatment with *** 299v(DSM 9843) provided effective symptom relief,particularly of abdominal pain and bloating,in IBS patients fulfilling the Rome Ⅲ criteria.