摘要：目的探讨一种预防和治疗肱骨髁上骨折以及并发肘内翻的临床疗效。方法将纳入患者分为肱骨髁上骨折组(A组)及骨折后肘内翻畸形组(B组),采用自行设计的双克氏针交叉外翻张力固定方法治疗。术后随访并评价疗效。结果术后骨折及截骨均愈合良好,肘关节功能恢复满意,A组肘内翻12例,发生率为3.9%,总优良率为88.9%;B组肘内翻复发2例,复发率为3.2%,总优良率为94%。结论克氏针交叉外翻张力固定是预防和治疗小儿肱骨髁上骨折后肘内翻的良好固定方法。

摘要：目的评价2种替硝唑片在中国健康受试者中的生物等效性及安全性。方法按单中心、随机、开放、单次给药、两序列、两制剂、两周期、交叉试验研究设计方法,在餐后条件下,共入组24例健康受试者,随机交叉单次口服受试制剂和参比制剂各500 mg,用HPLC-MS/MS法来测定受试者血浆中替硝唑浓度,用Phoenix WinNonlin(7.0版本)软件以计算替硝唑药代动力学参数,并进行生物等效性评价。结果受试者在服用受试制剂和参比制剂后,其血浆中替硝唑主要药代动力学参数如下:Cmax分别为(1.21×10^4±2048.85)和(1.20×10^4±2132.68) ng·mL^-1;AUC0-t分别为(24.93×10^4±3.62×10^4)和(24.55×10^4±3.06×10^4) ng·h·mL^-1;AUC0-∞分别为(25.96×10^4±3.91×10^4)和(25.60×10^4±3.27×10^4) ng·h·mL^-1。2种制剂的Cmax、AUC0-t和AUC0-∞经对数转换后的90%可信区间为96.11%~106.45%,99.41%~103.12%,99.25%~103.02%。结论 2种替硝唑片在中国健康受试者中具有生物等效性。

摘要：An old drug with a new use can significantly reduce the cost and time for new drug research and development. MAPK (Mitogen-activated protein kinase) plays a very important key role in signal transduction pathways of cell proliferation and differentiation. According to the statistics, there are about 30% persons who suffered from cancers related to the MAPK signal transduction pathways. Therefore, many researchers are focused on blocking these pathways in cancers therapies. Ras/Raf/MEK/ERK, however, is one of very important pathways among MAPK message transduction pathways. More and more information about MEK protein inhibitors are unveiled in several recent years. In the present study, the authors utilized MEK inhibitors which were already published and their activities were available to construct 2D-QSAR model by using CADD (multiple linear regression). Then, the authors searched certified FDA drugs (Drugs@FDA 6184 drugs) making preliminary screening. The secondary screening on 3D structures were followed by using Docking, Scoring and Pharmacophore analysis to find out most suitable MEK inhibitors to become a fundamental database in drug discovery. The results are shown the ALogP, number of aromatic rings, number of hydrogen bond acceptors and number of hydrogen bond donors are all in positive correlation. According to the equation from 2D-QSAR model, the results conform to the previous description.

摘要：The mitogen-activated protein kinase (MAPK) cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 (MEK1) in MAPK, and use computer aided drug design (CADD) to analyze the ligand activities of proteins in MEK1. The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

摘要：目的:探讨类风湿关节炎(RA)发病与季节和地域因素的相关性,为RA防治提供证据支持。方法:设计RA病证规律调查表,对华北、东北、华东、西南、西北、中南6个地区18家研究中心收集的1 602例RA患者进行横断面调查分析。结果:RA发病以春季最为多见,占36.33%,其次为冬季和夏季,分别占26.22%和25.53%。秋季发病最少,占11.92%,各季节发病率具有显著差异(P<0.01)。除西南地区外,全国其他各地区,均以春季发病最为常见,春、夏、冬季发病率在各地区间具有显著性差异(P<0.05),西南地区RA以冬季高发,全国所调查地区均以秋季发病最少。结论:RA的发病具有明显的季节性和地域性差异。