摘要：滚动轴承作为一种精密的机械元件,已广泛运用于现代工业机械设备中。在轴承运行时,采用合理的方法诊断轴承的故障具有重大的意义。但在实际复杂多变环境下,采集振动信号不仅面临样本量少的问题,还受到噪声干扰、工况变换等因素的影响,导致故障诊断的准确率低。因此,针对噪声干扰和变工况下的小样本滚动轴承故障诊断问题,该文提出了一种基于原型域增强的元学习去噪模型(Meta-DAE)。首先,构造基于时频图的小样本故障样本集,引入深度卷积生成对抗网络并对数据进行预处理,生成相似分布的伪样本集;然后,将故障样本集输入Meta-DAE模型进行自适应特征提取,Meta-DAE模型采用原型域增强策略,使同类别原型点在嵌入空间中凝聚更紧密;同时,构建了具有降噪性能的编码器,设计了基于原型域增强和去噪的目标函数,通过在小样本下进行模型微调,以提高小样本下模型的噪声鲁棒性和分类准确率。噪声及变工况下小样本故障诊断实验结果表明,相比于其他模型,所提模型在-8dB强噪声干扰下,仅用10个样本微调模型,分类准确率提高了35.78~57.25个百分点,具有较强的噪声鲁棒性。

摘要：Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with doxorubicin hydrochloride(DOX)loading were *** as photothermal agents were synthesized by a hydrothermal *** was adsorbed on the surface of CNSs,which improved the photothermal conversion efficiency due to the electron transitions between C-2 p and Cu-3 *** addition,CuO would release Cu2+ions in the tumor microenvironment,which could produce hydroxyl radical(·OH)to induce cancer cells apoptosis via Haber-Weiss and Fenton-like *** as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer *** CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy(PTT),chemodynamic therapy(CDT),and chemotherapy(CT),which have strong potential for cancer treatment.

摘要：The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent *** this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was *** porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell *** with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug *** smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 *** release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light *** integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in *** results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.

摘要：A composited integrated guidance and control(IGC) algorithm is presented to tackle the problem of the IGC design in the dive phase for the bank-to-turn(BTT) vehicle with the inaccuracy information of the line-of-sight(LOS) rate. For the sake of theoretical derivation, an IGC model in the pitch plane is established. The high-order finite-time state observer(FTSO), with the LOS angle as the single input, is employed to reconstruct the states of the system online. Besides, a composited IGC algorithm is presented via the fusion of back-stepping and dynamic inverse. Compared with the traditional IGC algorithm, the proposed composited IGC method can attenuate effectively the design conservation of the flight control system, while the LOS rate is mixed with noise. Extensive experiments have been performed to demonstrate that the proposed approach is globally finite-time stable and strongly robust against parameter uncertainty.

摘要：Summary of main observation and conclusion To combat multidrug-resistant Gram-positive bacteria,new antimicrobials particularly those with novel mechanism of action are badly *** with conventional antibiotics which are typical inhibitors,small-molecule activators of bacterial CIpP represent a new class of *** ClpP activator has been developed for clinical ***,we conducted a screening on our library of benga-mide-like ring opened analogues and found that L472-2 possesses a low minimum inhibitory concentration(MIC)against *** and shows no activity for ClpP activation in vitro,but it displayed reduced antibacterial activity against *** with clpP *** order to obtain bengamide analogues that activate ClpP in vitro as well as possess antibacterial activity,we perform further structural modifications starting from *** 37 re-mains the antimicrobial activity and activation of ClpP protein in vitro,which could be viewed as a new chemical scaffold for ClpP activators and worthy of further investigation.

摘要：传统的审美理想是希腊人信奉的理想美,这种美是永恒的,无始无终,不生不灭,不增不添的,它只是永恒地自存自在,以形式的整一永与它自身同一;随着社会的不断演进,科学技术的不断发展,信仰不再唯一,人们开始怀疑上帝的真实存在,怀疑一切形而上学的人类"先验幻象",宗教之知识论的毁灭导致伦理观的崩溃,导致其禁欲功能的破坏。艺术开始从神坛走向生活,表现生活中的一切现象包括被传统审美认为是丑的而不被表现的事物和思想情感;而当代艺术极力否定传统绘画,试图打破艺术与生活的界限,将艺术从原有的画布和雕塑的基座上搬到人们的生活中,延伸到世界的每一个角落,极大的消解了现代艺术那种清教徒式的贵族面孔,转而呈现一种超越边界的无限开放的姿态。二者的相互转换使得艺术与生活融合起来。弥补了艺术与现实、艺术与非艺术、艺术与大众之间的鸿沟,最终达到超越现代艺术的目的。

摘要：目的 提高产品宣传册版面设计的审美功能,强化设计主题,刺激消费者,激发消费者的阅读欲望.方法 以产品宣传册版面设计中文字造型化的应用为研究点,挖掘出文字形体造型化、文字排列造型化和图文排列造型化三种方式,使文字的视觉传达效果得到充分的发挥.结论 在"读图时代"的今天,设计师都不同程度地忽视文字的设计与编排,将设计重点放在图片与色彩上,造成文字编排方式的千篇一律,使读者丧失阅读兴趣,不利于读者对信息的吸收和交流.文字作为版面设计中不可或缺的元素,不仅担负着供读者阅读的基本功能,而且承担着塑造版面视觉审美风格、强化设计主题的艺术功能.由此可见,完善文字的信息传达效果,促使文字能够发挥出像图形一样的影响力,至关重要.

摘要：当代艺术全球化语境下战争叙事的表达格外具有优势,它所具备的互动性、普适性、多元性、当代性和自我意识等本质特性都契合了后战争时代具有世界主义内涵的战争创伤记忆的叙事和表征。很多战争题材的博物馆都利用当代艺术展品去实现心灵抚慰和促进战争反思,以此丰富战争历史当代表达,拓展和平教育职能。当代艺术所具备的抽象性特质使其在介入体现普适性价值、为战争博物馆实现心灵抚慰记忆的目标提供了有效路径。当代艺术是推动战争题材博物馆从"仪式性空间"向"反思性空间"转型过程中不可替代的一种新方法。

摘要：国内文化创意产业迅速发展,产品中潜移默化的文化创意可以让人们的精神文化需求得到满足,这也逐渐成为了消费决策的核心要素。设计类专业的培养要紧贴社会的需要,在“文化创意产品设计”课程中融入地域元素的方式可以使产品注入更多的文化内涵。目前“文化创意产品设计”课程存在一些问题,为了使课程能够更好地提升学生的综合设计能力,文章针对学情调整教学内容,根据教学目标完成教学设计,依据学生的实际情况提升学生的设计整合能力。以期培养出具有综合能力的应用型设计人才。